Chemotactic Factors

Chemical substances that attract or repel cells. The concept denotes especially those factors released as a result of tissue injury, microbial invasion, or immunologic activity, that attract LEUKOCYTES; MACROPHAGES; or other cells to the site of infection or insult.

Also Known As:

Networked: 977 relevant articles (5 outcomes, 65 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wang, Ji Ming: 7 articles (06/2013 - 01/2002)
2.	Luster, Andrew D: 5 articles (02/2012 - 04/2006)
3.	Le, Yingying: 5 articles (02/2010 - 01/2002)
4.	Strieter, Robert M: 5 articles (11/2005 - 04/2002)
5.	Xue, Ying Ying: 4 articles (11/2005 - 07/2002)
6.	Keane, Michael P: 4 articles (11/2005 - 07/2002)
7.	Burdick, Marie D: 4 articles (11/2005 - 07/2002)
8.	Belperio, John A: 4 articles (11/2005 - 07/2002)
9.	Herwald, Heiko: 3 articles (12/2015 - 12/2008)
10.	Kovacs, Elizabeth J: 3 articles (11/2015 - 04/2011)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2015 - "By identifying specific chemoattractants and inhibitors, this modified invasion assay may help to elucidate signaling pathways that direct cancer cell invasion. " 01/01/2010 - "In accordance with our previous in vitro experiments, this study demonstrates for the first time that IFI16 exerts in vivo anti-tumoral activity by promoting apoptosis of tumor cells, by inhibiting neo-vascularisation, and by increasing the recruitment of macrophages through the release of chemotactic factors." 10/01/2000 - "In this study, we report that needles containing chemoattractants can be used to collect the subpopulation of motile and chemotactic tumor cells from a primary tumor in a live rat as a pure population suitable for further analysis. " 06/01/2015 - "Tumor-homing eosinophils secreted chemoattractants that guided T cells into the tumor, which resulted in tumor eradication and survival. " 06/01/2015 - "Pseudopodia are ventral membrane protrusions that extend toward higher concentrations of chemoattractants and play key roles in cell migration and cancer cell invasion. "
2.	Inflammation 04/01/2014 - "Using an established murine model of intratracheal NE-induced airway inflammation, we tested the efficacy of intratracheal ODSH to block NE-generated neutrophil chemoattractants and NE-triggered airway neutrophilic inflammation. " 09/30/2011 - "Accordingly, these studies demonstrate the therapeutic potential of targeting this shared receptor to simultaneously alleviate neutrophilic inflammation driven by multiple neutrophil chemoattractants." 09/01/2000 - "Although recent studies have highlighted the role of particular chemoattractants in leukocyte migration, to date little is known about how specific combinations of contextual signals control the migration of leukocytes and their localization at sites of inflammation. " 10/01/1998 - "This study investigated whether these cells also promote hepatic inflammation by producing neutrophil chemoattractants. " 06/01/1998 - "The evidence supporting the role of chemotactic factors in renal inflammation comes from three types of studies. "
3.	Infection 09/01/1996 - "The regulation of polymorphonuclear leukocyte chemoattractants in the brain parenchyma during injury and infection is an important area for future studies." 01/01/1987 - "Previous studies indicate that endogenous chemotaxins, such as the chemotactic factor C5a, may modulate the function of neutrophils (PMNs) and account for increased susceptibility to infection after injury. " 12/01/2015 - "The increased susceptibility of TLR9(-/-) mice was due to the impaired recruitment of neutrophils to the infection foci associated with reduced levels of neutrophil chemoattractants released by DCs in the target organs. " 05/01/2015 - "In vitro infection of lung-derived cell-lines with a YopJ mutant revealed the involvement of YopJ in the inhibition of chemoattractants expression. " 01/01/2015 - "It is based mainly on the ability to secrete chemotactic factors allowing the accumulation of professional immunocompetent cells at the site of infection, thus enhancing the effective eradication of an infectious agent. "
4.	Wounds and Injuries (Trauma) 01/01/2001 - "Previous studies suggest that normal wound repair requires the regulated production of monocyte and macrophage chemoattractants. " 02/01/2015 - "Fractures may decrease lung bacterial clearance because FP suppresses PMN CTX to other chemoattractants via FPR-1/2. Trauma activates NETosis but suppresses maximal NETosis. " 04/06/2014 - "This model takes into account the diffusion of chemoattractants both in the wound and the neighbouring tissue, the uptake of these molecules by the surface receptors of epithelial cells, the migration of the neighbour epithelium, the tension and proliferation at the wound border. " 01/01/2008 - "In chronic wounds, fibroblasts show a senescence-like phenotype with decreased secretion of neutrophil chemoattractants that make it more likely that biofilms become established. " 09/01/1983 - "Both serum and wound fluid contained chemoattractants for fibroblasts and endothelial cells. "
5.	Fibrosis (Cirrhosis) 11/01/2002 - "These results suggested that Mg supplementation abolished CsA-induced precedent inflammatory cell influx possibly via inhibition of expression of chemoattractants and consequently suppressed tubulointerstitial fibrosis. " 12/01/1996 - "Expression of leucocyte chemoattractants by interstitial renal fibroblasts: up-regulation by drugs associated with interstitial fibrosis." 01/01/1993 - "The influx of monocytes observed during the early stages of fibrosis is at least partially regulated by the elaboration of chemotactic factors in the lung. " 09/27/2002 - "Mg supplementation abolished CsA-induced precedent interstitial inflammation possibly via inhibition of chemoattractants expression and consequently attenuated tubulointerstitial fibrosis. " 07/01/2001 - "Because eosinophils are believed to be involved in wound healing, tissue remodeling, and fibrosis, their presence within LMs may reflect a response to tissue injury produced by the neoplasm rather than intrinsic recruitment by chemotactic factors produced by the smooth muscle cells. "

Related Drugs and Biologics

1.	Bleomycin (Blenoxane)
2.	Biological Markers (Surrogate Marker)
3.	Messenger RNA (mRNA)
4.	Cytokines
5.	Interleukins
6.	Leukotriene B4
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
8.	Chemokine CCL5
9.	N-Formylmethionine Leucyl-Phenylalanine
10.	Interleukin-8 (Interleukin 8)

Related Therapies and Procedures

1.	Immunotherapy
2.	Renal Dialysis (Hemodialysis)
3.	Intravenous Infusions
4.	Homologous Transplantation (Allograft)
5.	Intraperitoneal Injections