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Uterine Cervical Neoplasms (Cancer of the Cervix)

Subscribe to New Research on Uterine Cervical Neoplasms

Tumors or cancer of the UTERINE CERVIX.

Also Known As:

Cancer of the Cervix; Cervical Cancer, Uterine; Cervical Neoplasm; Cancer of Cervix; Cancer of the Uterine Cervix; Cervical Neoplasms; Cervix Cancer; Cervix Neoplasms; Neoplasms, Cervical; Neoplasms, Cervix; Uterine Cervical Cancer; Cancer, Cervix; Cancer, Uterine Cervical; Cancers, Cervix; Cancers, Uterine Cervical; Cervical Cancers, Uterine; Cervical Neoplasm, Uterine; Cervical Neoplasms, Uterine; Cervix Neoplasm; Neoplasm, Cervical; Neoplasm, Cervix; Neoplasm, Uterine Cervical; Neoplasms, Uterine Cervical; Uterine Cervical Cancers; Uterine Cervical Neoplasm

Networked: 2047 relevant articles (72 outcomes, 288 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Lung Neoplasms (Lung Cancer)
3.	Ovarian Neoplasms (Ovarian Cancer)
4.	Uterine Cervical Neoplasms (Cancer of the Cervix)
5.	Neoplasm Metastasis (Metastasis)

Experts

1.	Pötter, Richard: 28 articles (06/2015 - 11/2002)
2.	Kirisits, Christian: 25 articles (06/2015 - 03/2005)
3.	Toita, Takafumi: 18 articles (10/2015 - 04/2002)
4.	Ohno, Tatsuya: 13 articles (09/2015 - 12/2005)
5.	Berger, Daniel: 12 articles (06/2015 - 04/2006)
6.	Milosevic, Michael: 12 articles (02/2014 - 07/2002)
7.	Lang, Stefan: 12 articles (04/2013 - 03/2005)
8.	Nakano, Takashi: 11 articles (09/2015 - 12/2005)
9.	Kim, Joo-Young: 11 articles (03/2014 - 02/2004)
10.	Fyles, Anthony: 11 articles (02/2014 - 03/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Uterine Cervical Neoplasms:

1.	Cisplatin (Platino)FDA LinkGeneric 01/01/1997 - "CIFX improved the response rate and PFS duration in advanced cervix cancer compared with cisplatin alone, but at the cost of greater toxicity and with no improvement in survival." 10/01/2013 - "Daily low-dose cisplatin-based concurrent chemoradiotherapy in patients with uterine cervical cancer with emphasis on elderly patients: a phase 2 trial." 08/01/2006 - "Feasibility of concurrent cisplatin use during primary and adjuvant chemoradiation therapy: a phase I study in Japanese patients with cancer of the uterine cervix." 07/01/2014 - "Cisplatin-based concurrent chemoradiotherapy (CCRT) has become a standard treatment for cancer of the uterine cervix. " 01/01/2014 - "For this reason, we aimed to understand the role of Bag-1 expression in Cisplatin- induced apoptosis in HeLa cervix cancer cells. "
2.	PlatinumIBA 12/01/2012 - "Metastatic and recurrent, platinum resistant cervix cancer has an extremely poor prognosis. " 05/01/2010 - "The in vitro cytotoxic analyses for the platinum complex using HeLa (human cervix cancer) cells show its low activity when compared to the vehicle-treated cells. " 01/01/2006 - "Simultaneous platinum-based radiochemotherapy is the standard of care for patients with advanced or node-positive cancer of the uterine cervix. " 09/01/1985 - "Potential for platinum analogs in the treatment of cancer of the uterine cervix." 01/01/2000 - "The purpose of this study was to explore the effect of concurrent intra-arterial infusion of platinum drugs in patients with stage III or IV uterine cervical cancer treated with radical radiation therapy. "
3.	gemcitabine FDA Link 11/01/2005 - "Concurrent gemcitabine radiotherapy provided a satisfactory response in patients with uterine cervical cancer with mild toxicity. " 11/01/2005 - "A retrospective review of medical records of 41 patients with uterine cervical cancer patients, stage IIB and above treated with concurrent gemcitabine radiotherapy from August 2000 to August 2003. " 11/01/2005 - "To determine response, complication and survival of uterine cervical cancer patients treated with concurrent gemcitabine radiotherapy. " 11/01/2005 - "Gemcitabine and radiotherapy in the treatment of uterine cervical cancer patients at Phramongkutklao Hospital." 02/01/2003 - "The purpose of this study was to investigate the exact dose dependency and time dependency of the radiation-enhancing effect of gemcitabine (2',2'difluoro desoxycytidine [dFdC]) in in vitro experiments (HeLa cells: cancer of the uterine cervix, #4197 cells: oropharyngeal squamous cell carcinoma), and to correlate this effect with the underlying changes in cell cycle distribution. "
4.	irinotecan (Camptosar)FDA LinkGeneric 12/01/2013 - "The combination of CPT-11 and NDP seems to be active for patients with recurrent uterine cervical cancer." 08/01/1991 - "These results suggest that CPT-11 is clinically effective against uterine cervical cancer and ovarian cancer." 08/01/1991 - "[A late phase II study of CPT-11 on uterine cervical cancer and ovarian cancer. " 04/01/1994 - "Recent clinical trials also reveal that CPT-11 is very effective in the treatment of cancers including lung cancer, cervix cancer, ovary cancer, etc. Now, comparative trials of combination chemotherapy in responsive tumors are indicated from these excellent clinical results." 05/01/2010 - "In cervix cancer patients, radiosensitization with weekly cisplatin and irinotecan is feasible, and the recommended doses are cisplatin 20 mg/m(2)/week and irinotecan 35 mg/m(2)/week for future phase II studies."
5.	Carboplatin (JM8)FDA LinkGeneric 06/01/2003 - "Patients with cervix cancer can be treated on schedule with concurrent carboplatin and pelvic radiation therapy. " 06/01/2003 - "The objectives were to determine the acute toxicities of concurrent carboplatin and radiation therapy in the primary treatment of cervix cancer and to ascertain the antitumor activity of this regimen. " 06/01/2003 - "Concurrent carboplatin with pelvic radiation therapy in the primary treatment of cervix cancer." 05/01/1998 - "Carboplatin is the drug of choice in the treatment of the early recidivations of the cervix cancer." 02/01/1998 - "[Radiotherapy and carboplatin in cervix cancer]."
6.	AK 2123IBA 04/01/2005 - "AK-2123 (Sanazol) as a radiation sensitizer in the treatment of stage III cancer cervix: initial results of an IAEA multicentre randomized trial." 06/01/2002 - "Sanazole as a sensitizer of hypoxic cells with radical radiation in the treatment of advanced cancer of cervix an Indian experience." 01/01/1992 - "Based on a clinical differential effect of the action of a new hypoxic cell radiosensitizer, AK-2123 (a 3-nitro-1,2,4-triazole), on locally advanced cervix cancer (Stage II-B and III-B), a Phase I/II clinical trial has been carried out on 80 consecutive patients. " 01/01/2007 - "A prospectively randomised trial was initiated by the International Atomic Energy Agency (IAEA) evaluating AK-2123 and radiotherapy in treatment of uterine cervical cancer stage III and IV. A total of 462 patients were randomised from 8 centres. " 04/01/2005 - "A prospectively randomised trial was initiated by the International Atomic Energy Agency (IAEA) evaluating AK-2123 and radiotherapy in treatment of uterine cervical cancer stage IIIA and IIIB. "
7.	DNA (Deoxyribonucleic Acid)IBA 05/01/2010 - "The present study was conducted in patients with human papillomavirus 16 DNA-positive uterine cervical cancer to determine the plasma level of human papillomavirus 16 DNA and the diagnostic values of plasma human papillomavirus DNA in these patients. " 09/01/1992 - "[The study of DNA ploidy as a prognostic factor in uterine cervical cancer]." 01/01/1991 - "The aim of this study was to investigate papillomavirus (HPV)-DNA in precancer and cancer of the cervix, vulva, and endometrium by in situ/dot blot/Southern blot hybridization and polymerase chain reaction (PCR). " 03/01/2014 - "As identical human papillomavirus (HPV)-16 DNA was detected in both the EBM and in previously resected tissues from the prior uterine cervical cancer, the patient was diagnosed with EBM from uterine cervical cancer. " 04/01/2013 - "All women simultaneously underwent cervical cytology, HPV DNA test and cervicography for uterine cervical cancer screening and colposcopically directed biopsy for diagnostic evaluation. "
8.	Fluorouracil (Carac)FDA LinkGeneric 07/01/1987 - "A phase II study of 5-FU tablet for 52 patients with cancer of the uterine cervix was undertaken by a cooperative study group consisting of 13 institutions. " 08/01/1988 - "As one method of multidisciplinary treatment for cancer of the uterine cervix, a combination IAC using CDDP and 5-FU was applied. " 12/01/1992 - "Twenty four patients with advanced cancer of cervix were submitted to sequential chemotherapy 5FU and MTX. " 05/20/1990 - "A total of 10 uterine cervical cancer patients (stage IIb 2, stage IIIb 6, stage IVb 2) were treated two times with selective intra-arterial injection of combined drugs of CDDP, ADR, 5-FU, MMC before operation or radiation therapy. " 11/01/1985 - "[Level of 5-FU in uterine cervical cancer tissue after oral administration of UFT]."
9.	Paclitaxel (Taxol)FDA LinkGeneric 05/01/2009 - "Paclitaxel remains in human uterine cervical cancer tissues for 6 days. " 03/01/2001 - "In view of the known activity of the two agents in several malignancies, including cervix cancer, it would be reasonable to investigate the delivery of the agents employing alternative treatment schedules predicted to result in less severe marrow suppression (e.g., 3-h infusional paclitaxel)." 03/01/1996 - "Paclitaxel has moderate activity in squamous cervix cancer. " 03/01/1996 - "As limited drug supplies became more plentiful, a phase II trial of Taxol was initiated in patients with advanced squamous cervix cancer who had received no prior chemotherapy. " 12/01/2013 - "Cervix cancer is the second most common cancer among women worldwide, whereas paclitaxel, the first line chemotherapeutic drug used to treat cervical cancer, shows low chemosensitivity on the advanced cervical cancer cell line. "
10.	Ifosfamide FDA LinkGeneric 01/01/1990 - "Phase II studies of ifosfamide alone and in combination in cancer of the cervix." 09/01/1991 - "Ifosfamide is an active chemotherapeutic agent in a wide range of gynecologic tumors; favorable response rates have been reported in ovarian (epithelial and germ cell), uterine, and cervical neoplasms. " 01/01/1990 - "This study was carried out to assess the efficacy of high-dose ifosfamide/mesna (HDIFM) in the treatment of advanced or recurrent cancer of the cervix. " 01/01/1990 - "Ifosfamide and mesna at high doses for the treatment of cancer of the cervix: a GETLAC study." 12/01/1993 - "Bleomycin, cisplatinum and ifosfamide infusion chemotherapy in advanced/recurrent cancer of cervix."

Therapies and Procedures

1.	Radiotherapy 02/01/1989 - "These results suggest that the radiotherapy with administration of UFT was more effective against uterine cervical cancer than radiation alone and it is important to administer UFT orally after radiation as well as before radiation." 02/01/1973 - "With improved radiotherapy techniques, the number of patients with isolated central failure is steadily diminishing, but there remains a significant number of patients with recurrent cancer of the cervix after radiation therapy for whom the procedure offers the only chance for life. " 01/01/2005 - "Radiotherapy is effective in treating cancer of the cervix. " 04/01/2001 - "Between 1989 and 1994, a prospective clinical trial tested the safety and efficacy of concomitant boost accelerated superfractionated (CBASF) radiotherapy for patients with locally advanced cervix cancer. " 01/01/2000 - "Disease-free patients treated for cancer of the cervix with radiotherapy have psychological reactions. "
2.	Drug Therapy (Chemotherapy) 08/01/1990 - "Systemic chemotherapy has been widely used for the purpose of inducing remission of advanced cancer of the cervix. " 02/01/1990 - "These results suggested that intra-arterial chemotherapy (CDDP 100mg and PEP 40 mg in a dose) was effective for advanced cancer of the cervix and that renal disorders including tubular and glomerular impairment, which are the adverse effects of the therapy, were mild and reversible." 09/01/2006 - "Several studies have confirmed that neoadjuvant chemotherapy and concurrent chemoradiation improved survival compared with standard therapy for uterine cervical cancer. " 08/01/2015 - "Neoadjuvant chemotherapy followed by surgery is associated with improved survival for women with stage IB2-IIA cervix cancer. " 04/01/1992 - "The unfavorable prognosis for patients with advanced and bulky early stage cancer of the cervix may be improved by initial neoadjuvant cytoreductive chemotherapy. "
3.	Brachytherapy 05/01/1990 - "252Cf neutron brachytherapy was tested in a feasibility trial for efficacy for cervix cancer therapy vs. high stage radioresistant and subsequently for all stages of disease. " 01/01/2011 - "Using a three fraction scheme, high dose rate brachytherapy is safe and effective in the management of cervix cancer." 08/01/2001 - "This series suggests that 45 Gy to the whole pelvis combined with four fractions of 6 Gy to point A with HDR brachytherapy is an effective and safe fractionation schedule in the treatment of Stages II and III cervix cancer if realized up to 50 days. " 12/01/2011 - "Image-guided brachytherapy (IGBT) is the new gold standard for cervix cancer brachytherapy. " 09/01/2012 - "To evaluate and compare the efficacy of medium-dose-rate (MDR) and low-dose-rate (LDR) intracavitary brachytherapy (ICBT) for uterine cervical cancer. "
4.	Hysterectomy 10/01/1980 - "[A discussion on procedure of radical hysterectomy for cancer of cervix uteri and the method of prevention of major complication---recommending an improved technique (author's transl)]." 01/01/1991 - "Treatment of 102 patients with cancer of the cervix by class II and III radical hysterectomy was reviewed to compare the operative morbidity and efficacy of class II radical hysterectomy for select cases. " 01/01/1951 - "Can the results of irradiation in cancer of the uterine cervix be improved by prophylactic hysterectomy?" 06/01/2015 - "PORT after radical hysterectomy in uterine cervical cancer showed excellent OS in this study. " 12/01/2013 - "We believe that this surgery is a plausible alternative to radical abdominal hysterectomy and could be considered to be a valid approach for the treatment of patients with cervical neoplasms, but still randomized trials are needed on this topic with respect to the ethical issues involved."
5.	Combination Drug Therapy (Combination Chemotherapy) 12/01/1997 - "This type of combination chemotherapy seems to be effective for the treatment of locally advanced uterine cervical cancer." 12/01/1985 - "Adjuvant combination chemotherapy in the treatment of advanced cancer of the uterine cervix." 09/01/1985 - "Eight patients with gynecologic cancer (cervix: 6, corpus: 1 and vulva: 1) were treated with combination chemotherapy, PPM therapy consisting of continuously infused PEP 4mg/m2 days 1-5, CDDP 13 mg/m2 days 1-5, and MMC 3mg/m2 day 1. This was repeated every three to five weeks. " 01/01/1981 - "[Morphologic criteria of the effectiveness of intralymphatic polychemotherapy in patients with cancer of the cervix]." 09/01/1991 - "High-dose-rate afterloading brachytherapy, external radiation therapy, and combination chemotherapy in poor-prognosis cancer of the cervix."