Uterine Cervical Incompetence

Incompetent UTERINE CERVIX is usually diagnosed in the second trimester of PREGNANCY. It is characterized by passive painless cervical dilation in the absence of UTERINE CONTRACTION; BLEEDING; INFECTION; and sometimes with the amniotic sac (AMNIOTIC MEMBRANE) bulging through the partially dilated cervix. Left untreated, this condition may lead to premature pregnancy loss, such as HABITUAL ABORTION.

Also Known As:

Networked: 73 relevant articles (1 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Rupture
2.	Premature Obstetric Labor (Premature Labor)
3.	Uterine Hemorrhage (Uterine Bleeding)
4.	Placenta Previa
5.	Hemorrhage

Experts

1.	Butt, Kimberly: 2 articles (02/2018 - 05/2011)
2.	Crane, Joan M: 2 articles (02/2018 - 05/2011)
3.	Lim, Kenneth: 2 articles (02/2018 - 05/2011)
4.	Althuisius, Sietske: 1 article (01/2023)
5.	Berghella, Vincenzo: 1 article (01/2023)
6.	Bornstein, Eran: 1 article (01/2023)
7.	Gulersen, Moti: 1 article (01/2023)
8.	Lenchner, Erez: 1 article (01/2023)
9.	Nicolaides, Kypros H: 1 article (01/2023)
10.	Otsuki, Katsufumi: 1 article (01/2023)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Uterine Cervical Incompetence:

1.	PolyestersIBA 01/01/2000 - "Scanning electron microscopy and X-ray diffraction studies in the analysis of medical materials: Gore-Tex versus braided polyester tape for repair of the incompetent cervix." 11/01/1994 - "Expanded polytetrafluoroethylene patch versus braided polyester tape for the repair of incompetent cervix."
2.	ElastinIBA 11/01/1987 - "There may be a relationship between changes in cross-linked elastin and the incompetent cervix; further studies are therefore indicated."
3.	Diethylstilbestrol (Stilbestrol)FDA Link 05/01/2001 - "We included women who had an unclear history of incompetent cervix as follows: second-trimester loss or termination, > or =3 first-trimester terminations, cone biopsy or loop electrosurgical excision, or exposure to diethylstilbestrol. " 02/01/1979 - "Successful management of incompetent cervix in a primigravida exposed to diethylstilbestrol in utero." 07/01/1978 - "Incompetent cervix in offspring exposed to diethylstilbestrol in utero." 07/01/1996 - "Preterm labor was associated independently with young maternal age, low pre-pregnant weight, low weekly weight gain, nulliparity, previous preterm birth, histories of two or more induced abortions, spontaneous abortions, or stillbirths, uterine exposure to diethylstilbestrol (DES), incompetent cervix, uterine anomaly, and pyelonephritis. "
4.	IsoxsuprineFDA Link 01/01/1969 - "[Isoxsuprine hydrochloride in the incompetent cervix]." 06/01/1966 - "Isoxsuprine hydrochloride (Duvadilan) in pregnancy with incompetent cervix following amputation. "
5.	Hormones (Hormone)IBA 05/01/1978 - "Incompetent cervix in a hormone-exposed offspring." 01/01/2004 - "Treatment of incompetent cervix contains surgical methods ( cerclage and others) and conservative management as follow: tocolytics, hormones, bed rest and mechanical factors (pessary, rings, balloons etc). "
6.	Fibronectins (Fibronectin)IBA 02/01/2018 - "Published literature was retrieved through searches of PubMed and The Cochrane Library up to December 2009, using appropriate controlled vocabulary and key words (preterm labour, ultrasound, cervix, incompetent cervix, transvaginal, transperineal, cervical length, fibronectin). " 05/01/2011 - "Published literature was retrieved through searches of PubMed and The Cochrane Library up to December 2009, using appropriate controlled vocabulary and key words (preterm labour, ultrasound, cervix, incompetent cervix, transvaginal, transperineal, cervical length, fibronectin). "
7.	CollagenIBA 04/01/1988 - "Most likely, these data reflect a high turnover of collagen in incompetent cervices, resulting in a high proportion of newly synthesized collagen with low biomechanical strength." 01/15/1965 - "COLLAGEN-MUSCLE RATIO IN CLINICALLY NORMAL AND CLINICALLY INCOMPETENT CERVICES."
8.	DinoprostIBA 01/01/1988 - "[The use of a double balloon catheter in the topical extra-amniotic administration of prostaglandin F2alpha gel in indicated labor induction and cervix incompetence]."
9.	Tocolytic Agents (Tocolytics)IBA 01/01/2004 - "Treatment of incompetent cervix contains surgical methods ( cerclage and others) and conservative management as follow: tocolytics, hormones, bed rest and mechanical factors (pessary, rings, balloons etc). "
10.	SiliconesIBA 05/15/1972 - "Silicone-plastic cuff for the treatment of the incompetent cervix in pregnancy."

Therapies and Procedures

1.	Cervical Cerclage 02/01/1989 - "Cervical cerclage high enough at the level of the internal ostium is effective in treating incompetent cervix. " 02/01/1987 - "The study clearly demonstrates the beneficial effects of cervical cerclage operations in patients who have suffered from preventable fetal losses because their incompetent cervix was undiagnosed. " 02/01/2012 - "To our knowledge this is the first case of congenital dislocation of the knee reported after cervical cerclage of an incompetent cervix to prevent a pre-term delivery. " 04/01/2008 - "Evaluation of cervical cerclage for sonographically incompetent cervix in at high risk patients." 02/01/2005 - "We conducted a literature review, using the terms "cerclage," "cervical," "emergent or emergency cerclage," "rescue cerclage," and "incompetent cervix," using an OVID interface to access MEDLINE records. "
2.	Pessaries 01/01/2009 - "A variety of studies suggest that pessaries can increase the percentage of full-term deliveries when used in women with an incompetent cervix. " 07/01/2000 - "Because of the poor nature of most of the studies, pessaries should not replace cerclage use at this time in women with an incompetent cervix. " 07/01/2000 - "A variety of studies suggest that pessaries can increase the percentage of full-term deliveries when used in women with an incompetent cervix or at risk for preterm delivery. " 07/01/2000 - "The purpose of this study was to review published articles about using pessaries in women with an incompetent cervix or who are at risk for preterm delivery. " 01/01/2009 - "This article reviews the published literature concerning the use of pessaries in women with an incompetent cervix or at risk of early delivery."
3.	Therapeutics 08/01/1982 - "The results of this study suggest that (1) functional cervical incompetence may play a major role in HA; (2) a widened uterine isthmus at HSG and first trimester cervical effacement are clinical signs that may define this group of HA; (3) early recognition and therapy for the incompetent cervix can interrupt the progression of events leading to the loss of an otherwise normally developing fetus; and (4) increased perinatal morbidity demands continuous antepartum assessment of fetoplacental integrity in these patients." 05/01/1990 - "So therapy of an incompetent cervix should include competent vaginal sanitation. " 08/01/1971 - "[Surgical therapy of the incompetent cervix]." 07/01/2000 - "Bedrest and cervical cerclage has become standard therapy in the United States for women with an incompetent cervix. "
4.	Obstetric Surgical Procedures 01/01/2023 - "Ovid MEDLINE, Scopus, and the Cochrane Central Register of Controlled Trials were searched using the following terms: "cerclage, cervical," "uterine cervical incompetence," "obstetrical surgical procedures," "cervix uteri," "randomized controlled trial," and "controlled clinical trial." All randomized controlled trials comparing cerclage placement with no cerclage in singleton gestations with a transvaginal ultrasound-detected short cervical length ≤25 mm between 24+0/7 and 29+6/7 weeks of gestation were eligible for inclusion. "
5.	Sutures (Suture) 01/01/1999 - "Comparison of delayed absorbable suture v nonabsorbable suture for treatment of incompetent cervix." 11/01/1997 - "However the insertion of a transabdominal cervicoisthmic suture is indicated in those patients with recurrent mid-trimester losses due to an incompetent cervix where it is not technically possible to insert a transvaginal suture. " 07/01/1983 - "[Is surgical treatment (circular suture by Mc Donald) of milder forms of cervix incompetence advisable?]." 06/01/1980 - "[Evaluation of newborn infants delivered by women treated for cervix incompetence by circular suture using Hervet's modification]." 02/01/1978 - "A closed submucous cervical suture for the incompetent cervix."