Cerulenin

An epoxydodecadienamide isolated from several species, including ACREMONIUM, Acrocylindrum, and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.

Also Known As:

Networked: 90 relevant articles (2 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Menendez, Javier A: 5 articles (10/2007 - 03/2004)
2.	Lupu, Ruth: 4 articles (12/2006 - 03/2004)
3.	Ronnett, Gabriele V: 3 articles (02/2008 - 05/2005)
4.	Landree, Leslie E: 3 articles (02/2008 - 05/2005)
5.	Colomer, Ramon: 3 articles (10/2007 - 03/2004)
6.	Kuhajda, F P: 3 articles (07/2001 - 01/2000)
7.	Huang, P: 3 articles (12/2000 - 04/2000)
8.	Dai, Z: 3 articles (12/2000 - 04/2000)
9.	Kalff, Rolf: 2 articles (06/2014 - 08/2010)
10.	Ewald, Christian: 2 articles (06/2014 - 08/2010)

Related Diseases

1.	Starvation 02/01/2002 - "In contrast to isogenic wild-type strains and relA mutants, the 'Vibrio angustum' S14 spoT and Escherichia coli relA spoT mutants displayed significant losses in viability in response to cerulenin-induced fatty acid starvation under cool-white fluorescent light. " 02/15/1996 - "HL60 cells adapted to growth in serum- and fatty acid-free medium show a dose-dependent sensitivity to cerulenin, which is reversed by palmitate, the major product of FAS, indicating that cerulenin cytotoxicity is mediated through fatty acid starvation. " 10/01/1981 - "In contrast to the results with hadacidin-treated cells, cells in a cerulenin-induced state of growth-arrest when transferred to starvation medium exhibited the same 50 percent reduction in pinocytosis observed in cells not previously exposed to either drug. " 05/01/1981 - "Pretreatment of cultures with cerulenin prevented the inhibition of cellular synthesis autolysis normally observed during chloramphenicol treatment, but did not affect amino acid starvation-induced inhibition of autolytic activity. " 12/01/1996 - "Inhibition of phospholipid synthesis in Escherichia coli by either cerulenin treatment or glycerol starvation of a glycerol-auxotrophic mutant resulted in a concomitant block of murein synthesis. "
2.	Cryptosporidiosis 02/05/2000 - "That the discovery of CpFAS1 may provide a new biosynthetic pathway for drug development against cryptosporidiosis, is indicated by the efficacy of the FAS inhibitor cerulenin on the growth of C. "
3.	Multiple Myeloma 04/01/2007 - "To study the expression changes of apoptosis related genes induced by cerulenin in multiple myeloma cell line U266 and explore its molecular mechanism. " 10/01/2006 - "[Study on proliferation inhibiting and apoptosis inducing effects of cerulenin on multiple myeloma cells]." 06/01/2008 - "Cerulenin greatly inhibited metabolic activity/cell proliferation of U266 cells and induced apoptosis, suggesting that FAS is an effective target for pharmacological therapy in human multiple myeloma." 04/01/2007 - "[Cerulenin changes apoptosis related genes expression in multiple myeloma cell line U266]." 05/01/2008 - "This study investigated the biological significance of the inhibition of fatty acid synthase (FAS) in multiple myeloma (MM) using the small molecule inhibitor Cerulenin. "
4.	Neoplasms (Cancer) 03/01/2003 - "The antineoplastic properties of cerulenin documented here are consistent with prior studies showing its cytotoxic effects upon other types of cancer cells and illustrate the potential utility of FAS inhibition as a novel chemotherapeutic approach." 02/01/2013 - "Cerulenin is selectively toxic to human cancer cells in vitro. " 08/01/2010 - "The numbers and sizes of liver metastatic CRC tumors were significantly reduced by treating mice with cerulenin. " 03/01/2006 - "Here, we tested whether inhibition of PI3K/Akt pathway would sensitize cancer cells to cerulenin-induced apoptosis. " 03/01/2003 - "Finally, the FAS inhibitor cerulenin was investigated for its ability to suppress tumor cell growth. "
5.	Breast Neoplasms (Breast Cancer) 06/01/2012 - "We performed this study to examine the mechanism underlying apoptosis induced by cerulenin and with specific focus on its effect on HKII in ZR-75-1 human breast cancer cells. " 08/01/2004 - "SK-Br3, MCF-7 and MDA-MB-231 human breast cancer cell lines were employed as models of high, moderate and low levels of FAS ('cerulenin-target'), respectively. " 06/15/1996 - "Here, we report that cerulenin treatment of human breast cancer cells inhibits fatty acid synthesis within 6 h after exposure, that loss of clonogenic capacity occurs within the same interval, and that DNA fragmentation and morphological changes characteristic of apoptosis ensue." 05/20/1998 - "Finally, cell lines were treated with the FAS inhibitor cerulenin: almost all breast cancer lines were growth inhibited at significantly lower amounts of drug than normal cell lineages, suggesting that FAS plays a greater role in viability of tumor cells than normal cells. " 01/01/2014 - "Cerulenin, a FASN inhibitor, synergized with rapamycin to induce apoptosis and inhibit cell migration and tumorigenesis in ER/HER2-positive breast cancer cells. "

Related Drugs and Biologics

1.	Guanosine Tetraphosphate
2.	Carbon
3.	Amino Acids
4.	Adenosine Triphosphate (ATP)
5.	Fatty Acid Synthetase Complex (Fatty Acid Synthase)
6.	orlistat (Xenical)
7.	Triclosan (pHisoHex)
8.	Proteins (Proteins, Gene)
9.	Enzymes
10.	Carnitine (L-Carnitine)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Drug Therapy (Chemotherapy)