Cerulenin

An epoxydodecadienamide isolated from several species, including ACREMONIUM, Acrocylindrum, and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.

Also Known As:

Networked: 112 relevant articles (2 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Menendez, Javier A: 5 articles (10/2007 - 03/2004)
2.	Lupu, Ruth: 4 articles (12/2006 - 03/2004)
3.	Graner, Edgard: 3 articles (01/2017 - 02/2011)
4.	Landree, Leslie E: 3 articles (02/2008 - 05/2005)
5.	Ronnett, Gabriele V: 3 articles (02/2008 - 05/2005)
6.	Colomer, Ramon: 3 articles (10/2007 - 03/2004)
7.	Kuhajda, F P: 3 articles (07/2001 - 01/2000)
8.	Dai, Z: 3 articles (12/2000 - 04/2000)
9.	Huang, P: 3 articles (12/2000 - 04/2000)
10.	Coletta, Ricardo D: 2 articles (01/2017 - 02/2011)

Related Diseases

1.	Starvation 02/01/2002 - "In contrast to isogenic wild-type strains and relA mutants, the 'Vibrio angustum' S14 spoT and Escherichia coli relA spoT mutants displayed significant losses in viability in response to cerulenin-induced fatty acid starvation under cool-white fluorescent light. " 10/01/1981 - "In contrast to the results with hadacidin-treated cells, cells in a cerulenin-induced state of growth-arrest when transferred to starvation medium exhibited the same 50 percent reduction in pinocytosis observed in cells not previously exposed to either drug. " 01/01/2019 - "Indeed, the amount of TAGs in an autophagy-deficient mutant has been found to be greater than that in wild type under nitrogen starvation, and cerulenin, which is one of the inhibitors of fatty acid synthesis, induces autophagy. " 01/01/1982 - "In contrast, uracil uptake was slower in hadacidin-treated cells as opposed to starvation or cerulenin-induced growth-arrest cells. " 01/01/1982 - "The rate of fucose uptake was the same for starvation or hadacidin-induced growth-arrest, but significantly lower for cerulenin-treated cells. "
2.	Cryptosporidiosis 02/05/2000 - "That the discovery of CpFAS1 may provide a new biosynthetic pathway for drug development against cryptosporidiosis, is indicated by the efficacy of the FAS inhibitor cerulenin on the growth of C. "
3.	Neoplasms (Cancer) 08/23/2016 - "Mice were injected with cerulenin or vehicle after tumors were developed. " 02/01/2013 - "Cerulenin is selectively toxic to human cancer cells in vitro. " 08/01/2010 - "The numbers and sizes of liver metastatic CRC tumors were significantly reduced by treating mice with cerulenin. " 03/01/2006 - "Here, we tested whether inhibition of PI3K/Akt pathway would sensitize cancer cells to cerulenin-induced apoptosis. " 03/01/2003 - "Finally, the FAS inhibitor cerulenin was investigated for its ability to suppress tumor cell growth. "
4.	Breast Neoplasms (Breast Cancer) 10/29/2022 - "In this study, we systematically investigate the inhibitory effects of cerulenin on proliferation, migration, invasion and glycolysis of ErbB2-overexpressing breast cancer cells and its molecular mechanism. " 10/29/2022 - "Our previous study found that cerulenin inhibits the glycolysis and migration of SK-BR-3 cells, but the effect of cerulenin on other malignant phenotypes of breast cancer is still unknown. " 06/01/2012 - "We performed this study to examine the mechanism underlying apoptosis induced by cerulenin and with specific focus on its effect on HKII in ZR-75-1 human breast cancer cells. " 10/29/2022 - "These findings illustrated that cerulenin inhibits proliferation, migration, invasion and glycolysis by targeting ErbB2/PKM2 pathway in ErbB2-overexpressing breast cancer cells." 10/29/2022 - "Cerulenin suppresses ErbB2-overexpressing breast cancer by targeting ErbB2/PKM2 pathway."
5.	Multiple Myeloma 04/01/2007 - "To study the expression changes of apoptosis related genes induced by cerulenin in multiple myeloma cell line U266 and explore its molecular mechanism. " 10/01/2006 - "[Study on proliferation inhibiting and apoptosis inducing effects of cerulenin on multiple myeloma cells]." 04/01/2007 - "[Cerulenin changes apoptosis related genes expression in multiple myeloma cell line U266]." 06/01/2008 - "Cerulenin greatly inhibited metabolic activity/cell proliferation of U266 cells and induced apoptosis, suggesting that FAS is an effective target for pharmacological therapy in human multiple myeloma." 05/01/2008 - "This study investigated the biological significance of the inhibition of fatty acid synthase (FAS) in multiple myeloma (MM) using the small molecule inhibitor Cerulenin. "

Related Drugs and Biologics

1.	Fatty Acids (Saturated Fatty Acids)
2.	Phospholipids (Phosphatides)
3.	Amino Acids
4.	Guanosine Tetraphosphate
5.	Carbon
6.	Adenosine Triphosphate (ATP)
7.	Fatty Acid Synthases (Fatty Acid Synthase)
8.	Orlistat (Xenical)
9.	Antineoplastic Agents (Antineoplastics)
10.	Enzymes

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)