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Cerebrovascular Disorders (Cerebrovascular Occlusion)

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A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES; or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.

Also Known As:

Cerebrovascular Occlusion; Cerebrovascular Insufficiency; Brain Vascular Disorder; Cerebrovascular Disorder; Cerebrovascular Insufficiencies; Cerebrovascular Occlusions; Insufficiencies, Cerebrovascular; Insufficiency, Cerebrovascular; Intracranial Vascular Disease; Intracranial Vascular Diseases; Intracranial Vascular Disorder; Occlusion, Cerebrovascular; Occlusions, Cerebrovascular; Vascular Disease, Intracranial; Vascular Disorder, Brain; Vascular Disorder, Intracranial; Vascular Disorders, Brain; Vascular Disorders, Intracranial; Brain Vascular Disorders; Intracranial Vascular Disorders; Vascular Diseases, Intracranial

Networked: 628 relevant articles (25 outcomes, 72 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Stroke (Strokes)
2.	Vertigo (Positional Vertigo)
3.	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage)
4.	Tinnitus
5.	Alzheimer Disease (Alzheimer's Disease)

Experts

1.	Chukanova, E I: 3 articles (01/2009 - 01/2005)
2.	Lominadze, David: 3 articles (01/2008 - 04/2002)
3.	Tamargo, Rafael J: 2 articles (04/2015 - 10/2006)
4.	Levy, E I: 2 articles (03/2015 - 05/2007)
5.	Evdokimov, A G: 2 articles (01/2015 - 01/2015)
6.	Nosenko, E M: 2 articles (01/2015 - 01/2015)
7.	Shmyrev, V I: 2 articles (01/2015 - 01/2015)
8.	Nosenko, N S: 2 articles (01/2015 - 01/2015)
9.	Romanova, M S: 2 articles (01/2015 - 01/2015)
10.	Yang, Li: 2 articles (01/2015 - 12/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cerebrovascular Disorders:

1.	CyclandelateIBA 10/01/1984 - "Chronic cerebrovascular disorders: a clinical study with cyclandelate." 01/01/1984 - "Clinical effects of Cyclospasmol in patients affected by chronic cerebrovascular disorders." 01/01/1987 - "Thus, when used in the setting of general practice, cyclandelate seems to be a safe and apparently effective treatment for patients with symptoms of vertigo, tinnitus and visual disturbances attributable to chronic cerebrovascular insufficiency." 01/01/1987 - "To investigate the perceived efficacy and safety of cyclandelate when used in general practice, an open multicentre study was performed comprising 2772 patients with symptoms of vertigo, tinnitus or visual disturbances thought to result from cerebrovascular insufficiency. " 01/01/1987 - "Perceived efficacy of cyclandelate in the treatment of cochleovestibular and retinal disturbances related to cerebrovascular insufficiency. "
2.	Retinaldehyde (Retinal)IBA 03/01/2004 - "Studying pathological changes of retinal blood vessels (microaneurysms, retinal haemorrhages, and retinal arteriolar narrowing) may help to understand the causes of various cerebrovascular disorders. " 05/01/1985 - "Retinal fluorangiographic techniques can be employed in the study of cerebrovascular disorders in relation to the embryological, anatomic and functional affinities between the cerebral and retinal circulation. " 03/01/2004 - "Future research should be aimed at the development of standardised photographic methods for the assessment of retinal microvascular changes, the replication of these findings in other populations and in people with other cerebrovascular disorders, and the examination of the increased accuracy of stoke-risk stratification given by retinal photography" 01/01/1984 - "The authors analyse the main pathogenic hypothesis of neovascular glaucoma, and suggest that it could be the result of the concurrent action of posterior ocular alterations (like retinal ischaemia following a branch retinal vein occlusion) and of cerebrovascular insufficiency. " 01/01/1987 - "Perceived efficacy of cyclandelate in the treatment of cochleovestibular and retinal disturbances related to cerebrovascular insufficiency. "
3.	Pyrithioxin (Pyritinol)IBA 01/01/1980 - "The results of a series of multicentre, controlled, double-blind trials of the clinical efficacy of Encephabol compared with placebo in patients with a variety of cerebrovascular disorders are reported." 01/01/1980 - "Clinical effect of Encephabol (pyritinol) in the treatment of cerebrovascular disorders." 01/01/1981 - "The therapeutic efficacy of GABA was compared with pyrithioxine and placebo in 432 patients with cerebrovascular disorders by a multi-center (50 hospitals) double-blind clinical trial. " 01/01/2014 - "Therefore, joint effects of vinpocetine and pyritinol improve blood and plasma viscosity in patients with cerebrovascular disorders. "
4.	FlunarizineIBA 01/01/1984 - "In preliminary placebo-controlled studies there was some evidence that flunarizine may improve impaired cognitive function in patients with cerebrovascular disorders, but such findings need further confirmation in additional carefully conducted studies. " 01/01/1988 - "Randomized double-blind study of flunarizine versus placebo in patients with chronic cerebrovascular disorders." 09/30/1984 - "[Flunarizine in the therapy of chronic cerebrovascular insufficiency. " 02/01/1982 - "[Effects of flunarizine on chronic cerebrovascular insufficiency: experience of a geriatric department]." 10/01/1989 - "Placebo-controlled studies show that flunarizine is effective in the treatment of vertigo and associated symptoms of either peripheral or central origin, and in the treatment of cerebrovascular insufficiency where psychological symptoms, rather than vertigo, are the primary symptoms. "
5.	eburnamonine (vinburnine)IBA 09/01/1986 - "In the first study, the efficacy of 12 weeks of administration of 3 X 60 mg Eburnamonine per day (n = 25) was investigated in 49 inpatients with cerebrovascular disorders. " 09/01/1986 - "Experimental clinical studies on the effect of eburnamonine in cerebrovascular disorders." 01/01/1978 - "The authors have made a study of CBF after (-)eburnamonine infusion, during angiographic examination of 6 patients with cerebrovascular insufficiency, for a hemodynamic evaluation of the drug efficacy on CBF. " 11/01/1980 - "[Electrophysiological variations induced by (-) eburnamonine in patients with chronic cerebrovascular insufficiency]." 08/01/1980 - "[Clinical evaluation of (-) eburnamonine in chronic cerebrovascular insufficiency]."
6.	buflomedil (Lofton)IBA 11/01/1989 - "[Whole blood filterability in chronic cerebrovascular disorders: effects of the use of buflomedil hydrochloride]." 09/22/1985 - "Research has been carried out into the effects of a new vasoactive substance, buflomedil hydrochloride, on two groups of patients suffering from cerebrovascular insufficiency and obliterating arteriopathy at the lower extremities. " 09/22/1985 - "[Treatment of chronic cerebrovascular insufficiency and chronic obliterating arteriopathy of the lower extremities with buflomedil hydrochloride]." 07/14/1983 - "[Effect of buflomedil on the behavior of platelet aggregation and its clinical evaluation in elderly patients with chronic cerebrovascular insufficiency]." 05/01/1987 - "Thus, buflomedil would seem to be a useful adjunct to conservative treatment in patients with mild-to-moderate peripheral vascular disease and/or cerebrovascular insufficiency, and well worth a try in patients with more severe peripheral disease unable to undergo surgery. "
7.	Estrogens (Estrogen)FDA Link 01/01/2009 - "Beneficial effects of estrogen in a mouse model of cerebrovascular insufficiency." 11/01/1978 - "In the absence of other predisposing factors in this case, it appears that the cerebrovascular occlusion was related to estrogen administration. " 02/01/2003 - "The effect of postmenopausal estrogen replacement therapy (ERT) on the risk or severity of cerebrovascular disorders is as yet unclear, and the evidence for flow preservation being a mechanism of estrogen neuroprotection remains elusive. " 10/01/1999 - "A number of studies indicate that the female gonadal hormone, estrogen, confers protection against cerebrovascular disorders such as stroke. "
8.	Nicardipine (Dagan)FDA LinkGeneric 07/01/1991 - "It is concluded that the daily administration of nicardipine is safe and effective in outpatients with cerebrovascular disorders." 10/01/1996 - "The results of a large number of studies in cerebrovascular insufficiency suggest that nicardipine, may favourably affect the cerebral circulation and may improve the patient's cognitive function. " 07/01/1991 - "Nicardipine in the treatment of outpatients with cerebrovascular disorders." 02/22/1986 - "[Does nicardipine improve chronic cerebrovascular insufficiency?]."
9.	HormonesIBA 11/01/1978 - "The occurrence of persistent severe headaches in patients using estrogenic hormones may be a clue to impending cerebrovascular occlusion." 10/01/1999 - "A number of studies indicate that the female gonadal hormone, estrogen, confers protection against cerebrovascular disorders such as stroke. " 06/01/2009 - "Adiponectin (APN), a circulating adipose-derived hormone regulating inflammation and energy metabolism, has beneficial actions on cardio- and cerebrovascular disorders. "
10.	Ergot AlkaloidsIBA 03/20/1970 - "Dihydrogenated ergot alkaloids (Hydergine) and cerebrovascular insufficiency." 01/01/1985 - "Seventy-six patients took part in a randomized, comparative study of the efficacy of buflomedil hydrochloride and dihydrogenated ergot alkaloids in the treatment of senile dementia associated with cerebrovascular insufficiency. " 01/01/1985 - "In conclusion, buflomedil is as effective or more effective than dihydrogenated ergot alkaloids in the treatment of senile dementia associated with cerebrovascular insufficiency and could prove a valuable addition to long-term therapy if further studies support the trend shown in this study." 01/01/1985 - "The treatment of senile dementia associated with cerebrovascular insufficiency: a comparative study of buflomedil and dihydrogenated ergot alkaloids."

Therapies and Procedures

1.	Carotid Endarterectomy 01/01/2015 - "The study was aimed at examining efficacy of preoperative preparation (pharmacological preconditioning) for carotid endarterectomy in patients with chronic cerebrovascular insufficiency. " 01/01/2015 - "Clinical and ultrasonic markers of postoperative complications of carotid endarterectomy in patients with cerebrovascular insufficiency." 01/01/2015 - "For the period from 2007 to 2012 carotid endarterectomy was performed in 150 patients with cerebrovascular insufficiency I-IV degrees and atherosclerotic lesion of carotid arteries. " 01/01/2011 - "Carotid endarterectomy (CEAE) is currently considered to be one of the most efficient methods of treatment for chronic cerebrovascular insufficiency and prevention of recurrent acute impairments of cerebral blood supply. " 07/01/2004 - "It is widely accepted and proved the role of carotid endarterectomy in the prevention of cerebrovascular insufficiency. "
2.	Drug Therapy (Chemotherapy) 01/01/1988 - "[Pharmacotherapy of chronic cerebrovascular insufficiency]." 01/01/1988 - "[Pharmacotherapy of acute cerebrovascular insufficiency]." 03/01/1981 - "[Cerebrovascular insufficiency and compliance with drug therapy]." 01/01/1973 - "[Prognosis and drug therapy in ischemic cerebrovascular disorders]." 01/01/1964 - "[GENERAL PRINCIPLES IN THE DRUG THERAPY OF CEREBROVASCULAR DISORDERS]."
3.	Thrombolytic Therapy 01/01/2015 - "Although IVtPA is easily administered and is effective in many cases, the clinical condition of some patients can worsen after the initiation of thrombolytic therapy due to sustained cerebrovascular insufficiency. " 12/16/1999 - "[Thrombolytic therapy of cerebrovascular disorders]." 01/01/1992 - "Thrombolytic therapy in cerebrovascular disorders." 01/01/1965 - "THROMBOLYTIC THERAPY IN CEREBROVASCULAR OCCLUSION." 04/01/2015 - "Targeting therapeutics across the blood brain barrier (BBB), prerequisite towards thrombolytic therapy for cerebrovascular disorders-an overview and advancements."
4.	Oral Administration 01/01/1983 - "These results show that the daily oral administration of 6 mg of DEM is more suitable for the improvement of subjective and psychiatric symptoms due to cerebrovascular disorders than is the daily sublingual administration of 3 mg. These results suggest that, despite much complexity in the neurohumoral transmitter mechanism in the brain, relatively simple dose-dependent efficacy of the drug in the range of the therapeutic doses was confirmed for many subjective and psychiatric symptoms of patients with cerebrovascular disorders." 01/01/1998 - "Thus, the oral administration of Dotarizine might have effect on the various parts of the cerebrovascular system and can play significant role in improvement of various cerebrovascular disorders."
5.	Sublingual Administration 01/01/1983 - "These results show that the daily oral administration of 6 mg of DEM is more suitable for the improvement of subjective and psychiatric symptoms due to cerebrovascular disorders than is the daily sublingual administration of 3 mg. These results suggest that, despite much complexity in the neurohumoral transmitter mechanism in the brain, relatively simple dose-dependent efficacy of the drug in the range of the therapeutic doses was confirmed for many subjective and psychiatric symptoms of patients with cerebrovascular disorders."