Intracranial Arteriovenous Malformations (Cerebral Arteriovenous Malformation)

Congenital vascular anomalies in the brain characterized by direct communication between an artery and a vein without passing through the CAPILLARIES. The locations and size of the shunts determine the symptoms including HEADACHES; SEIZURES; STROKE; INTRACRANIAL HEMORRHAGES; mass effect; and vascular steal effect.

Also Known As:

Cerebral Arteriovenous Malformation; Arteriovenous Malformation, Cerebral; AVM (Arteriovenous Malformation) Intracranial; Cerebral Arteriovenous Malformations; Congenital Intracranial Arteriovenous Malformations; Intracranial Arteriovenous Malformation, Ruptured; Ruptured Intracranial Arteriovenous Malformation; Arteriovenous Malformation, Intracranial; Arteriovenous Malformations, Intracranial; Intracranial Arteriovenous Malformation; Malformation, Cerebral Arteriovenous; Malformation, Intracranial Arteriovenous; Malformations, Cerebral Arteriovenous; Malformations, Intracranial Arteriovenous; Arteriovenous Malformations, Cerebral; Intracranial Arteriovenous Malformations, Congenital

Networked: 506 relevant articles (15 outcomes, 37 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hemorrhage
2.	Neoplasms (Cancer)
3.	Sepsis (Septicemia)
4.	Wounds and Injuries (Trauma)
5.	Pancreatitis

Experts

1.	Starke, Robert M: 8 articles (06/2016 - 08/2008)
2.	Ogilvy, Christopher S: 7 articles (11/2021 - 08/2003)
3.	Takagi, Yasushi: 7 articles (05/2020 - 04/2006)
4.	Ding, Dale: 6 articles (06/2016 - 06/2014)
5.	Hashimoto, Nobuo: 6 articles (11/2012 - 04/2006)
6.	Loeffler, Jay S: 5 articles (06/2016 - 08/2003)
7.	Spetzler, Robert F: 5 articles (02/2015 - 09/2009)
8.	Connolly, E Sander: 5 articles (09/2011 - 10/2006)
9.	Young, W L: 5 articles (11/2001 - 01/2000)
10.	Matsumoto, Yasushi: 4 articles (01/2022 - 01/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Intracranial Arteriovenous Malformations:

1.	Indocyanine Green (Cardio-Green)FDA LinkGeneric 01/01/2023 - "Efficacy of Utilizing Both 3-Dimensional Multimodal Fusion Image and Intra-Arterial Indocyanine Green Videoangiography in Cerebral Arteriovenous Malformation Surgery." 05/22/2020 - "Efficacy of intraarterial superselective indocyanine green videoangiography in cerebral arteriovenous malformation surgery in a hybrid operating room." 02/01/2015 - "Efficacy of FLOW 800 with indocyanine green videoangiography for the quantitative assessment of flow dynamics in cerebral arteriovenous malformation surgery." 12/01/2014 - "In reply: can the efficacy of indocyanine green videoangiography in cerebral arteriovenous malformations surgery be further improved?" 02/01/2023 - "Evaluation of the Utility of Indocyanine Green Video Angiography in Cerebral Arteriovenous Malformation Surgery."
2.	EnbucrilateIBA 01/01/2022 - "To clarify the safety and efficacy of pre-operative embolization using Onyx liquid embolic agent (Onyx; ev3) compared with N-butyl cyanoacrylate (NBCA; Cordis Neurovascular, Inc.) or coils in cerebral arteriovenous malformation (AVM) surgery. " 10/01/2010 - "A prospective, multicenter, randomized trial of the Onyx liquid embolic system and N-butyl cyanoacrylate embolization of cerebral arteriovenous malformations. " 05/01/2002 - "N-butyl cyanoacrylate embolization of cerebral arteriovenous malformations: results of a prospective, randomized, multi-center trial." 07/01/1997 - "The aim of this study was to determine the usefulness of preoperative embolisation of intracranial arteriovenous malformations (AVMs) with N-Butylcyanoacrylate (NBCA) since the introduction of this interventional neuroradiology technique in March 1994 at Tan Tock Seng Hospital, Singapore. " 03/01/2021 - "Endovascular embolization of cerebral arteriovenous malformations (AVM) with liquid n-butyl cyanoacrylate (n-BCA) serves multiple purposes including AVM occlusion and flow reduction in preparation for other treatment modalities. "
3.	Silk FDA Link 08/01/1997 - "To evaluate the safety of silk as an embolic agent for preoperative embolization of cerebral arteriovenous malformations (AVMs) by assessing the histopathologic changes and hemorrhagic complications associated with its use. " 08/01/1997 - "Embolization of cerebral arteriovenous malformations with silk: histopathologic changes and hemorrhagic complications." 08/01/1991 - "[Transcatheter injection of silk particulates and line segments in the treatment of cerebral arteriovenous malformations]." 02/01/1994 - "To evaluate the safety and efficacy of silk suture as an agent for preoperative embolization of cerebral arteriovenous malformations. " 06/01/2000 - "The aim of this study was to determine the incidence and clinical significance of complications related to preoperative embolization of cerebral arteriovenous malformations (AVMs) with silk sutures as documented on postprocedure computerized tomography (CT) scans. "
4.	Adenosine (Adenocard)FDA LinkGeneric 10/01/2021 - "Adenosine-induced transient circulatory arrest in transvenous embolization of cerebral arteriovenous malformations." 04/01/2021 - "There are no reports that describe complete flow control using concurrent transient rapid ventricular pacing or intravenous (IV) adenosine and afferent arterial balloon flow arrest to aid transvenous embolization of cerebral arteriovenous malformations (AVM). " 04/01/2021 - "Complete flow control using transient concurrent rapid ventricular pacing or intravenous adenosine and afferent arterial balloon occlusion during transvenous embolization of cerebral arteriovenous malformations: case series." 07/01/2009 - "Adenosine-induced cardiac standstill to facilitate endovascular embolisation of cerebral arteriovenous malformations in children." 04/01/1999 - "Adenosine-induced cardiac pause for endovascular embolization of cerebral arteriovenous malformations: technical case report."
5.	Polyvinyl AlcoholIBA 05/01/1990 - "Embolization results in cerebral arteriovenous malformations were improved with superselective catheterization and most improved with the combined use of polyvinyl alcohol for nidus embolization followed by occlusion of the feeding vessel with microcoils." 08/01/1999 - "Embolization of cerebral arteriovenous malformations achieved with polyvinyl alcohol particles: angiographic reappearance and complications." 08/01/1995 - "Delayed recanalization of a cerebral arteriovenous malformation following angiographic obliteration with polyvinyl alcohol embolization." 04/01/1993 - "An iatrogenic complication of transcatheter embolization of a cerebral arteriovenous malformation with polyvinyl alcohol sponge." 05/01/1990 - "Preoperative embolization of cerebral arteriovenous malformations with polyvinyl alcohol particles: experience in 51 adults."
6.	Angiogenesis InhibitorsIBA 10/04/2019 - "Antiangiogenic agent as a novel treatment for pediatric intracranial arteriovenous malformations: case report."
7.	Factor VIIa (Activated Factor VII)IBA 11/01/2009 - "Recently, a growing number of case reports and case series have suggested that the use of recombinant activated factor VII (rFVIIa) may be effective in treatment of patients with non-hemophilic acquired coagulopathy not responding to conventional treatment such as major surgery, major trauma, sepsis, necrotizing pancreatitis and bleeding due to cerebral arteriovenous malformations. "
8.	Nitroglycerin (Dynamite)FDA LinkGeneric 01/01/2023 - "Case report: A combination of nitroglycerin and adenosine proves effective in repairing a cerebral arteriovenous malformation."
9.	recombinant FVIIa (rFVIIa)FDA Link 11/01/2009 - "Recently, a growing number of case reports and case series have suggested that the use of recombinant activated factor VII (rFVIIa) may be effective in treatment of patients with non-hemophilic acquired coagulopathy not responding to conventional treatment such as major surgery, major trauma, sepsis, necrotizing pancreatitis and bleeding due to cerebral arteriovenous malformations. "
10.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/01/1996 - "Expression of vascular endothelial growth factor in pediatric and adult cerebral arteriovenous malformations: an immunocytochemical study." 06/01/2014 - "Role of vascular endothelial growth factor in the pathophysiology of intracranial arteriovenous malformations." 01/01/2006 - "Vascular endothelial growth factor plasma levels are significantly elevated in patients with cerebral arteriovenous malformations." 08/01/2008 - "Plasma levels of vascular endothelial growth factor after treatment for cerebral arteriovenous malformations." 08/26/2013 - "The present study suggests that hypoxic endothelial cells from the nidus of human cerebral arteriovenous malformation (CAVMECs) have angiogenic potentials, as our data showed that VEGF gene expression and cell proliferation were more evident with prolonged hypoxia. "

Therapies and Procedures

1.	Therapeutics 01/01/1998 - "Embolization of cerebral arteriovenous malformations (AVMs)--material selection, improved technique, and tactics in the initial therapy of cerebral AVMs." 08/01/2023 - "Recently, there has been a shift in management of unruptured cerebral arteriovenous malformations (AVMs) following studies suggesting that medical management alone was superior to interventional therapy. " 10/01/2023 - "Complex cerebral arteriovenous malformations (AVMs) require a combined therapy of endovascular embolization and microsurgical resection to eliminate the lesion and maximize neurological protection, while a deliberate time interval might contribute to optimal clinical outcomes. " 12/01/2022 - "Clinical Characteristics and Multimodality Therapy Outcomes in 304 Pediatric Patients with Cerebral Arteriovenous Malformations." 01/01/2018 - "Endovascular treatment of small cerebral arteriovenous malformations as a primary therapy."
2.	Catheters 03/01/1998 - "Improved technique for liquid embolization of cerebral arteriovenous malformation: catheter-tip position and flow control." 01/01/2018 - "In the other patient with cerebral arteriovenous malformation (AVM), microcatheters for AVM without a proximal marker were used for coil embolization before Onyx injection: Coil embolization was applied through one microcatheter to a site more proximal than the tip of the other microcatheter, followed by Onyx injection through the distal catheter, by which the nidus was continuously penetrated from the initiation of injection, obtaining an effect similar to that of the plug and push technique. " 11/01/2015 - "We compared HYPR flow and time-resolved imaging of contrast kinetics (TRICKS) MRA for the characterization of cerebral arteriovenous malformations (cAVMs), using catheter DSA as reference. " 11/01/2015 - "Interest of HYPR flow dynamic MRA for characterization of cerebral arteriovenous malformations: comparison with TRICKS MRA and catheter DSA." 01/01/2014 - "CT-guided, frameless radiosurgery is an alternative treatment to traditional catheter-angiography targeted, frame-based methods for intracranial arteriovenous malformations (AVMs). "
3.	Sutures (Suture) 02/01/1994 - "To evaluate the safety and efficacy of silk suture as an agent for preoperative embolization of cerebral arteriovenous malformations. " 06/01/2000 - "The aim of this study was to determine the incidence and clinical significance of complications related to preoperative embolization of cerebral arteriovenous malformations (AVMs) with silk sutures as documented on postprocedure computerized tomography (CT) scans. " 06/01/2016 - "Preoperative Embolization of Cerebral Arteriovenous Malformations with Silk Suture and Particles: Technical Considerations and Outcomes." 10/01/2015 - "Embolization of cerebral arteriovenous malformations with silk suture particles prior to stereotactic radiosurgery." 06/01/2000 - "Preoperative embolization of cerebral arteriovenous malformations with silk sutures: analysis and clinical correlation of complications revealed on computerized tomography scanning."
4.	Particle Accelerators 11/25/2022 - "Long-term follow-up of an overexposure radiation incident in a cohort treated with linear accelerator-based stereotactic radiosurgery for intracranial arteriovenous malformations." 09/01/2020 - "To analyze and report the long-term outcomes of intracranial arteriovenous malformations (AVM) treated with linear accelerator (LINAC)-based radiosurgery (LBRS) in the pediatric population. " 09/01/2020 - "Pediatric Intracranial Arteriovenous Malformation: Long-Term Outcomes with Linear Accelerator (LINAC)-Based Radiosurgery." 11/01/2016 - "To evaluate the obliteration rate and clinical outcome following linear accelerator (LINAC)-based stereotactic radiosurgery (SRS) for intracranial arteriovenous malformation (AVM) in pediatric patients (age ≤18 years). " 11/01/2016 - "Results of a Conservative Dose Plan Linear Accelerator-Based Stereotactic Radiosurgery for Pediatric Intracranial Arteriovenous Malformations."
5.	Liver Transplantation 12/21/2021 - "Spontaneous resolution of cerebral arteriovenous malformation after liver transplant: illustrative case." 06/01/2011 - "[Spontaneous disappearance of intracranial arteriovenous malformation after living-donor liver transplantation: a case report]." 10/01/2021 - "Cerebrovascular diseases, such as cerebral arteriovenous malformation (AVM), are a leading cause of death following a liver transplant. " 06/01/2011 - "In this report, the authors describe a 35-year-old male whose intracranial arteriovenous malformation (AVM) spontaneously disappeared about 2 years after successful living-donor liver transplantation for alcohol-induced liver cirrhosis. "