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Cerebellar Diseases (Cerebellar Syndrome)

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Diseases that affect the structure or function of the cerebellum. Cardinal manifestations of cerebellar dysfunction include dysmetria, GAIT ATAXIA, and MUSCLE HYPOTONIA.

Also Known As:

Cerebellar Syndrome; Cerebellar Disorders; Cerebellar Syndromes; Cerebellar Disease; Cerebellar Disorder; Cerebellar Dysfunctions; Cerebellum Disease; Disease, Cerebellar; Disease, Cerebellum; Disorder, Cerebellar; Dysfunction, Cerebellar; Syndrome, Cerebellar; Cerebellar Dysfunction; Cerebellum Diseases

Networked: 385 relevant articles (16 outcomes, 22 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Bronchogenic Carcinoma
2.	Cerebellar Ataxia (Dysmetria)
3.	Abducens Nerve Diseases (Sixth Nerve Palsy)
4.	Gait Ataxia
5.	Polyneuropathies (Polyneuropathy)

Experts

1.	Strupp, Michael: 4 articles (04/2015 - 01/2008)
2.	Stahl, John S: 4 articles (11/2014 - 04/2005)
3.	Brandt, Thomas: 3 articles (04/2015 - 01/2008)
4.	Walkley, Steven U: 3 articles (02/2015 - 12/2010)
5.	Davidson, Cristin: 3 articles (02/2015 - 12/2010)
6.	Paulose, C S: 3 articles (07/2011 - 11/2009)
7.	Muth, C: 2 articles (09/2015 - 09/2014)
8.	Strupp, M: 2 articles (09/2015 - 09/2014)
9.	Böttcher, N: 2 articles (09/2015 - 09/2014)
10.	Kremmyda, O: 2 articles (09/2015 - 09/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cerebellar Diseases:

1.	rituximab (Mabthera)FDA Link 06/01/2012 - "Based on promising data in adults on the efficacy of rituximab over other immuno suppressive agents in paraneoplastic disorders, he was treated with rituximab with marked improvement of the cerebellar syndrome." 08/01/2009 - "Favorable response to rituximab in a patient with anti-VGCC-positive Lambert-Eaton myasthenic syndrome and cerebellar dysfunction." 12/01/2013 - "We report a case of PCD associated with gastric diffuse large B-cell lymphoma (DLBCL) in a patient who presented with acute onset of giddiness and double vision and had complete remission of the gastric lesion and marked improvement of cerebellar syndrome with rituximab-based combination chemotherapy. "
2.	Levodopa (L Dopa)FDA LinkGeneric 11/01/2004 - "He has remained responsive to levodopa 14 years after onset and has had no overt signs suggesting cerebellar dysfunction. " 03/01/2004 - "The treatment with l-dopa was effective in patient 3, but non-effective in patient 2. Brain MRI revealed multiple high signal intensities over the subcortical white matter, basal ganglia, and/or even the brainstem in patients 1 and 2, but normal in patient 3. In DAT studies, the bindings were normal in patients 1 and 2 and was decreased in patient 3. We conclude that CS(2) exposure may induce polyneuropathy, and cerebellar dysfunction in addition to parkinsonian features and that brain MRI may show multiple lesions in the cerebral white matter and basal ganglia. " 09/01/2000 - "Difficulties encountered in establishing MSA clinical diagnosis criteria were, among others, the variable expression of the disease, the definition of autonomic failure, of the cerebellar syndrome and of the poor levodopa response of parkinsonism. " 12/01/1995 - "Helpful early points to the diagnosis included rigid-akinetic type, rapid progression, failure to respond to L-DOPA and other signs such as autoromic dysfunction, cerebellar ataxia and pyramidal signs, but these were not always present. " 01/01/2014 - "Though disrupted predictive control is typical of patients with cerebellar disease, sensorimotor deficits associated with the involuntary and often unconscious nature of l-DOPA-induced dyskinesias in Parkinson's disease (PD) suggests dyskinetic subjects may also demonstrate impaired predictive motor control. "
3.	Acetazolamide (Diamox)FDA LinkGeneric 12/01/2015 - "The main findings are: (1) diagnostic criteria for pseudotumor cerebri have been updated, and the Idiopathic Intracranial Hypertension Treatment Trial evaluated the efficacy of acetazolamide in patients with mild vision loss, (2) categorization of vestibular disorders through history and ocular motor examination is particularly important in the acute vestibular syndrome, where timely distinction between a central or peripheral localization is essential, (3) the newly described "sagging eye syndrome" provides a mechanical explanation for an isolated esodeviation that increases at distance in the aging population and (4) eye movement recordings better define how cerebellar dysfunction and/or sixth nerve palsy may play a role in other patients with esodeviations that increase at distance. "
4.	AntibodiesIBA 07/01/2011 - "Therefore, it was hypothesized that P/Q-VGCC antibodies may induce cerebellar dysfunction after entering the CNS in patients with PCD-LEMS. " 03/09/2004 - "Patients with isolated Zic4 antibodies are more likely to develop cerebellar dysfunction than those with concurrent immunities." 03/09/2004 - "Patients with isolated Zic4 antibodies were more likely to develop predominant cerebellar dysfunction than patients with several immunities (p < 0.001). " 09/10/2002 - "VGCC antibodies should be looked for in PCD, even if there are no symptoms of LEMS, and may be related to the cerebellar dysfunction." 04/01/1997 - "Patients with cerebellar disorders without HD (159) or HD without PCD (30) did not harbor anti-Tr antibodies. "
5.	Episodic ataxia with nystagmusIBA 11/01/2012 - "In addition, the profiles of three participants with a rare autosomal dominant cerebellar disease were assessed (episodic ataxia type 2, EA-2). " 01/01/2010 - "Episodic ataxia type 2 (EA2) is characterized by paroxysmal bouts of ataxia and progressive cerebellar dysfunction. " 04/01/2006 - "Episodic ataxia type 2 (EA2) is an inherited autosomal dominant disorder related to cerebellar dysfunction and is associated with mutations in the pore-forming alpha(1A)-subunits of human P/Q-type Ca(2+) channels (Cav2.1 channels). " 04/01/2006 - "Downbeat nystagmus (DBN) is caused by cerebellar disease, which includes structural lesions affecting the flocculus and paraflocculus, and calcium channelopathies, such as episodic ataxia type 2 (EA2), for which a mouse model and effective treatment is available. " 04/01/2013 - "The reversible potassium channel blocker 4-aminopyridine is effective in the treatment of numerous cerebellar dysfunctions, such as episodic ataxia type 2 and downbeat nystagmus syndrome. "
6.	Intravenous Immunoglobulins (IVIG)FDA Link 07/01/2005 - "Treatment with diazepam rapidly improved Stiff-person symptoms, whereas IVIg was partially effective at the early stage of cerebellar dysfunction." 09/01/2008 - "This is a report about an immunocompetent 4-year-old female child affected with acute encephalitis by parvovirus B19, documented by polymerase chain reaction performed on cerebrospinal fluid, who was treated with intravenous immunoglobulins and dexamethasone and who developed a cerebellar syndrome with ataxia, dysmetria, and dysarthria. "
7.	4-Aminopyridine (4 Aminopyridine)IBA 04/01/2013 - "The reversible potassium channel blocker 4-aminopyridine is effective in the treatment of numerous cerebellar dysfunctions, such as episodic ataxia type 2 and downbeat nystagmus syndrome. "
8.	Potassium Channels (Potassium Channel)IBA 04/01/2013 - "The reversible potassium channel blocker 4-aminopyridine is effective in the treatment of numerous cerebellar dysfunctions, such as episodic ataxia type 2 and downbeat nystagmus syndrome. "
9.	Estrogens (Estrogen)FDA Link 08/15/2008 - "Buspirone, a 5-HT1(A) agonist could constitute a symptomatic improvement in cerebellar dysfunction whereas estrogen has been investigated for neuroprotection. " 08/15/2008 - "Buspirone treatment showed feasible efficacies for OPCA, while the combined treatment of estrogen and buspirone failed to improve, suggesting estrogen may not have further benefit in cerebellar dysfunction."
10.	Diazepam (Valium)FDA LinkGeneric 07/01/2005 - "Treatment with diazepam rapidly improved Stiff-person symptoms, whereas IVIg was partially effective at the early stage of cerebellar dysfunction."

Therapies and Procedures

1.	Pneumonectomy (Lung Volume Reduction) 06/05/1980 - "Remission of cerebellar dysfunction after pneumonectomy for bronchogenic carcinoma." 06/05/1980 - "Remission of cerebellar dysfunction after pneumonectomy for bronchogenic carcinoma." 01/17/1980 - "Remission of cerebellar dysfunction after pneumonectomy for bronchogenic carcinoma."
2.	Activities of Daily Living (ADL) 06/01/2012 - "To investigate short- and long-term effects of intensive rehabilitation on ataxia, gait, and activities of daily living (ADLs) in patients with degenerative cerebellar disease. " 06/01/2012 - "Cerebellar Ataxia Rehabilitation trial tested if intensive rehabilitation improved ataxia, gait, and activities of daily living (ADLs) in 42 patients with degenerative cerebellar diseases. " 12/01/2006 - "The most common abnormal neurologic findings on admission were altered consciousness (47.6%), followed by abnormal activities of daily living (52.4%), cerebellar dysfunction (17.5%), and cranial nerve palsy (15.9%). "
3.	Transplants (Transplant) 01/01/2012 - "As all these effects were accompanied by a temporal but significant improvement in motor coordination, HuUCBMCs grafts can be considered as an effective cell replacement therapy for cerebellar disorders." 01/01/2013 - "The high frequency of clinical manifestations related to brain stem and cerebellar dysfunction in the non-plaque type dCJD with infratentorial grafting suggests that PrP(Sc) commonly shows direct propagation into the CNS from contaminated dura mater grafts." 07/01/1991 - "However, more complex neurologic abnormalities, including motor spinal cord and cerebellar syndromes, have rarely been described in bone marrow and liver transplant patients. " 07/01/1997 - "A woman with high-risk stage III breast cancer developed acute cerebellar syndrome 75 days after high-dose chemotherapy and blood cell transplant (BCT). " 04/01/1994 - "A 28-year-old woman with prior neurosurgery involving the placement of a cadaveric dural graft developed a rapidly progressive neurodegenerative disorder with prominent cerebellar dysfunction that was proven at autopsy to be Creutzfeldt-Jakob disease. "
4.	Surgical Decompression 08/01/2015 - "The small- to medium-sized VS can be treated by stereotactic radiosurgery, but large VS require surgical decompression for the relief of cerebellar dysfunction and increased intracranial pressure. " 07/01/1979 - "Hematomas of 2 to 3 cm produced brainstem compression or prolonged cerebellar dysfunction, and occasionally require surgical decompression. " 01/01/1977 - "A review of the clinical and surgical findings showed that (a) pain of varying type was the most common symptom, (b) four main clinical groups could be recognized--syringomyelia, paraparesis, cerebellar syndrome and 'raised pressure' syndrome and (c) surgical decompression of the posterior fossa and upper cervical spine resulted in improvement in over 70 per cent of patients with a small incidence of post-operative complications. "
5.	Craniotomy 01/01/1983 - "After a left suboccipital craniotomy and resection of the external part of the cerebellar hemisphere, the state of the patient improved quickly, and he was discharged from hospital with a light cerebellar syndrome." 05/01/1984 - "Computed tomography and findings during a suboccipital craniotomy demonstrated a mild Chiari malformation, type 1. Episodic downbeat nystagmus that is not associated with other ocular motor abnormalities due to cerebellar dysfunction can be an initial sign of a Chiari malformation."