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Cephradine (Cefradine)

A semi-synthetic cephalosporin antibiotic.

Also Known As:

Cefradine; Anspor; Nicef; Velosef; Alpharma Brand of Cephradine; Bouchara Brand of Cephradine; Bristol-Myers Squibb Brand of Cefradine; Cephradine Dihydrate; Cephradine, Non-Stoichiometric Hydrate; Dexef; Dexo Brand of Cephradine; Galen Brand of Cephradine; Kelsef; Maxisporin; Reig Jofre Brand of Cephradine; SQ-11436; Sefril; Septa Brand of Cephradine; Septacef; Squibb Brand of Cephradine; Velocef; Yamanouchi Brand of Cephradine; Zeefra Gé; Cephradine, Non Stoichiometric Hydrate; Dihydrate, Cephradine; Non-Stoichiometric Hydrate Cephradine; SQ 11436; SQ11436; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((amino-1,4-cyclohexadien-1-ylacetyl)amino)-3-methyl-8-oxo-, (6R-(6alpha,7beta(R*)))-

Networked: 126 relevant articles (13 outcomes, 19 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Jahanfar, Shayesteh: 2 articles (01/2013 - 01/2009)
2.	Teng, Cheong Lieng: 2 articles (01/2013 - 01/2009)
3.	Elhariri, M: 1 article (12/2013)
4.	Osman, K M: 1 article (12/2013)
5.	Ng, Chirk Jenn: 1 article (01/2013)
6.	Pei, Sung-Nan: 1 article (10/2010)
7.	Wu, Men-Tai: 1 article (10/2010)
8.	Chen, Guanquan: 1 article (07/2009)
9.	Jiang, Jing: 1 article (07/2009)
10.	Li, Chanjuan: 1 article (07/2009)

Related Diseases

1.	Infection 01/01/1980 - "The same dose of cephradine administered 4-times a day eradicated 64% of the infections. " 08/01/1988 - "Urine specimens taken on the fifth post-operative day showed a significantly lower urinary infection rate in those patients receiving cephradine prophylaxis." 01/01/1987 - "Recurrent urinary infections in women: clinical trial of cephradine as a prophylactic agent." 11/01/1986 - "Clinical infections were treated effectively with cephradine in more than 95% of cases. " 03/01/1980 - "Twice daily treatment with cephradine of infections in children."
2.	Wound Infection (Wound Infections) 11/01/1983 - "The effect of cephradine prophylaxis on wound infection after arterial surgery through a groin incision." 11/01/1983 - "Cephradine administered prophylactically to a group of 35 patients undergoing reversed saphenous vein femoro-popliteal bypass, iliofemoral endarterectomy or profundaplasty through a groin incision, resulted in a significant reduction in the incidence of wound infection (P = 0.025; exact probability test). " 03/01/1982 - "A short-course, low-dose perioperative prophylactic regimen of cephradine was found to be highly effective in preventing serious postoperative infections (wound, vaginal cuff/pelvic and endometrial) in patients undergoing cesarean sections and vaginal hysterectomies. " 04/01/1991 - "The incidence of purulent wound infection was low in both groups (ceftizoxime 1/99; cephradine 2/92). " 03/01/1999 - "It is concluded from this two-centre study that a single dose of teicoplanin shows similar efficacy to a three-dose regimen of cephradine plus metronidazole as prophylaxis for wound infection in vascular surgery. "
3.	Abscess 10/01/2003 - "One gram of cephradine was injected into 29 abscesses measuring more than 25 mm. Six patients refused further treatment after failure of the first aspiration and elected surgical drainage. " 01/01/1985 - "We conclude that cephradine did not alter the outcome of cutaneous abscesses at one week after incision and drainage. " 05/22/1993 - "A comparative double blind trial was undertaken of the efficacy of cephradine, amoxycillin and phenoxymethylpenicillin in the treatment of acute dentoalveolar abscesses. " 01/01/2013 - "One small trial (n = 25) compared amoxicillin with cephradine and found no significant difference between the two antibiotics in terms of symptom relief and abscess formation. " 01/01/2009 - "One small trial (n = 25) compared amoxicillin with cephradine and found no significant difference between the two antibiotics in terms of symptom relief and abscess formation. "
4.	Peritonitis 12/01/1985 - "Altogether cephradine was given orally or intraperitoneally in 88 episodes of peritonitis as drug of first choice. " 12/01/1985 - "In a prospective randomized clinical trial 84 peritonitis episodes were treated with cephradine, either orally or intraperitoneally. " 12/01/1985 - "CAPD peritonitis: a prospective randomized trial of oral versus intraperitoneal treatment with cephradine." 12/01/1985 - "We conclude that oral cephradine can be used as drug of first choice in the initial treatment of CAPD peritonitis, because a good initial response was obtained in 66 (52 + 14) i.e. " 05/01/1985 - "The results suggest that out-patient treatment with oral cephradine is an efficient way of treating CAPD peritonitis."
5.	Pneumococcal Pneumonia 02/01/1988 - "Evaluation of roxithromycin (RU-965) versus cephradine in pneumococcal pneumonia." 02/01/1988 - "One hundred and sixty black South African gold miners with acute pneumococcal pneumonia were enrolled in a prospective randomized double-blind trial comparing roxithromycin (150 mg 2 X day) with cephradine (1.0 g 2 X day). " 11/01/1987 - "A large double-blind trial comparing cephradine and roxithromycin in 90 cases of bacteriologically confirmed pneumococcal pneumonia in South African gold miners resulted in a 93% and 100% respective clinical response rate. " 11/01/1987 - "Roxithromycin appears to be a safe and effective oral antibiotic for the treatment of pneumococcal pneumonia and other infections of the lower respiratory tract, and is as effective as erythromycin, doxycycline or cephradine."

Related Drugs and Biologics

1.	Amoxicillin (Wymox)
2.	Roxithromycin
3.	Cephalexin (Cefalexin)
4.	Cefadroxil (Duricef)
5.	Penicillin V (Phenoxymethylpenicillin)
6.	Ceftriaxone (Ceftriaxon)
7.	Cefuroxime (Zinacef)
8.	Erythromycin (Erycette)
9.	Doxycycline (Vibramycin)
10.	Cefamandole

Related Therapies and Procedures

1.	Continuous Ambulatory Peritoneal Dialysis (CAPD)
2.	Vaginal Hysterectomy
3.	Endarterectomy (Thromboendarterectomy)
4.	Cesarean Section (Caesarean Section)
5.	Antibiotic Prophylaxis