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Cephapirin (Cefapirin)

Cephalosporin antibiotic, partly plasma-bound, that is effective against gram-negative and gram-positive organisms.

Also Known As:

Cefapirin; Cefadyl; Apothecon Brand of Cephapirin Sodium; BL-P 1322; Brisfirina; Bristol-Myers Brand of Cephapirin Sodium; Bristol-Myers Squibb Brand of Cephapirin Sodium; Cephapirin Monosodium Salt; Cephapirin Sodium; Céfaloject; Sodium Cephapirin; BL P 1322; BLP 1322; Cephapirin, Sodium; Monosodium Salt, Cephapirin; Salt, Cephapirin Monosodium; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-((acetyloxy)methyl)-8-oxo-7-(((4-pyridinylthio)acetyl)amino)-, (6R-trans)-

Networked: 80 relevant articles (5 outcomes, 10 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Ruegg, P L: 5 articles (09/2014 - 01/2007)
2.	Leslie, K: 3 articles (09/2011 - 06/2009)
3.	Bey, R: 3 articles (09/2011 - 06/2009)
4.	Lago, A: 3 articles (09/2011 - 06/2009)
5.	Godden, S M: 2 articles (09/2011 - 09/2011)
6.	Malmo, J: 2 articles (09/2009 - 07/2008)
7.	Anderson, G A: 2 articles (09/2009 - 07/2008)
8.	Runciman, D J: 2 articles (09/2009 - 07/2008)
9.	Johnson, W H: 2 articles (02/2005 - 09/2002)
10.	Walton, J S: 2 articles (02/2005 - 09/2002)

Related Diseases

1.	Mastitis 10/01/1991 - "Efficacy of a cephapirin dry cow product for treatment of experimentally induced Staphylococcus aureus mastitis in heifers." 06/01/2009 - "The objective of this study was to determine if an association existed between results of antimicrobial susceptibility tests and outcomes of mastitis caused by gram-positive pathogens recovered from quarters that received treatment with cephapirin sodium. " 07/01/2013 - "Extended therapy for 8 d provided milk cephapirin concentrations above the minimum inhibitory concentration for common gram-positive mastitis pathogens (0.1 to 1.0 µg/mL) for the duration of therapy and for an additional 16 to 32 h after the end of treatment. " 11/09/2012 - "aureus mastitis whereas the MIC data indicate that cefalonium and cefapirin were more active in vitro. " 06/01/2009 - "Bacteriological outcomes of mastitis treated using cephapirin were not associated with in vitro susceptibility test results or in vitro minimum inhibitory concentration values. "
2.	Endometritis 07/01/2012 - "In the present study, a commercial formosulphatiazole preparation was as effective as cephapirin and more effective than placebo for the treatment of clinical endometritis." 07/01/2012 - "The aim of this study was to compare the clinical and bacteriologic recovery following a single intrauterine administration of formosulphatiazole, cephapirin or placebo in cows with clinical endometritis. " 07/01/2008 - "To determine the effect of intrauterine cephapirin (0.5 g) treatment on the reproductive performance of cows diagnosed as at risk of developing endometritis. " 07/01/2008 - "Effect of intrauterine treatment with cephapirin on the reproductive performance of seasonally calving dairy cows at risk of endometritis following periparturient disease." 09/01/2002 - "Between 27 and 33 DIM, cows with endometritis treated with cephapirin i.u. "
3.	Infection 05/01/2014 - "The intramammary administration of sodium cephapirin at 275 mg/quarter, twice every 12 hours in lactating cows resulted in higher drug concentrations in milk of quarters with no infection than in the subclinically infected ones. " 09/01/2011 - "Quarters in the culture-based treatment program that had gram-positive growth or a mixed infection were treated according to label instruction using intramammary cephapirin sodium. " 09/01/2011 - "Quarters assigned to the culture-based treatment program were cultured on-farm and treated with cephapirin sodium after 18 to 24h of incubation if they had gram-positive growth or a mixed infection. " 04/01/1994 - "Prepartum antibiotic therapy with a cephapirin dry-cow product against naturally occurring intramammary infections in heifers." 03/01/1989 - "However, cephapirin did not eliminate the infection in any of the chambers. "
4.	Anovulation 10/01/2015 - "Overall, an intrauterine infusion of cephapirin improved first-service pregnancy risk in cows with postpartum reproductive tract disease and this effect was influenced by postpartum anovulation status. " 10/01/2015 - "The objectives of this study were to quantify the effect of an intrauterine infusion of cephapirin on reproductive performance at first service of postpartum dairy cows affected by purulent vaginal discharge (PVD) and cytological endometritis (ENDO) using different diagnostic strategies, and to determine if the presence of prolonged anovulation would influence the magnitude of treatment benefit. "
5.	Soft Tissue Infections 03/01/1989 - "Characterization of a soft-tissue infection model in the horse and its response to intravenous cephapirin administration." 04/01/1972 - "Cephapirin was effective in the treatment of 27 of 32 patients with pulmonary infection, as well as in 6 of 7 patients with staphylococcal or streptococcal soft tissue infection. "

Related Drugs and Biologics

1.	Cloprostenol
2.	benzathine
3.	Oxytetracycline (Terramycin)
4.	Cephalothin (Cefalotin)
5.	Ampicillin (Omnipen)
6.	ceforanide
7.	Methicillin (Metin)
8.	Carbon Monoxide
9.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
10.	ceftiofur

Related Therapies and Procedures

1.	Chemoprevention
2.	Renal Dialysis (Hemodialysis)
3.	Drug Therapy (Chemotherapy)
4.	Therapeutics
5.	Gynecologic Surgical Procedures (Gynecologic Surgery)