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Cephalexin (Cefalexin)

A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of CEPHALORIDINE or CEPHALOTHIN, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms.

Also Known As:

Cefalexin; Cephalexin Dihydride; Cephalexin Hemihydrate; Cephalexin Hydrochloride; Cephalexin Monohydrate; Cephalexin Monohydrochloride; Cephalexin Monohydrochloride, Monohydrate; Cephalexin, (6R-(6alpha,7alpha(R*)))-Isomer; Cephalexin, (6R-(6alpha,7beta(S*)))-Isomer; Cephalexin, (6R-(6alpha,7beta))-Isomer; Cephalexin, Monosodium Salt; Cephalexin, Monosodium Salt, (6R-(6alpha,7beta))-Isomer; Ceporexine; Palitrex; Dihydride, Cephalexin; Hemihydrate, Cephalexin; Hydrochloride, Cephalexin; Monohydrate Cephalexin Monohydrochloride; Monohydrate, Cephalexin; Monohydrochloride, Cephalexin; Monohydrochloride, Monohydrate Cephalexin; Monosodium Salt Cephalexin; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((aminophenylacetyl)amino)-3-methyl-8-oxo-, (6R-(6alpha,7beta(R*)))-

Networked: 539 relevant articles (69 outcomes, 83 trials/studies)

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Drug Context: Research Results

Experts

1.	Goby, L: 3 articles (06/2012 - 12/2009)
2.	Pichichero, Michael E: 3 articles (03/2007 - 02/2006)
3.	Miller, Loren G: 2 articles (03/2015 - 06/2012)
4.	Daum, Robert S: 2 articles (03/2015 - 06/2012)
5.	David, Michael Z: 2 articles (03/2015 - 06/2012)
6.	Taylor, Alexis R: 2 articles (03/2015 - 06/2012)
7.	Eells, Samantha J: 2 articles (03/2015 - 06/2012)
8.	Cruz, Denise: 2 articles (03/2015 - 06/2012)
9.	Kumar, Neha: 2 articles (03/2015 - 06/2012)
10.	Boyle-Vavra, Susan: 2 articles (03/2015 - 06/2012)

Related Diseases

1.	Infection 08/01/1991 - "However, by recommending a 1-day strategy of oral cephalexin only to those dental patients at high risk for late prosthetic joint infections rather than a 3-day regimen to all patients, the cost effectiveness improved from $1.1 million/QALY to $446,100/QALY while maintaining a low risk of death (0.38 deaths per 10(6) dental visits)." 03/01/1982 - "Cephalexin appeared to be equally effective in treatment of both ACB-positive and ACB-negative infections. " 01/01/2005 - "Fixation problems included two pin-track infections cleared with oral cephalexin and one broken half-pin. " 03/01/1986 - "Those patients with infections caused by cephalexin-susceptible organisms were cured at a rate similar to that for patients with infections caused by cephalexin-resistant organisms (68 versus 50%; P = 0.62). " 04/01/1981 - "The efficacy of cephalexin administered twice a day was compared to the same drug administered four times a day for the treatment of skin and skin structure infections due to staphylococcus and/or streptococcus. "
2.	Urinary Tract Infections (Urinary Tract Infection) 11/01/1989 - "Postcoital oral cephalexin prophylaxis is highly effective in the prevention of recurrent urinary tract infection in the nonpregnant as well as pregnant premenopausal women because of easy compliance, the high urine concentration achieved and the minimal induction of resistance to cephalexin in the introital gram-negative bacterial flora. " 03/01/1986 - "The efficacy of single-dose therapy with 3 g of cephalexin was evaluated in 129 women with symptoms of acute uncomplicated lower urinary tract infections. " 01/01/1983 - "Cephalexin is essentially nontoxic at recommended doses, and its clinical efficacy in urinary tract infections has been repeatedly documented in numerous studies since 1971." 03/20/1973 - "[Clinical and bacteriological studies on the course of 31 cases of most severe chronic urinary tract infections during mainly discordant cephalexin medication]." 01/01/1999 - "Synergistic bactericidal effect of cephalexin and normal cord serum (NCS) against Escherichia coli K1 strains isolated from children with urinary tract infections (UTI)."
3.	Pyoderma 08/01/2008 - "Once-daily cephalexin is as effective as twice-daily cephalexin in the treatment of canine superficial pyoderma." 12/01/2010 - "The second study was an open trial of 2CA monotherapy in eight dogs with cefalexin-resistant Staphylococcus intermedius group-associated superficial pyoderma. " 08/01/2008 - "The aims of this study were to evaluate the efficacy and tolerability of oral cephalexin given at 30 mg/kg once daily in dogs with superficial pyoderma and to compare them with those of oral cephalexin given at 15 mg/kg twice daily. " 08/01/2008 - "Efficacy and tolerability of once-daily cephalexin in canine superficial pyoderma: an open controlled study." 08/05/2011 - "Cephalexin is a first generation cephalosporin commonly used in dogs for treatment of pyoderma. "
4.	Wounds and Injuries (Trauma) 03/01/1985 - "coli and Klebsiella isolated from surgical wound regions, and the antibacterial activities were stronger than those of cephalexin (CEX). " 12/01/1998 - "Mupirocin cream applied topically 3 times daily is as effective as oral cephalexin given 4 times daily for the treatment of secondarily infected wounds and was well tolerated." 12/01/1998 - "Mupirocin cream is as effective as oral cephalexin in the treatment of secondarily infected wounds." 11/01/1988 - "Efficacy of perioperative cefamandole with postoperative cephalexin in the primary outpatient treatment of open wounds of the hand." 01/01/2012 - "Our study showed that 2-day prophylactic antibiotic therapy using Cephalexin is at least as effective as a 5-day regimen in relation to development of surgical site infection in patients with simple traumatic contaminated wounds or lacerations."
5.	Pharyngitis (Sore Throat) 06/01/1984 - "In this study, four investigators collaborated in a double-blind, randomized multicenter study assessing the efficacy of cephalexin given in doses of 1.0 g or 0.5 g daily on a bid or qid regimen for 10 to 14 days to 157 patients with GAS pharyngitis. " 06/01/1984 - "Comparison between cephalexin two- and four-time per day regimens in group A streptococcal pharyngitis." 06/01/1972 - "Cephalexin: treatment of streptococcal pharyngitis." 11/01/1977 - "Clinical study of sustained release cephalexin (S-6435 and S-6436) was conducted with the following results: 1) Pediatric patients with 1.5 approximately 12 years of age having acute tonsillitis and pharyngitis were orally administered 500 approximately 1,000 mg/day of S-6435 or S-6436 divided into 2 doses after breakfast and dinner. " 11/01/1977 - "[Clinical study of sustained release cephalexin (S-6435 and S-6436) in tonsillitis and pharyngitis (author's transl)]."

Related Drugs and Biologics

1.	Ampicillin (Omnipen)
2.	Cefadroxil (Duricef)
3.	retapamulin
4.	Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)
5.	Amoxicillin (Wymox)
6.	Trimethoprim (Proloprim)
7.	Cephalothin (Cefalotin)
8.	Cefaclor (Ceclor)
9.	Vancomycin
10.	Penicillins (Penicillin)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Antibiotic Prophylaxis
3.	Microspheres (Microsphere)
4.	Oral Administration
5.	Continuous Ambulatory Peritoneal Dialysis (CAPD)