Cementoma

An odontogenic fibroma in which cells have developed into cementoblasts and which consists largely of cementum.

Also Known As:

Cementifying Fibroma of Mandible; Cementifying Fibroma of Maxilla; Cemento-Ossifying Fibroma; Mandibular Cementifying Fibroma; Maxillary Cementifying Fibroma; Ossifying Fibroma of Mandible; Ossifying Fibroma of Maxilla; Periapical Fibrous Dysplasia; Cementifying Fibroma, Mandibular; Cementifying Fibroma, Maxillary; Cementifying Fibromas, Mandibular; Cementifying Fibromas, Maxillary; Cemento Ossifying Fibroma; Cemento-Ossifying Fibromas; Cementomas; Dysplasia, Periapical Fibrous; Fibroma, Cemento-Ossifying; Fibroma, Mandibular Cementifying; Fibroma, Maxillary Cementifying; Fibrous Dysplasia, Periapical; Fibrous Dysplasias, Periapical; Mandible Cementifying Fibroma; Mandible Cementifying Fibromas; Mandible Ossifying Fibroma; Mandible Ossifying Fibromas; Mandibular Cementifying Fibromas; Maxilla Cementifying Fibroma; Maxilla Cementifying Fibromas; Maxilla Ossifying Fibroma; Maxilla Ossifying Fibromas; Maxillary Cementifying Fibromas; Periapical Fibrous Dysplasias

Networked: 18 relevant articles (0 outcomes, 3 trials/studies)

Disease Context: Research Results

Neoplasms: 1324753
- Neoplasms by Histologic Type: 2
  - Odontogenic Tumors: 398
    - Cementoma: 18
      - Familial Gigantiform Cementoma: 4

Related Diseases

1.	Carcinogenesis
2.	Fibroma (Fibromatosis)
3.	Ossifying Fibroma
4.	Cementoma
5.	Bacterial Meningitis

Experts

1.	Diniz, Marina Gonçalves: 3 articles (04/2022 - 01/2018)
2.	Gomes, Carolina Cavaliéri: 3 articles (04/2022 - 01/2018)
3.	Gomez, Ricardo Santiago: 3 articles (04/2022 - 01/2018)
4.	Pereira, Thaís Dos Santos Fontes: 2 articles (01/2018 - 01/2018)
5.	Balaji, P: 2 articles (04/2003 - 01/2003)
6.	Patil, K: 2 articles (04/2003 - 01/2003)
7.	Du, Jintao: 1 article (01/2023)
8.	Jiang, Zihan: 1 article (01/2023)
9.	Meng, Juan: 1 article (01/2023)
10.	Wang, Yang: 1 article (01/2023)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cementoma:

1.	Proteins (Proteins, Gene)FDA Link 04/01/2022 - "Quantitative proteomic study reveals differential expression of matricellular proteins between fibrous dysplasia and cemento-ossifying fibroma pathogenesis." 07/01/2019 - "We can conclude that the nature of mineralized structure and the cellular phenotype are much more responsible for variability in immunohistochemical profile than the type of lesion (fibrous dysplasias, cemento-ossifying fibromas and cemento-osseous dysplasias) which makes difficult, at least for a while, the use of these proteins with diagnosis purpose." 07/01/2019 - "Can non-collagenous proteins be employed for the differential diagnosis among fibrous dysplasia, cemento-osseous dysplasia and cemento-ossifying fibroma?" 07/01/2019 - "The objective of this study was to investigate, comparatively, the immunohistochemical expression of major non-collagenous proteins (osteonectin [ON], osteopontin [OP], bone sialoprotein [BSP] and osteocalcin [OC]) of mineralized tissue extracellular matrix in 22 cases of fibrous dysplasias, 16 of cemento-ossifying fibromas and 16 of cemento-osseous dysplasias. "
2.	OsteopontinIBA 04/01/2007 - "An immunohistochemical evaluation of BMP-2, -4, osteopontin, osteocalcin and PCNA between ossifying fibromas of the jaws and peripheral cemento-ossifying fibromas on the gingiva." 07/01/2019 - "The objective of this study was to investigate, comparatively, the immunohistochemical expression of major non-collagenous proteins (osteonectin [ON], osteopontin [OP], bone sialoprotein [BSP] and osteocalcin [OC]) of mineralized tissue extracellular matrix in 22 cases of fibrous dysplasias, 16 of cemento-ossifying fibromas and 16 of cemento-osseous dysplasias. "
3.	OsteocalcinIBA 04/01/2007 - "An immunohistochemical evaluation of BMP-2, -4, osteopontin, osteocalcin and PCNA between ossifying fibromas of the jaws and peripheral cemento-ossifying fibromas on the gingiva." 07/01/2019 - "The objective of this study was to investigate, comparatively, the immunohistochemical expression of major non-collagenous proteins (osteonectin [ON], osteopontin [OP], bone sialoprotein [BSP] and osteocalcin [OC]) of mineralized tissue extracellular matrix in 22 cases of fibrous dysplasias, 16 of cemento-ossifying fibromas and 16 of cemento-osseous dysplasias. "
4.	Integrin-Binding SialoproteinIBA 07/01/2019 - "The objective of this study was to investigate, comparatively, the immunohistochemical expression of major non-collagenous proteins (osteonectin [ON], osteopontin [OP], bone sialoprotein [BSP] and osteocalcin [OC]) of mineralized tissue extracellular matrix in 22 cases of fibrous dysplasias, 16 of cemento-ossifying fibromas and 16 of cemento-osseous dysplasias. "
5.	Notch ReceptorsIBA 03/01/2010 - "The aim of this study was to evaluate the roles of Notch signaling in the oncogenesis and cytodifferentiation of cemento-ossifying fibroma, the expressions of Notch receptors and ligands were detected in COF and normal jaw bones. "
6.	OsteonectinIBA 07/01/2019 - "The objective of this study was to investigate, comparatively, the immunohistochemical expression of major non-collagenous proteins (osteonectin [ON], osteopontin [OP], bone sialoprotein [BSP] and osteocalcin [OC]) of mineralized tissue extracellular matrix in 22 cases of fibrous dysplasias, 16 of cemento-ossifying fibromas and 16 of cemento-osseous dysplasias. "
7.	LigandsIBA 03/01/2010 - "The aim of this study was to evaluate the roles of Notch signaling in the oncogenesis and cytodifferentiation of cemento-ossifying fibroma, the expressions of Notch receptors and ligands were detected in COF and normal jaw bones. "
8.	CateninsIBA 01/01/2018 - "The Wnt/β-catenin pathway is deregulated in cemento-ossifying fibromas."
9.	MicroRNAs (MicroRNA)IBA 01/01/2018 - "MicroRNA profiling reveals dysregulated microRNAs and their target gene regulatory networks in cemento-ossifying fibroma."
10.	Proliferating Cell Nuclear Antigen (PCNA)IBA 04/01/2007 - "An immunohistochemical evaluation of BMP-2, -4, osteopontin, osteocalcin and PCNA between ossifying fibromas of the jaws and peripheral cemento-ossifying fibromas on the gingiva."

Therapies and Procedures

1.	Oral Medicine 04/01/2003 - "A case of Juvenile Aggressive Cemento-Ossifying Fibroma in a 9 year old male child who visited the Department of Oral Medicine and Radiology, J.S.S. " 01/01/2003 - "A case of Juvenile Aggressive Cemento-Ossifying Fibroma in a 9 year old male child who visited the Department of Oral Medicine and Radiology, J.S.S. "
2.	Conservative Treatment 01/01/2022 - "Cystic degeneration in cemento-ossifying fibroma: Diagnosis challenge and conservative management - Case report." 01/01/2017 - "Conservative Management of Central Cemento-Ossifying Fibroma."
3.	Mandibular Osteotomy 12/19/2021 - "In this report, we describe a case of cemento-ossifying fibroma in a female patient who underwent segmental mandibulectomy and reconstruction with an iliac bone graft. "
4.	Prostheses and Implants (Prosthesis) 08/27/2023 - "A 39-year-old woman who had undergone fibular flap reconstruction and simultaneous implant placement after the surgical removal of a cemento-ossifying fibroma was experiencing mild discomfort 3 years later and requested an implant-supported prosthesis to restore her edentulous left maxillary quadrant. "
5.	Therapeutics 08/01/1984 - "This mode of therapy for the benign cementoblastoma should not be confused with the entity called periapical cemental dysplasia (that is cementoma, periapical osteofibroma or osteofibrosis, cementifying fibroma, localized fibro-osteoma, and periapical fibrous dysplasia). "