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Celiac Disease (Celiac Sprue)

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A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.

Also Known As:

Celiac Sprue; Nontropical Sprue; Gluten-Sensitive Enteropathy; Disease, Celiac; Enteropathies, Gluten; Enteropathies, Gluten-Sensitive; Enteropathy, Gluten; Enteropathy, Gluten-Sensitive; Gluten Enteropathies; Gluten Sensitive Enteropathy; Gluten-Sensitive Enteropathies; Gluten Enteropathy; Sprue, Celiac; Sprue, Nontropical

Networked: 4175 relevant articles (117 outcomes, 370 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Dermatitis Herpetiformis (Disease, Duhring's)
2.	Atrophy
3.	Celiac Disease (Celiac Sprue)
4.	Crohn Disease (Crohn's Disease)
5.	Neoplasms (Cancer)

Experts

1.	Sollid, Ludvig M: 71 articles (12/2015 - 09/2002)
2.	Kaukinen, Katri: 61 articles (11/2015 - 03/2002)
3.	Murray, Joseph A: 58 articles (12/2015 - 05/2002)
4.	Mäki, Markku: 57 articles (11/2015 - 01/2002)
5.	Khosla, Chaitan: 51 articles (08/2014 - 01/2002)
6.	Fasano, Alessio: 46 articles (09/2015 - 06/2002)
7.	Koning, Frits: 46 articles (06/2015 - 03/2002)
8.	Green, Peter H R: 42 articles (09/2015 - 06/2002)
9.	Troncone, Riccardo: 42 articles (09/2015 - 03/2003)
10.	Collin, Pekka: 36 articles (12/2014 - 03/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Celiac Disease:

1.	Glutens (Glutelin)IBA 01/01/2015 - "This is important in development of celiac disease (CD) but may also be important in type 1 diabetes (T1D), and could potentially explain the reduced incidence of T1D in mice receiving a gluten-free (GF) diet. " 04/01/2008 - "Clinical, serological and histological remission in celiac disease is strictly related to long life complete exclusion of gluten from the diet. " 04/01/2005 - "Complete removal of gluten from the diet in a patient with celiac disease should result in symptomatic, serologic, and histologic remission. " 02/01/2012 - "In these culture systems, gluten induces different effects that can be quantified, thus also enabling studies concerning the efficacy of candidate therapeutic compounds for celiac disease. " 06/01/2015 - "The nutritional value of gluten-free products is the subject of interest for food technologists and nutritionists, as the only effective treatment for celiac disease is a lifelong gluten-free diet. "
2.	AntibodiesIBA 09/01/2007 - "These antibodies, primarily to tissue transglutaminase, are the basis for highly accurate serologic testing, although the gold standard for celiac disease diagnosis remains small intestinal biopsy. " 01/01/1999 - "Anti-endomysial antibodies (EmA) have been shown to have a high specificity and sensitivity in celiac disease (CD) diagnosis, and their use is considered effective in improving the diagnostic accuracy of CD screening. " 09/01/2012 - "As a third of patients remained undiagnosed, in spite of genetic study and specific coeliac serology, flow cytometry and transglutaminase antibodies in duodenal tissue may be helpful in establishing gluten-sensitive enteropathy diagnosis. " 03/01/2014 - "Anti-tissue transglutaminase and anti-endomysial antibodies may help to identify those individuals in whom intestinal biopsy is indicated for the diagnosis of celiac disease. " 12/01/2013 - "Anti-tissue transglutaminase antibodies (ATTG) have helped to distinguish atypical and silent clinical forms of celiac disease (CD). "
3.	Immunoglobulin A (IgA)IBA 09/01/2002 - "screening for celiac disease using IgA EmA assay is effective in anemic patients, including premenopausal women and patients older than 65 years, and it can be recommended in clinical practice." 01/01/2010 - "Histology is still necessary to diagnose celiac disease and IgA-AAA cannot be included in usual screening tests, because it has little to offer if compared to the well-established tTG-Ab.IgA-AAA could be an adjunctive, very useful tool to support the diagnosis of CD in case of suboptimal histology, when the biopsy is to be avoided for clinical reasons, or in case of negative parents' consensus." 01/01/1994 - "Childhood celiac disease in Estonia: efficacy of the IgA-class antigliadin antibody test in the search for new cases." 11/01/1998 - "Improved method for serological testing in celiac disease--IgA anti-endomysium antibody test: a comparison between monkey oesophagus and human umbilical cord as substrate in indirect immunofluorescence test." 03/01/1975 - "In contrast to patients with gluten-sensitive enteropathy in remission (i.e., on a gluten-free diet), jejunal IgA synthesis did not decline. "
4.	GliadinIBA 04/01/2008 - "Deamidated gliadin antibody is a better diagnostic test for celiac disease than the conventional gliadin antibody testing; although histopathology remains the gold standard test for diagnosis of celiac patients." 10/14/2015 - "Kuma030 is capable of degrading >99% of the immunogenic gliadin fraction in laboratory-simulated gastric digestions within physiologically relevant time frames, to a level below the toxic threshold for celiac patients, suggesting great potential for this enzyme as an oral therapeutic for celiac disease. " 11/11/1990 - "According to these results the authors conclude that the efficacy of this test is less sensitive in the newly diagnosed celiac patients, which means that it is not suitable for screening purpose, but useful for detecting gliadin sensitivity during the diagnostic period of celiac disease (e. " 08/01/2011 - "In addition, the recently developed deamidated gliadin peptide antibody tests show promise in celiac disease diagnostics. " 06/01/2015 - "In the present study, we explored this strategy as a means of modulating the immune response to wheat gliadin, the triggering agent of celiac disease (CD), an enteropathy driven by inflammatory CD4(+) T cells. "
5.	Immunoglobulin G (IgG)IBA 11/01/2015 - "The discrepancy in levels of IgAG-DGP/tTG and IgG-tTG between Swedish and Danish T1D cohorts was independent of HLA and suggests that regional variations in comorbidity of celiac disease in T1D is caused by difference in exposure to environmental factors." 01/01/2015 - "Celiac disease patient sera or total IgG was injected into athymic mice. " 01/01/2015 - "The experimentally induced condition in the mice injected with patient serum or IgG resembles early developing celiac disease in humans. " 01/01/2015 - "The mice injected with celiac patient sera or IgG had significantly decreased villus height crypt depth (Vh/CrD) ratios and celiac disease-specific autoantibody deposits targeted to TG2 in several tissues, including the small intestine. " 01/01/2013 - "Celiac disease sera harbor a higher antiprothrombin immunoglobulin G level compared with controls. "
6.	PeptidesIBA 03/01/2003 - "DON-modified peptides could be useful for the study and therapy of celiac sprue." 10/01/2000 - "However, further studies with optimized methodology, including various concentrations of the peptide, adjuvants, other peptides, etc., are warranted, especially because the oral mucosa provides the easiest access to an in vivo peptide challenge in celiac disease." 03/01/1959 - "[Studies on appearance of serum peptides in celiac disease]." 11/01/2015 - "T cells from the children recognized the same peptides that were immunogenic to adults with celiac disease; deamidation of peptides increased these responses. " 04/01/2015 - "In susceptible individuals, the deamidated peptides initiate an immune response leading to celiac disease. "
7.	AntigensIBA 12/01/2000 - "Over the past few years, the availability, sensitivity and specificity of serological markers for celiac disease have improved - the most recent advancement being the description of tissue transglutaminase as the major antigen for endomysium antibody. " 03/01/2011 - "As our understanding of celiac disease increases with further isolation of nonhuman leukocyte antigen genes and clarification of the intracellular pathways that underlie its pathogenesis, there are new modalities which will not only allow improved risk stratification of individuals but also facilitate the development of novel therapeutic agents. " 07/01/2015 - "Systematic review of published studies assessing accuracy of human leukocyte antigen DQ2 and DQ8 typing for the detection of celiac disease were selected. " 04/01/2014 - "The aim of this study is to determine the prevalence of celiac disease in a group of first degree relatives of celiac children, and to access the frequency of human leukocyte antigen HLA-DQ2 and DQ8 in celiac disease patients and their affected relatives. " 11/01/2008 - "The aim of this study was to assess the distribution of human leukocyte antigen (HLA) groups in Turkish children with celiac disease (CD) and to investigate the association of HLA types and clinical manifestations of CD. "
8.	AutoantibodiesIBA 12/01/2011 - "The aim was to study the efficacy of the pTnT-rhtTG plasmid and subsequent diagnostic accuracy of tTG autoantibodies for childhood celiac disease using radioligand binding assays. " 12/01/2011 - "Improved efficacy by using the pTnT-rhtTG plasmid for the detection of celiac disease specific tissue transglutaminase autoantibodies in radioligand binding assays." 09/01/2008 - "To investigate if the detection of celiac disease (CD) in children was improved by using alternative conjugates for assessment of tissue transglutaminase (tTG) autoantibodies. " 01/01/2015 - "The two studies of unrecognized celiac disease (elevated circulating concentrations of celiac disease-specific autoantibodies but no celiac disease diagnosis) had contradicting findings. " 07/01/2014 - "The female predominance in celiac disease is difficult to explain because population-based screening studies reveal similar rates for celiac disease-specific autoantibodies in males and females. "
9.	Immunoglobulins (Immunoglobulin)IBA 01/01/2015 - "The aim of this study was to establish whether celiac disease can be passively transferred to mice by serum or immunoglobulins. " 09/01/2015 - "In the present narrative review, we analyzed the relationship between seronegative celiac disease (SNCD) and immunoglobulin deficiencies. " 09/01/2015 - "Seronegative Celiac Disease and Immunoglobulin Deficiency: Where to Look in the Submerged Iceberg?" 07/01/2015 - "The degree of mucosal damage to the small intestine and serum immunoglobulin G4 levels correlate with celiac disease." 01/01/2015 - "Injection of celiac disease patient sera or immunoglobulins to mice reproduces a condition mimicking early developing celiac disease."
10.	Xylose (D-Xylose)FDA Link 11/01/2010 - "The aim of the study was to compare three different D-xylose test modalities for small intestinal malabsorption, using patients with celiac disease and healthy persons as experimental models. " 03/01/2007 - "This study indicates that performance of 5-g D-xylose H2BT is a better test than 5-g urinary D-xylose test in screening for intestinal malabsorption in patients with celiac disease." 03/01/2007 - "This study sought to compare D-xylose H2BT with urinary D-xylose tests in screening for intestinal malabsorption in patients with celiac disease. " 11/01/2010 - "The (13)C-D-xylose breath test was superior to D-xylose testing in plasma and urine for assessment of small intestinal malabsorption with considerably higher sensitivity and specificity for untreated celiac disease." 11/01/2010 - "Test sensitivity/specificity for celiac disease was 88%/84% with the (13)C-D-xylose breath test, 65%/71% with the 1-h plasma D-xylose test, and 55%/74% with the 4-h urine D-xylose excretion test. "

Therapies and Procedures

1.	Aftercare (After-Treatment) 01/01/2004 - "The children with celiac disease did not differ in any of the parameters tested when compared to those without celiac disease, though they showed an improvement in growth velocity after treatment with a gluten-free diet. " 07/01/2014 - "In patients with newly started gluten-free diet, HbA1c and BMI within a year after diagnosis of celiac disease were compared to a year period six months after treatment commencement (3-4 visits), atTG was evaluated one year after treatment beginning. " 03/01/2012 - "Doses decreased significantly after treatment of celiac disease (154 μg vs 111 μg, P=.03; and 2.64 μg/kg vs 1.89 μg/kg, P=.04). " 12/01/2011 - "Nonresponsive celiac disease (CD) is defined by persistent or recurrent symptoms, common after treatment with a gluten-free diet (GFD). " 06/01/2011 - "We prospectively estimated the performance of seven celiac disease-related antibody tests at diagnosis and at 1 year and more than 4 years after treatment initiation in 53 adults. "
2.	Jejunoileal Bypass 10/17/1997 - "The underlying causes of malabsorption were celiac disease, short bowel syndrome secondary to surgical resection, and jejuno-ileal bypass, respectively. " 08/01/2003 - "Joint involvement also occurs with other gastrointestinal diseases such as Whipple's disease, celiac disease, and following intestinal bypass surgery for morbid obesity. " 10/01/1977 - "Hyperoxaluria was documented in patients with pancreatic insufficiency, adult celiac disease, regional enteritis after ileectomy and partial colectomy, and jejunoileal bypass. " 01/01/1992 - "2. Whipple's disease, enteric infections, intestinal bypass operations, gluten-sensitive enteropathy, pseudomembranous colitis and collagenous colitis." 09/01/1981 - "IP has been associated with various disorders: in our series two patients had scleroderma, one multiple small bowel diverticula, one systemic amyloidosis, one celiac disease, and one spinal cord injury; in only two patients was the disorder considered "idiopathic." Three patients had previously undergone a jejuno--ileal bypass for morbid obesity. "
3.	Gastrectomy 01/01/1966 - "Gluten enteropathy following partial gastrectomy. " 12/01/2010 - "The odds of fracture (odds ratio (OR), 95% confidence interval (CI)) compared with controls, adjusted for age, gender, and race was: CP 2.4 (2.1, 2.9); Crohn's disease 1.7 (1.5, 2.0); gastrectomy 2.5 (1.5, 4.1); cirrhosis 2.6 (2.4, 2.7); and celiac disease 2.7 (2.1, 3.4). " 02/01/1984 - "Alcoholic cirrhosis, obstruction of the biliary tract, gastrectomy, celiac sprue and prolonged fasting may predispose to lithiasis secondary to the precipitation of sludge in a large, atonic or distended gallbladder. " 10/01/1999 - "Diseases of the alimentary tract such as celiac disease, inflammatory bowel diseases, gastrectomy, cholestatic liver diseases, liver transplantation, and hepatitis C can affect bone mineralization, remodeling, or bone mass. " 03/01/1975 - "The patient had gluten sensitive enteropathy, and showed increased circulating IgA levels prior to gastrectomy. "
4.	Gastric Bypass (Roux-en-Y Gastric Bypass) 08/01/2011 - "Pregnant women who are vegetarian or vegan, have Crohn's or celiac disease, or have undergone gastric bypass surgery are at increased risk of B12 deficiency. " 05/01/1972 - "Endoscopic appearance of the jejunum in a patient with gluten-sensitive enteropathy and a gastrojejunostomy." 04/01/2009 - "Self-reported vitamin D supplementation, milk intake, celiac disease, gastric bypass, and chronic pancreatitis were predictive of vitamin D status. " 09/01/2005 - "Ten patients were studied with chronic fat malabsorption, calcium oxalate stones, and hyperoxaluria thought to be caused by jejunoileal bypass (1) and Roux-en-Y gastric bypass surgery for obesity (4), dumping syndrome secondary to gastrectomy (2), celiac sprue (1), chronic pancreatitis (1), and ulcerative colitis in remission (1). "
5.	Endoscopes 07/01/2009 - "In evaluating patients with refractory or complicated celiac disease, in whom a complete evaluation of the small bowel is mandatory (at least in refractory celiac disease type II patients) because of the possible presence of complications beyond the reach of conventional endoscopes, both capsule endoscopy and balloon-assisted enteroscopy have been found to be helpful. " 01/01/2012 - "Endoscope distortion correction does not (easily) improve mucosa-based classification of celiac disease."