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Cefoxitin (Cefoxitin Sodium)

A semisynthetic cephamycin antibiotic resistant to beta-lactamase.

Also Known As:

Cefoxitin Sodium; Mefoxin; MK-306; MSD Brand of Cefoxitin Sodium; Mefoxitin; Merck Brand of Cefoxitin Sodium; Merck Frosst Brand of Cefoxitin Sodium; Merck Sharp & Dohme Brand of Cefoxitin Sodium; Méfoxin; MK 306; MK306; Sodium, Cefoxitin; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-7-methoxy-8-oxo-7-((2-thienylacetyl)amino)-, (6R-cis)-

Networked: 674 relevant articles (126 outcomes, 124 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Mainardi, Jean-Luc: 3 articles (04/2015 - 03/2014)
2.	Dubée, Vincent: 3 articles (04/2015 - 03/2014)
3.	Arthur, Michel: 2 articles (04/2015 - 03/2014)
4.	Gutmann, Laurent: 2 articles (04/2015 - 03/2014)
5.	Gaillard, Jean-Louis: 2 articles (04/2015 - 03/2014)
6.	Hugonnet, Jean-Emmanuel: 2 articles (04/2015 - 03/2014)
7.	Chau, Françoise: 2 articles (04/2014 - 03/2012)
8.	Fantin, Bruno: 2 articles (04/2014 - 03/2012)
9.	Lepeule, Raphaël: 2 articles (04/2014 - 03/2012)
10.	Lefort, Agnès: 2 articles (04/2014 - 03/2012)

Related Diseases

1.	Infection 01/01/1988 - "Numerous studies have shown that cefoxitin is clearly effective; in most of these studies, however, either the initial infection rates were low or the sample sizes were small--circumstances making it difficult to establish the superiority of any one agent. " 01/01/1979 - "Bacteriologic response to therapy with cefoxitin was equally good for infections due to gram-positive cocci (94% cured), gram-negative bacilli (87% cured), and anaerobes (95% cured). " 04/01/1982 - "The result of this study demonstrates that cefoxitin when given massively is effective in achieving bacteriologic and clinical cure in treatment of infections and for prevention of postoperative infections in the field of obstetrics and gynecology." 10/27/1983 - "The therapeutic efficacy of cefoxitin was studied in 15 patients with pulmonary or urinary infections, after other unsuccessful antibiotic treatment. " 03/01/1981 - "5. Among the 50 patients with various infections, cefoxitin was clinically effective in 84% and bacterial response in 87%. "
2.	Wound Infection (Wound Infections) 03/01/1981 - "The study shows that even a very short peroperative course of Cefoxitin is highly effective in reducing postoperative abdominal wound infections after elective colorectal surgery." 08/01/1982 - "A significant reduction in wound infection was evident in the cefoxitin-treated group (4.4 per cent) when compared with controls (16.7 per cent) (chi 2 = 6; P = 0.02). " 02/01/2001 - "Eleven women (4.6%) in the placebo group and eight (3.4%) in the cefoxitin group had microbiological evidence of wound infection. " 02/01/2001 - "Wound infection was the most common complication occurring in 13.3% and 12.5% of women in the placebo and cefoxitin groups, respectively. " 02/01/1994 - "Wound infection occurred in three patients, 2.4% of the cefoxitin group and in five patients (4%) of the second group (with no significant difference). "
3.	Urinary Tract Infections (Urinary Tract Infection) 05/06/1978 - "Cefoxitin was also found to be effective in lung and urinary tract infections against sensitive organisms. " 12/01/1983 - "Febrile morbidity alone tended to occur in the cefoxitin group (15.6% vs. 3.7%; p = 0.091), and all five urinary tract infections occurred in the cefoxitin group as well. " 06/05/1981 - "[Treatment of urinary tract infection with cefoxitin]." 07/01/1978 - "Cefoxitin sodium in complicated urinary tract infection." 07/01/1978 - "Intravenous cefoxitin sodium in the treatment of urinary tract infections."
4.	Pelvic Inflammatory Disease (Pelvic Inflammatory Diseases) 04/01/1988 - "This study suggests that the combination of cefoxitin and doxycycline is effective for ambulatory treatment of pelvic inflammatory disease." 10/29/1983 - "Efficacy of ampicillin and cefoxitin in the treatment of acute pelvic inflammatory disease. " 10/01/2008 - "Failure of cefoxitin and doxycycline to eradicate endometrial Mycoplasma genitalium and the consequence for clinical cure of pelvic inflammatory disease." 02/01/2008 - "genitalium has been associated with treatment failure following cefoxitin and doxycycline treatment for clinically suspected pelvic inflammatory disease. " 01/01/1997 - "Ampicillin/Sulbactam vs. Cefoxitin for the treatment of pelvic inflammatory disease."
5.	Sepsis (Septicemia) 09/01/1981 - "[Clinical studies of cefoxitin for the treatment of septicemia (author's transl)]." 02/01/2008 - "The overall sepsis rate was 19% (40/211 women) in the placebo group and 16.9% (36/213 women) in the cefoxitin group (P = .581). " 01/01/1998 - "The plasma and peritoneal fluid pharmacokinetic parameters obtained after the intravenous administration of free and liposomal cefoxitin were studied in a porcine model of intraabdominal sepsis. " 01/01/1998 - "Distribution of free and liposomal cefoxitin in plasma and peritoneal fluid in a porcine intra-abdominal sepsis model." 01/01/1996 - "The results of these experiments demonstrate that liposomal cefoxitin exerts a beneficial modulation of some of the hemodynamic disturbances during intra-abdominal Gram-negative sepsis."

Related Drugs and Biologics

1.	Clindamycin (Cleocin)
2.	Gentamicins (Gentamicin)
3.	Cefotetan (Cefotan)
4.	Anti-Bacterial Agents (Antibiotics)
5.	Metronidazole (Metric)
6.	Cefmetazole (Cefmetazole Sodium)
7.	Doxycycline (Vibramycin)
8.	Ceftizoxime (Cefizox)
9.	Moxalactam (Latamoxef)
10.	Cefotaxime (Kendrick)

Related Therapies and Procedures

1.	Hysterectomy
2.	Cesarean Section (Caesarean Section)
3.	Chemoprevention
4.	Laparotomy
5.	Anesthesia