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Cefoperazone (Cefoperazone Sodium)

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Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It has been proposed especially against Pseudomonas infections.

Also Known As:

Cefoperazone Sodium; Cefobid; Cefoperazon; Cefoperazone Sodium Salt; Céfobis; Farmasierra Brand of Cefoperazone Sodium; Pfizer Brand of Cefoperazone Sodium; T-1551; T1551; Salt, Cefoperazone Sodium; Sodium Salt, Cefoperazone; Sodium, Cefoperazone; T 1551; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((((4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl)amino)(4-hydroxyphenyl)acetyl)amino)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, (6R-(6alpha,7beta(R*)))-

Networked: 500 relevant articles (82 outcomes, 97 trials/studies)

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Drug Context: Research Results

Experts

1.	Schwarz, Stefan: 2 articles (07/2014 - 05/2012)
2.	Young, Vincent B: 2 articles (01/2013 - 01/2012)
3.	Huffnagle, Gary B: 2 articles (01/2013 - 01/2012)
4.	Liu, Jin: 2 articles (02/2011 - 01/2006)
5.	Patel, Kamlesh R: 2 articles (12/2010 - 10/2008)
6.	Kochhar, Puja: 2 articles (06/2008 - 03/2008)
7.	Apisarnthanarak, Anucha: 2 articles (04/2006 - 03/2002)
8.	Haberal, Mehmet: 2 articles (11/2005 - 09/2004)
9.	Woo, Patrick C Y: 2 articles (10/2005 - 12/2003)
10.	Lau, Susanna K P: 2 articles (10/2005 - 12/2003)

Related Diseases

1.	Infection 01/01/1984 - "Cefoperazone appears to be extremely useful in the treatment of various infections in hospitalized patients." 01/01/1981 - "In conclusion, cefoperazone was considered to be effective in treating biliary tract infections because of its broad antibacterial spectrum and high penetration into bile." 03/01/1991 - "Patients with infections due to gram-negative organisms responded well to all three agents, whereas patients with gram-positive infections responded more favorably to cefoperazone. " 11/01/1992 - "The therapeutic efficacy of liposomal cefoperazone against Pseudomonas aeruginosa was investigated in a granulocytopenic mouse model of acute lung infection. " 01/01/1981 - "Twice daily dosing with cefoperazone appears to be effective against numerous Gram-positive and Gram-negative bacteria in a variety of clinical infections."
2.	Respiratory Tract Infections (Respiratory Tract Infection) 01/01/1983 - "Cefoperazone was found to be effective in the treatment of lower respiratory tract infections." 03/01/1983 - "The results of this study indicate that cefoperazone is a safe and effective antibiotic for the treatment of lower respiratory tract infections due to S. " 01/01/1983 - "The results of this study indicate that cefoperazone is safe and effective in the therapy of acute bacterial lower respiratory tract infections." 05/01/1989 - "Clinical effectiveness of cefoperazone (CPZ) was studied for 46 elderly patients with respiratory infections. " 05/01/1989 - "[Clinical effectiveness of cefoperazone for respiratory infections of elderly patients, focusing on its safety on renal function]."
3.	Bacterial Infections (Bacterial Infection) 01/01/1986 - "These favourable properties, together with its good antibacterial activity, suggest that cefoperazone will be effective in treating bacterial infections in human beings." 01/01/1981 - "The high cefoperazone concentrations found in serum and different tissues lead us to expect successful therapy when cefoperazone is used to treat bacterial infections with sensitive pathogens in the urogenital tract." 03/01/1983 - "The results indicate that cefoperazone sodium is a safe and effective antibiotic for use in adults and children with serious bacterial infections." 04/24/1989 - "Analyzing the preliminary data form the experimental studies on the influence of Cefoperazone on mixed, viral-bacterial infections in mice we found the positive effect of the antibiotic evaluated in some immunological test. " 03/01/1983 - "Cefoperazone sodium in the treatment of serious bacterial infections in 2,100 adults and children: multicentered trials in Europe, Latin America, and Australasia."
4.	Pneumonia (Pneumonitis) 01/01/1981 - "All of these patients were infected by organisms sensitive to cefoperazone by disc testing but in 5 of those who relapsed the cefoperazone MIC was in fact greater than or equal to 50 microgram/ml. Ten of 11 cases with radiologically confirmed pneumonia were cured with cefoperazone. " 06/01/1988 - "Cefoperazone versus combination antibiotic therapy of hospital-acquired pneumonia." 01/01/1988 - "Cefoperazone is a suitable alternative to combination antibiotic therapy for the treatment of hospital-acquired pneumonia." 01/01/1988 - "Cefoperazone monotherapy was compared with combination antibiotic therapy in a randomized prospective evaluation of patients with hospital-acquired pneumonia. " 01/01/1988 - "Cefoperazone versus combination antibiotic therapy of hospital-acquired pneumonia."
5.	Neoplasms (Cancer) 03/01/1983 - "Cefoperazone was used for the treatment of 105 febrile episodes in 103 patients with cancer. " 08/01/1992 - "[Experience with using cefoperazone in cancer patients after bone marrow transplantation]." 07/25/1988 - "Previous studies have shown that cefoperazone given in frequent, large doses is effective in the treatment of infection in patients with cancer. " 03/01/1983 - "This study indicates that cefoperazone has low toxicity and is effective for the treatment of infections in patients with cancer." 07/01/1989 - "Cefoperazone is a broad-spectrum cephalosporin that has been used extensively to treat infections in cancer patients. "

Related Drugs and Biologics

1.	Sulbactam
2.	Ceftriaxone (Ceftriaxon)
3.	Cefotaxime (Kendrick)
4.	Piperacillin
5.	Ceftazidime (Fortum)
6.	Moxalactam (Latamoxef)
7.	beta-Lactamases (beta-Lactamase)
8.	Anti-Bacterial Agents (Antibiotics)
9.	Tobramycin (Nebcin)
10.	Gentamicins (Gentamicin)

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1.	Tracheostomy
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4.	Home Nursing (Nursing, Home)
5.	Choledochostomy