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Cefamandole

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Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as the nafate.

Also Known As:

Cephamandole; Compound 83405; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((hydroxyphenylacetyl)amino)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, (6R-(6alpha,7beta(R*)))-

Networked: 332 relevant articles (63 outcomes, 59 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Pichichero, Michael E: 2 articles (03/2007 - 03/2007)
2.	Ivanova, M: 1 article (08/2009)
3.	Marina, M: 1 article (08/2009)
4.	Kantardjiev, T: 1 article (08/2009)
5.	Kato, Sayaka: 1 article (06/2008)
6.	Tamai, Ikumi: 1 article (06/2008)
7.	Sai, Yoshimichi: 1 article (06/2008)
8.	Takahara, Seiko: 1 article (06/2008)
9.	Yabuuchi, Hikaru: 1 article (06/2008)
10.	Kato, Yukio: 1 article (06/2008)

Related Diseases

1.	Infection 01/01/1980 - "These data suggest that cefamandole is effective in treatment of most anaerobic infections." 03/01/1979 - "These data suggest that cefamandole is effective in treatment of most anaerobic infections." 01/01/1983 - "These data suggest that cefamandole is an effective agent for the initial treatment of nonmeningitic infections in children." 07/01/1981 - "Pharmacology, Safety, and efficacy of cefamandole in childhood infections." 01/01/1980 - "The safety and efficacy of treatment with cefamandole were evaluated in 77 patients (from 33 institutions) with serious bone and joint infections. "
2.	Sepsis (Septicemia) 08/01/1984 - "Overall, cefamandole showed superior coverage in vitro against the biliary flora, but both drugs were equally effective in maintaining a low incidence of postoperative sepsis as well as a minimal number of febrile or total hospital days. " 04/01/1984 - "Preincisional cefamandole is effective in reducing postoperative sepsis after operations upon the gastrointestinal tract." 04/01/1984 - "A randomized prospective trial comparing the value of intravenous and preincisional cefamandole in reducing postoperative sepsis after operations upon the gastrointestinal tract." 09/01/1981 - "Bacteroides fragilis septicemia during cefamandole therapy." 06/01/1978 - "Therefore, in those patients with biliary tract sepsis, in whom a cephalosporin is indicated for therapy, cefamandole appears to be the drug of choice."
3.	Wounds and Injuries (Trauma) 10/01/1994 - "Infective wound complications were observed only in the cefamandole group. " 10/01/1989 - "In the cefamandole group, colonization rates in anterior nares and chest skin or wound were 53.3% and 60% respectively before surgery and became 53.3% and 40% respectively after surgery. " 09/01/1987 - "The most common organism isolated from infected wounds with cefamandole was Staphylococcus aureus followed by S. " 11/01/1986 - "A postoperative dose of cefamandole 2 g iv q6h will provide sustained and therapeutic concentrations in the wound drainage of morbidly obese patients." 11/01/1986 - "Cefamandole distribution in serum, adipose tissue, and wound drainage in morbidly obese patients."
4.	Pneumonia (Pneumonitis) 01/01/1980 - "Sputum levels were 0.27 to 2.5 microgram/ml. Cefamandole appears to be an effective antibiotic for treatment of gram-negative pneumonia caused by susceptible organisms." 07/01/1985 - "Although cefamandole has been recommended in empiric therapy for patients with community-acquired pneumonia and as a prophylactic agent for patients having various surgical procedures, other regimens are less expensive and just as effective. " 01/01/1980 - "cefamandole 1 000 mg 8 h and 500 mg 8 h, were compared in the treatment of assumed community-acquired pneumonia in 59 hospitalized adult patients. " 01/01/1980 - "Clinical experience with cefamandole in pneumonia." 03/01/1980 - "In 33.3% of patients treated, cefamandole was evaluated as quite useful in the treatment of pneumonia or lung abscess. "
5.	Urinary Tract Infections (Urinary Tract Infection) 05/03/1980 - "Drug trials: treatment of urinary tract infection with multiple-dose intramuscular administration of cephamandole." 02/01/1977 - "Our studies indicate that a dosage regimen of 1 g of cefamandole every 8 h in patients with normal renal function results in urine concentrations sufficiently high for treatment of most common urinary tract infections. " 10/01/1984 - "In the intravenous cefamandole group there was only one patient who developed a urinary tract infection after operation. " 05/17/1980 - "Treatment of urinary tract infection with a single-dose intramuscular administration of cephamandole." 11/01/1979 - "The cefamandole half-life (1 1/2) on dialysis was 4.0 +/- 0.29 hr; off dialysis it was 13.9 +/- 4.2 hr. High urine concentrations of cefamandole in these patients suggests usefulness in urinary tract infection."

Related Drugs and Biologics

1.	Cefazolin (Ancef)
2.	Anti-Bacterial Agents (Antibiotics)
3.	Tobramycin (Nebcin)
4.	Cefonicid (Monocid)
5.	Gentamicins (Gentamicin)
6.	Cephalothin (Cefalotin)
7.	Cefoperazone (Cefoperazone Sodium)
8.	Clindamycin (Cleocin)
9.	Penicillins (Penicillin)
10.	Cefoxitin (Cefoxitin Sodium)

Related Therapies and Procedures

1.	Internal Fixators
2.	Hip Replacement Arthroplasty (Total Hip Replacement)
3.	Continuous Ambulatory Peritoneal Dialysis (CAPD)
4.	Appendectomy
5.	Prostheses and Implants (Prosthesis)