Monovalent Cations

12/20/2013 - "We report here pH-selective transfer of nano-pores to cancer cells for the dis-regulation of balance of monovalent cations to induce cell death at mildly acidic pHe as it is in most solid tumors. "
01/01/1989 - "The intensity of O2 adsorption by ascites tumor cells does not practically depend on the monovalent cation concentration gradient between the cells and the culture medium, whereas the rate of glycolysis decreases simultaneously with the diminution of the concentration gradient. "
01/01/1986 - "[Energy characteristics of the transport of monovalent cations in ascites tumor cells]."
03/01/1993 - "The monovalent cation lithium has been shown to be an effective agent capable of modulating several aspects of haematopoiesis such as the induction of neutrophilia, thrombopoiesis, and protection against suppression of hematopoietic progenitor stem cells following exposure to anti-cancer drugs and/or radiation at doses commonly used in the treatment of malignant disease. "
03/01/2012 - "G-quadruplexes, formed of four stranded guanine bases stabilized by monovalent cations, serve important role in cancer cell growth and control gene expression in telomere. "

01/01/1982 - "Effects of cetiedil on monovalent cation permeability in the erythrocyte: an explanation for the efficacy of cetiedil in the treatment of sickle cell anemia."

12/01/1991 - "We had previously observed that monovalent cation fluxes were elevated in hypertension. "
08/01/1987 - "[Erythrocyte membrane permeability of monovalent cations in rats with spontaneous arterial hypertension]."
08/01/1989 - "[Transport of monovalent cations and calcium in erythrocytes of rats with spontaneous hypertension: study with fractions enriched with young and old cells]."
03/01/1995 - "Insulin unresponsiveness of tubular monovalent cation transport during fructose-induced hypertension in rats."
01/01/1986 - "Erythrocyte lithium-sodium countertransport, a mode of ouabain-insensitive monovalent cation metabolism, is increased in human essential hypertension, but no pathophysiological link to hypertension has yet been established. "

06/01/1985 - "Addition of haemolytic Sendai virus or Staphylococcus aureus alpha-toxin depolarizes cells and causes them to leak monovalent cations; these effects are antagonized by extracellular Ca2+. Cells infected with vesicular stomatitis or Semliki Forest virus become depolarized during an infectious cycle; infection with other viruses was without affect on plasma membrane potential."
08/01/2012 - "Further studies reveal that divalent cations are essential for phage adsorption, while a monovalent cation (Na⁺) is required for the post-adsorption phase of phage infection. "
06/01/1989 - "These results suggest that shutoff of host and viral protein synthesis during infection by poliovirus mutant 2A-1 is a consequence of the virus-induced changes in intracellular monovalent cation concentrations."
08/01/1982 - "Infection of chick-embryo fibroblasts and other cells by certain animal viruses results in alterations in the intracellular concentrations of Na+ and K+. Dramatic alterations in monovalent-cation concentrations of lytic-virus-infected cells may favor the synthesis of viral proteins over cellular proteins. "

02/01/1993 - "The induction mechanism of gamete formation (gametogenesis) in a rodent malaria parasite, Plasmodium berghei, was investigated using Ca2+ antagonists, protein kinase inhibitors and amiloride, an inhibitor of monovalent cation/H+ exchange. "
10/13/1995 - "In this study of human erythrocytes infected in vitro with Plasmodium falciparum it was shown that the transport of monovalent cations (Rb+ and choline), but not that of a nonelectrolyte (sorbitol) or a monovalent anion (lactate), via the malaria-induced pathways is strongly dependent on the nature of the anion in the suspending medium. "
02/04/1994 - "5-Nitro-2-(3-phenyl-propylamino)benzoic acid (NPPB), furosemide, and niflumate blocked the malaria-induced transport of monovalent cations, neutral amino acids, sugars, nucleosides, and monovalent anions. "