Cathepsins

A group of lysosomal proteinases or endopeptidases found in aqueous extracts of a variety of animal tissues. They function optimally within an acidic pH range. The cathepsins occur as a variety of enzyme subtypes including SERINE PROTEASES; ASPARTIC PROTEINASES; and CYSTEINE PROTEASES.

Also Known As:

Networked: 1713 relevant articles (32 outcomes, 185 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kos, Janko: 44 articles (04/2022 - 01/2002)
2.	Turk, Boris: 39 articles (01/2022 - 01/2002)
3.	Bogyo, Matthew: 36 articles (01/2022 - 05/2004)
4.	Shi, Guo-Ping: 24 articles (01/2020 - 01/2004)
5.	Platt, Manu O: 21 articles (01/2022 - 08/2006)
6.	Reinheckel, Thomas: 20 articles (01/2021 - 03/2006)
7.	Blum, Galia: 19 articles (01/2022 - 10/2007)
8.	Joyce, Johanna A: 19 articles (01/2016 - 05/2004)
9.	Lalmanach, Gilles: 17 articles (10/2022 - 01/2006)
10.	Lecaille, Fabien: 15 articles (10/2022 - 07/2006)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2017 - "Elucidating the precise role of these cathepsins may lead to better understanding and more effective treatment of this aggressive tumor." 09/01/2020 - "However, cross-talk between tumor cells and MDSCs needs to be taken into account when studying the efficacy of cathepsin inhibitors as anti-cancer agents. " 01/01/2018 - "Here, we show an improved tumor-to-background ratio upon activation of our Turn-ON probes by cathepsins. " 07/14/2011 - "Cleared bands of cathepsin activity were identified and validated in tumor extracts and detected organ- and stage-specific differences in activity. " 04/01/2002 - "Positive results indicative of the presence of cathepsin were investigated to determine any correlation between a particular cathepsin and histologic malignancy grades, tumor cell growth, serum cathepsin activities, and clinical factors. "
2.	Rheumatoid Arthritis 10/18/2004 - "While it is likely that there are multiple targets of Au(I) in vivo, inhibition of the cathepsins would provide protection against the joint destruction that is a hallmark of rheumatoid arthritis and is one possible mechanism for Au(I) antiarthritic activity." 05/01/2011 - "The findings in this study support further investigation in the regulation of the activity of cathepsins and their inhibitors in erosive rheumatoid arthritis." 01/01/2022 - "Numerous cathepsins have their targeted role in rheumatoid arthritis. " 01/01/2022 - "Exploring the role of cathepsin in rheumatoid arthritis." 05/25/2005 - "Since rheumatoid arthritis is at the same time an inflammatory and joint destructive disorder, the combined inhibition of both cathepsins S and K should be beneficial. "
3.	Breast Neoplasms (Breast Cancer) 05/24/2023 - "Conversion of the cathepsin-activated probe, 6QC-Cy5, into a two-fluorophore probe, 6QC-RATIO, significantly improved signal-to-background in vitro and in a mouse subcutaneous breast tumor model. " 01/01/2016 - "In conclusion, the results of the present study indicated that the altered expression of cathepsins, in particular cathepsins B and D, contributed to the progression of breast cancer and poor disease-free survival in breast cancer patients." 01/01/2016 - "However, previous studies on the systematic analysis of the role of cathepsin family members in breast cancer are limited. " 01/01/2023 - "These findings indicate that cathepsin-targeted FGS has potential to improve treatment outcomes in breast cancer patients." 01/01/2021 - "Here, we studied the cathepsin-mediated secretome changes in the context of the MMTV-PyMT breast cancer mouse model. "
4.	Infections 01/01/2016 - "The objectives of this study were to investigate associations between numbers of CD163 and CD169 positive macrophages, cathepsin positive areolae, and type 2 PRRSV load at the maternal-fetal interface in order to examine important factors related to transplacental infection. " 03/01/2009 - "This study shows that disruption of BmNPV fp25K attenuates the expression of viral cathepsin gene (v-cath) at a late stage of infection, and thus reduces the secretion of its product V-CATH. " 11/01/2023 - "This modification allowed for productive infection, and a more detailed analysis showed that the virus might use the TMPRSS2-dependent pathway but can still bypass this pathway using cathepsin-mediated endocytosis. " 01/01/2023 - "HvKp infection resulted in different levels of pyroptosis via the activation of cathepsin B-NLRP3-caspase-1 in murine macrophages. " 08/03/2022 - "Additionally, most cathepsins were differentially expressed in the head kidney, gill, spleen, and liver following Aeromonas salmonicida infection, and their expression signatures showed tissue-specific and time-dependent patterns. "
5.	Inflammation (Inflammations) 03/01/2023 - "Cathepsins play significant roles in a number of illnesses by regulating parenchymal cell proliferation, cell migration, viral invasion, inflammation, and immunological responses through extracellular matrix remodeling, signaling disruption, leukocyte recruitment, and cell adhesion. " 01/01/2023 - "Cathepsin and cutaneous disorders of cornification and inflammation: their close links." 12/01/2022 - "Inflammation plays a major role in the reperfusion phase of IR injury and previous research has shown that cathepsins are key mediators of the inflammation cascade as well as apoptosis. " 12/01/2022 - "Cathepsins are involved in extracellular and systemic functions such as systemic inflammation and extracellular matrix degradation. " 04/01/2022 - "We here provide evidence that microglial cathepsin X strengthens microglia activation and leads to subsequent inflammation-induced neurodegeneration. "

Related Drugs and Biologics

1.	Cysteine (L-Cysteine)
2.	Peptide Hydrolases (Proteases)
3.	Peptides (Polypeptides)
4.	Cysteine Proteases (Cysteine Protease)
5.	Enzymes
6.	Cystatin C
7.	Matrix Metalloproteinases (MMPs)
8.	Cystatins
9.	Biomarkers (Surrogate Marker)
10.	Curcumin

Related Therapies and Procedures

1.	Therapeutics
2.	Radiotherapy
3.	Drug Therapy (Chemotherapy)
4.	Lasers (Laser)
5.	Computer-Assisted Surgery (Image Guided Surgery)