Cathepsin D

An intracellular proteinase found in a variety of tissue. It has specificity similar to but narrower than that of pepsin A. The enzyme is involved in catabolism of cartilage and connective tissue. EC 3.4.23.5. (Formerly EC 3.4.4.23).

Networked: 1320 relevant articles (19 outcomes, 193 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Liaudet-Coopman, Emmanuelle: 11 articles (09/2015 - 08/2002)
2.	Saftig, Paul: 11 articles (03/2013 - 02/2003)
3.	Isidoro, Ciro: 11 articles (02/2013 - 02/2002)
4.	Tyynelä, Jaana: 9 articles (02/2013 - 01/2003)
5.	Castino, Roberta: 8 articles (01/2010 - 02/2002)
6.	Laurent-Matha, Valérie: 7 articles (09/2015 - 01/2005)
7.	Derocq, Danielle: 7 articles (09/2015 - 08/2002)
8.	Follo, Carlo: 7 articles (02/2013 - 01/2006)
9.	Uchiyama, Yasuo: 6 articles (03/2013 - 02/2003)
10.	Prébois, Christine: 6 articles (12/2012 - 01/2005)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2010 - "While representative histologic sections from various disease-specific cohorts confirm previous findings that increased Cathepsin D production and secretion correlate with tumor progression, we report no difference in serum Cathepsin D activity between patients who are disease free, patients with pre-invasive or limited invasive disease, and patients with metastatic disease. " 05/01/2002 - "The cathepsin D levels, neither in the stroma nor in the tumor, showed no influence neither on the disease free intervals nor in the survival rates (p = 0.785; p = 0.355 and p = 0.614; p = 0.601 respectively). " 01/01/2012 - "The present study aims to assess the expression of Cathepsin D in malignant salivary gland tumors and to compare its expression in these tumors. " 07/01/2011 - "Mechanistic studies revealed that OLFM4 may exhibit its anticancer effects through regulating cell autophagy by targeting cathepsin D, as OLFM4 reduced cathepsin D protein levels and enzymatic activity and attenuated cathepsin D-induced cancer cell proliferation. " 01/07/2010 - "Earlier studies indicated that density-arrested cancer cells released an unidentified growth inhibitor whose secretion was prevented by overexpression of the lysosomal protease cathepsin D (cath D). "
2.	Breast Neoplasms (Breast Cancer) 03/01/2000 - "Invasive breast cancer patients were followed for up to 75 months to determine if the relative percentage amount of the 31 kDa form of cathepsin D was predictive of disease-free and overall survival. " 10/01/1992 - "Cathepsin D concentration in breast cancer cytosols: correlation with disease-free interval and overall survival." 01/01/1991 - "Therefore, measurement of cathepsin D appears to provide additional prognostic information for the prediction of disease-free and overall survival in patients with node negative breast cancer." 10/01/2013 - "The aim of this study was to evaluate clinical usefulness of cathepsin D status in early breast cancer during the first 3 years of follow-up. " 04/01/2005 - "This study suggests that elevated intratumoral cathepsin D levels may identify a subset of node-positive breast cancer patients showing a high probability of earlier death."
3.	Carcinoma (Carcinomatosis) 01/01/2005 - "Cathepsin D-related disease-free interval in pT1 primary breast carcinomas: a pilot study." 06/01/2012 - "To study the function of lymphangiogenesis and the expression of Cathepsin D (Cath-D) in laryngeal carcinoma metabasis and clinical pathology character. " 01/01/2008 - "The aim of the study was to determine the activity of cathepsin D (CTSD) and alpha-1-antitrypsin (AAT) in the blood serum of women with cervical carcinoma treated with different modes of therapy. " 09/01/2005 - "THE AIM of this study was to determine the activity of cathepsin D and alpha(1)-antitrypsin in the blood serum of patients with mammary carcinoma. " 05/01/2004 - "We have conducted a statistically powerful study of the prognostic value of conventional factors and of the investigational factors p53, Her2-neu and Cathepsin-D in patients with invasive breast carcinoma, in order to compare their significance. "
4.	Neoplasm Metastasis (Metastasis) 02/15/2000 - "We then summarize results of studies, mostly performed in our laboratory, aimed at understanding the effect of cathepsin D overexpression on metastasis and the molecular mechanisms involved. " 12/01/1999 - "Cathepsin-D is a potential independent predictor of cervical lymph node metastasis in HNSCC and merits additional study." 09/03/1994 - "Results obtain in our laboratory over the last 15 years allowed us to define cathepsin D, an oestrogen-regulated protein now under study as a prognostic marker for metastasis. " 01/01/2009 - "In a group of patients who survived one year post surgery, the percentage of cases with negative epithelial cathepsin D staining and without features of distant metastasis were higher. " 01/01/2009 - "The only factors significantly influencing one-year survival were epithelial cathepsin D staining and distant metastasis. "
5.	Amyloidosis 06/01/1995 - "Cathepsin D immunoreactivity was detected in marginal areas of amyloid deposits in spleens from patients with reactive amyloidosis. " 11/18/1996 - "A beta-amyloid peptide variant related with familial Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis is poorly eliminated by cathepsin D." 10/01/1975 - "The reduced incidence of amyloidosis following BAPN adminsitration cannot be due to lysosomal enzyme degradation of the amyloid as the activity of cathepsin D and acid phosphatase is decreased during this process." 06/01/1985 - "Levels of serum amyloid A (SAA) and the activities of cathepsin D, beta-N-glucosaminidase, serine esterase, lactate dehydrogenase (LDH) and gamma glutamyl transpeptidase (GGT) were measured in the blood plasma during induction of amyloidosis. " 04/01/2007 - "Proteins that were up-regulated in GBS included haptoglobin, serine/threonine kinase 10, alpha-1-antitrypsin, SNC73, alpha II spectrin, IgG kappa chain and cathepsin D preprotein, while transferrin, caldesmon, GALT, human heat shock protein 70, amyloidosis patient HL-heart-peptide 127aa and transthyretin were down-regulated. "

Related Drugs and Biologics

1.	Estrogens (Estrogen)
2.	Amyloid (Amyloid Fibrils)
3.	DNA (Deoxyribonucleic Acid)
4.	Acid Phosphatase
5.	Nitrogen
6.	milk-derived factor
7.	RNA (Ribonucleic Acid)
8.	Transferrin Receptors (Transferrin Receptor)
9.	Lysosome-Associated Membrane Glycoproteins
10.	Zeranol

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Lasers (Laser)
3.	Surgical Instruments (Clip)
4.	Renal Dialysis (Hemodialysis)
5.	Castration