Cathepsin B

A lysosomal cysteine proteinase with a specificity similar to that of PAPAIN. The enzyme is present in a variety of tissues and is important in many physiological and pathological processes. In pathology, cathepsin B has been found to be involved in DEMYELINATION; EMPHYSEMA; RHEUMATOID ARTHRITIS, and NEOPLASM INVASIVENESS.

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Networked: 1228 relevant articles (16 outcomes, 174 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Rao, Jasti S: 24 articles (05/2014 - 12/2002)
2.	Sloane, Bonnie F: 23 articles (03/2015 - 07/2002)
3.	Dinh, Dzung H: 16 articles (03/2013 - 12/2002)
4.	Gondi, Christopher S: 14 articles (10/2013 - 06/2004)
5.	Gujrati, Meena: 13 articles (03/2013 - 12/2002)
6.	Sameni, Mansoureh: 12 articles (03/2015 - 02/2002)
7.	Kos, Janko: 11 articles (08/2015 - 01/2002)
8.	Sloane, B F: 11 articles (09/2014 - 01/2000)
9.	Reinheckel, Thomas: 10 articles (03/2015 - 03/2006)
10.	Kos, J: 10 articles (07/2008 - 01/2000)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2015 - "At pH conditions relevant for tumors, cathepsin-B cleavage studies showed efficient release of the active toxin by SYD985 but not by T-DM1. " 03/01/2013 - "Numerous studies have shown that abnormal regulation of cathepsin B overexpression is correlated with invasive and metastatic phenotypes in cancers. " 12/01/2012 - "These findings are consistent with studies by others showing that deletion of cathepsin B in the transgenic MMTV-PyMT mice, a murine model that is predisposed to development of mammary cancer, reduces malignant progression." 01/01/2012 - "Our results indicate that cathepsin B may be a potential biomarker for further strategical clinical studies in cervical cancer." 01/01/2011 - "Earlier studies have reported important roles of uPA, uPAR and cathepsin B in tumor progression. "
2.	Carcinoma (Carcinomatosis) 04/01/1997 - "Serum cathepsin B-like activity may be helpful in the preoperative differential diagnosis between ovarian carcinomas and benign ovarian or uterine tumours." 01/01/1996 - "Recent clinical studies provide confirmatory evidence in that cathepsin B expression is a prognostic indicator in colon carcinoma." 02/01/2015 - "Overexpression of heparanase-1 and heparanase-2, along with increased heparanase-1 and cathepsin B activity in plasma, is associated with the diagnosis of gastrointestinal carcinoma. " 01/01/2012 - "It was found that cathepsin B expression in invasive carcinomas was significantly higher than that in the CINs and normal tissues (P<0.01). " 02/01/2011 - "High-risk HPV types may be associated with oral carcinoma, by cell-cycle control dysregulation, contributing to oral carcinogenesis and the overexpression of mdm2, p27 and cathepsin B."
3.	Pancreatitis 09/01/2006 - "Human pancreatitis and the role of cathepsin B." 09/01/2006 - "Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis." 09/01/2002 - "Our findings also suggest that pharmacological interventions that inhibit cathepsin B may prove useful in preventing acute pancreatitis or reducing its severity." 07/06/2001 - "Our results underlie the central role of cathepsin B in the development of different forms of pancreatitis." 07/01/2000 - "Water immersion also prevents the subcellular redistribution of cathepsin B from a lysosome-enriched fraction to a heavier, zymogen granule-enriched fraction that is known to occur in this model of pancreatitis. "
4.	Wounds and Injuries (Trauma) 01/01/2015 - "Cathepsin B expression is greatly up-regulated in TBI animal models, as well as in trauma patients. " 10/01/2014 - "We demonstrated an involvement of mouse intestinal cathepsin B in extracellular matrix remodeling for regeneration from trauma. " 03/01/2014 - "Therefore, this investigation evaluated mice with deletion of the cathepsin B gene receiving controlled cortical impact TBI trauma. " 05/01/2009 - "Because similar results were obtained with both mouse and rat intestine trauma models, we were interested in identifying potential targets of released cathepsin B in early post-traumatic phases. " 12/01/2004 - "Expression of cathepsin B was up-regulated and cathepsin B-positive vesicles showed a redistribution from perinuclear to peripheral regions of keratinocytes at the wound margins within 4 h after wounding. "
5.	Edema 12/01/1992 - "CS administration (15 milligrams, twice a day) for 14 days caused a significant increase in serum amylase levels, pancreatic amylase and cathepsin B content and mild acinar cell vacuolization and interstitial edema. " 04/01/2007 - "The features of cell death, including 7-AAD staining, the presence of cellular edema, and early membrane damage resulting in lactate dehydrogenase (LDH) release, indicated that it was more likely to be necrosis than apoptosis, and was effectively blocked with the cathepsin B-specific inhibitor CA-074-Me. " 04/01/1990 - "Hemorrhagic shock did not alter the degree of hyperamylasemia, pancreatic edema, cathepsin B subcellular redistribution, or in vitro LDH leakage that characterize this model of pancreatitis. " 05/01/1992 - "After PBDO with ischemia, we observed hyperamylasemia, pancreatic edema, congestion of amylase and lysosomal enzyme cathepsin B as well as impaired output of amylase and cathepsin B into the pancreatic juice and a redistribution of lysosomal enzyme from the lysosomal fraction to the zymogen fraction. " 04/01/1993 - "Twelve hours after PBDO with IDH plus ISCH, we observed hyperamylasemia (23 +/- 3 units per milliliter) (p < 0.01); moderate pancreatic histologic changes; pancreatic edema (water content--81 +/- 2 percent) (p < 0.02), as well as the impaired amylase (2,889 +/- 328 units per kilogram per hour) (p < 0.01) and cathepsin B output (7 +/- 3 units per kilogram per hour) (p < 0.01) into the pancreatic juice of rats stimulated by caerulein (control group--serum amylase levels, 6 +/- 1 units per milliliter; pancreatic water content, 74 +/- 1 percent. "

Related Drugs and Biologics

1.	Caerulein (Ceruletide)
2.	Protease Inhibitors (Protease Inhibitor)
3.	Malate Dehydrogenase (Dehydrogenase, Malate)
4.	Amylases
5.	Laminin (Merosin)
6.	Cystatin C
7.	Amyloid Precursor Protein Secretases (beta-Secretase)
8.	Galactosamine
9.	Amyloid (Amyloid Fibrils)
10.	Leukocyte Elastase (Neutrophil Elastase)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Drug Therapy (Chemotherapy)
3.	Therapeutics
4.	Ligation
5.	Intraperitoneal Injections