Catechol Estrogens

2- or 4-Hydroxyestrogens. Substances that are physiologically active in mammals, especially in the control of gonadotropin secretion. Physiological activity can be ascribed to either an estrogenic action or interaction with the catecholaminergic system.

Also Known As:

Networked: 164 relevant articles (1 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bolton, Judy L: 5 articles (01/2011 - 07/2002)
2.	Chang, Minsun: 4 articles (04/2021 - 07/2002)
3.	Zahid, Muhammad: 4 articles (10/2020 - 01/2005)
4.	Khan, Wahid Ali: 4 articles (09/2020 - 02/2011)
5.	Saeed, Muhammad: 4 articles (08/2010 - 01/2005)
6.	Cavalieri, Ercole: 3 articles (04/2007 - 01/2005)
7.	Rogan, Eleanor: 3 articles (04/2007 - 01/2005)
8.	Chen, Zhi-Hua: 3 articles (10/2005 - 10/2004)
9.	Hurh, Yeon-Jin: 3 articles (10/2005 - 10/2004)
10.	Na, Hye-Kyung: 3 articles (10/2005 - 10/2004)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "In conclusion, COMT may act as tumor suppressor in ER dependent BC not only by detoxification of catechol estrogens but also by suppressing cell invasion and interplay with MET pathway." 01/01/2014 - "Schistosome and liver fluke derived catechol-estrogens and helminth associated cancers." 05/01/2009 - "The relatively high levels of catechol estrogens detected in milk products support the theory that milk consumption is a source of EM and their ingestion may have a dietary influence on cancer risk." 01/01/2006 - "This is essential information for understanding the cancer risk posed by oxidation of the two catechol estrogens." 01/09/2001 - "DNA damage caused by catechol estrogens has been shown to play an etiologic role in tumor formation. "
2.	Breast Neoplasms (Breast Cancer) 10/01/2020 - "Despite the demonstrated genotoxic properties of certain catechol estrogens resulting in EDAs, this analysis did not provide evidence for an increased breast cancer risk in relation to an elevated EDA:EMC. " 06/01/2013 - "Polymorphisms of catechol estrogens metabolism pathway genes and breast cancer risk in Mexican women." 05/15/2009 - "Src supports UDP-glucuronosyltransferase-2B7 detoxification of catechol estrogens associated with breast cancer." 04/01/2008 - "On the sulfation and methylation of catecholestrogens in human mammary epithelial cells and breast cancer cells." 05/01/2007 - "These results support the hypothesis that the formation and accumulation of catechol estrogens in breast tissue through increased CYP1B1 expression and reduced COMT expression may play a significant role in breast cancer risk."
3.	Carcinogenesis 01/01/2017 - "A genetic variant Val158Met in the COMT gene leads to a several-fold decrease in the enzymatic activity giving rise to the accumulation of potentially carcinogenic endogenous catechol estrogens and their reactive intermediates and increasing thus the risk of tumorigenesis. " 02/01/2013 - "Catecholestrogens [4-hydroxyestradiol (4-OHE(2))] have been implicated in human carcinogenesis, although the mechanism remains unestablished. " 09/01/2007 - "Since catechol estrogens possess carcinogenetic potential, their detoxification may lead to reduced risk of carcinogenesis. " 01/01/1997 - "[Catecholestrogens: synthesis, properties and role in carcinogenesis]." 01/01/2021 - "Catechol estrogens (CEs) are known to be toxic metabolites and the initiators of the oncogenesis of breast cancers via forming covalent adducts with DNAs. "
4.	Prostatic Neoplasms (Prostate Cancer) 01/01/2001 - "The implication of catechol estrogens in the biogenesis of breast and prostate cancer makes these labile lipophilic compounds important analytical targets. " 09/01/2007 - "The proposed method was applied to the simultaneous determination of catechol estrogens in spiked urine in a preliminary study on estrogens and PSA values in biopsy and prostate cancer patients." 09/01/2007 - "Improvement of the sensitivity and specificity of a simultaneous stress-free screening method for catechol estrogens as a potential prostate cancer marker in urine has been accomplished by HPLC with a diamond-electrode electrochemical detector and a fluorescence detector. " 09/01/2007 - "HPLC for stress-free screening of potential prostate cancer marker catechol estrogens in urine using a diamond-electrode electrochemical and a fluorescence detector." 07/01/2018 - "Reciprocally, it was found that estradiol and catechol estrogens significantly induced the expression of SphK1 while methoxylated catechol estrogen suppressed its expression within prostate cancer cells in a dose-dependent manner. "
5.	Endometrial Neoplasms (Endometrial Cancer) 04/01/2004 - "Our data suggest, that the CYP1B1 Ser allele may decrease endometrial cancer risk by altering the production of catechol estrogens. " 01/01/1986 - "These data demonstrate the importance of minor estrogens, including catechol estrogens, and of their ratios with the classical ones, in studies of steroid metabolism in both breast and endometrial cancer. "

Related Drugs and Biologics

1.	Catechol O-Methyltransferase (Methyltransferase, Catechol)
2.	2-Methoxyestradiol
3.	Estrogens (Estrogen)
4.	Estradiol (Delestrogen)
5.	catechol (pyrocatechol)
6.	Estrone
7.	Steroids
8.	Quercetin
9.	Progesterone
10.	Flavonoids

Related Therapies and Procedures

1.	Electrodes (Electrode)