Catastrophic Illness

An acute or prolonged illness usually considered to be life-threatening or with the threat of serious residual disability. Treatment may be radical and is frequently costly.

Also Known As:

Networked: 36 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Septic Shock (Toxic Shock Syndrome)
2.	Respiratory Insufficiency (Respiratory Failure)
3.	Acute Kidney Injury (Acute Renal Failure)
4.	Lethargy
5.	Acute Liver Failure (Fulminant Hepatic Failure)

Experts

1.	Scheinhorn, David J: 3 articles (01/2007 - 07/2002)
2.	Chao, David C: 3 articles (01/2007 - 07/2002)
3.	Huang, Nicole: 2 articles (09/2015 - 07/2015)
4.	Tsai, Wen-Chen: 2 articles (08/2014 - 03/2011)
5.	Kung, Pei-Tseng: 2 articles (08/2014 - 03/2011)
6.	Petrak, Richard A: 2 articles (01/2007 - 01/2007)
7.	Epstein, Scott K: 2 articles (01/2007 - 01/2007)
8.	Votto, John J: 2 articles (01/2007 - 01/2007)
9.	Doig, Gordon S: 2 articles (01/2007 - 01/2007)
10.	Ventilation Outcomes Study Group: 2 articles (01/2007 - 01/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Catastrophic Illness:

1.	Urea (Carbamide)FDA LinkGeneric 05/01/2012 - "Of particular concern are unsuspected inherited defects of the urea cycle and fatty acid oxidation presenting with catastrophic illness in previously normal individuals. " 02/01/1994 - "Inborn errors of urea synthesis can present in the newborn period as a catastrophic illness or later in childhood or adulthood with an indolent course punctuated by hyperammonemic episodes. "
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/01/1991 - "Tumor necrosis factor (TNF), a cytokine that is often over-produced during Gram-negative or Gram-positive infection, occupies a critical role in triggering this catastrophic illness. "
3.	Methylmalonic AcidIBA 02/01/1982 - "Inclusion of a simple urine screening test for methylmalonic acid is recommended in the workup of infants with episodic vomiting, lethargy, acidosis, or catastrophic illness."
4.	MercuryIBA 01/01/1991 - "[Medical testimony on the life and work conditions of miners in Almaden in the second half of the 18th century: the prologue of The catastrophic illness of the mercury mines of the village of Almaden del Azogue (1778) by José Parés y Franqués (+1798)]."
5.	IronIBA 07/01/1993 - "Excess iron and catastrophic illness."
6.	FluoridesIBA 03/01/2011 - "Research revealed that fluoride varnish is used by up to 9.84% of children with disability; the use increases with age and decreases with increased level of disability, but is remarkably higher in those with catastrophic illness/injury. "
7.	Dacarbazine (DIC)FDA LinkGeneric 07/01/2002 - "A 21-year-old woman in the 27th week of gestation developed a catastrophic illness characterized by fever, progressive pneumonia, respiratory failure, leukopenia, disseminated intravascular coagulation (DIC), anicteric hepatitis, septic shock and acute renal failure. "
8.	Adrenal Cortex Hormones (Corticosteroids)IBA 04/01/1992 - "The clinical course may be indolent, or patients may develop a sudden catastrophic illness, particularly following the administration of corticosteroids."
9.	Acute fatty liver of pregnancyIBA 03/01/2008 - "Acute fatty liver of pregnancy is a sudden catastrophic illness occurring almost exclusively in the third trimester; microvesicular fatty infiltration of hepatocytes causes acute liver failure with coagulopathy and encephalopathy. "
10.	natalizumab (Tysabri)FDA Link 02/01/2008 - "PML has now emerged as a catastrophic illness in multiple sclerosis with biologic drug therapy (natalizumab) and reported in rheumatic diseases with and without biologic therapeutic agents. "

Therapies and Procedures

1.	Intensive Care (Surgical Intensive Care) 01/01/2000 - "Survivors of catastrophic illness: outcome after direct transfer from intensive care to extended care facilities." 04/01/2006 - "Morbid obesity (body mass index > or =40 kg/m(2)) is an independent risk factor for death in surgical patients with catastrophic illness requiring prolonged intensive care. " 07/01/2014 - "Paralytic poliomyelitis, Reye syndrome, Hemophilus Influenzae type B epiglottitis, bacterial meningitis, and meningococcal septic shock are catastrophic illnesses that in the last 60 years have shaped the development of pediatric intensive care. "
2.	Mechanical Ventilators (Ventilator) 01/01/2000 - "Instead, when conversations about death were reported, they had been largely limited to the scenarios of catastrophic illness (e.g., hospitalization, ventilator, etc.) and the Living Will. " 01/01/2007 - "This is the first multicenter study to characterize ventilator-dependent survivors of catastrophic illness admitted to the post-ICU venue of LTCHs for weaning from prolonged mechanical ventilation (PMV). " 01/01/2007 - "In the continuum of critical care medicine, more than half of ventilator-dependent survivors of catastrophic illness transferred from the ICU were successfully weaned from prolonged mechanical ventilation in the setting of an LTCH." 01/01/2007 - "Ventilator-dependent survivors of catastrophic illness transferred to 23 long-term care hospitals for weaning from prolonged mechanical ventilation."
3.	Critical Care 01/01/2011 - "Predictive monitoring for early detection of subacute potentially catastrophic illnesses in critical care." 01/01/2007 - "In the continuum of critical care medicine, more than half of ventilator-dependent survivors of catastrophic illness transferred from the ICU were successfully weaned from prolonged mechanical ventilation in the setting of an LTCH." 01/01/2015 - "The resulting loss of gas exchange leads to acute respiratory failure and typically catastrophic illness, termed acute respiratory distress syndrome (ARDS), requiring ventilatory and critical care support. "
4.	Highly Active Antiretroviral Therapy (HAART) 04/01/2009 - "The 25th anniversary of the first reports of a catastrophic illness later classified as AIDS and the 10th anniversary of highly active antiretroviral therapy (HAART) both occurred in 2006. " 01/01/2006 - "The introduction of highly active antiretroviral therapy (HAART) has transformed human immunodeficiency virus (HIV) infection from a rapidly progressive catastrophic illness to a chronic condition. "
5.	Transplantation (Transplant Recipients) 04/01/2014 - "All liver transplant recipients in the catastrophic illness database from 2000 to 2009 were enrolled. " 05/01/2009 - "Liver failure is a catastrophic illness associated with the death of many patients who are waiting for transplantation. "