A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. The limbs tend to remain in whatever position they are placed (waxy flexibility). Catalepsy may be associated with PSYCHOTIC DISORDERS (e.g., SCHIZOPHRENIA, CATATONIC), nervous system drug toxicity, and other conditions.
Also Known As:
Anochlesia; Anochlesias; Catalepsies; Flexibilitas, Cerea; Flexibilities, Waxy; Waxy Flexibilities; Waxy Flexibility; Cerea Flexibilitas; Flexibility, Waxy
Networked: 2014 relevant articles (81 outcomes, 195 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Hypothermia
2. Parkinson Disease (Parkinson's Disease)
3. Parkinsonian Disorders (Parkinsonism)
4. Tremor (Tremors)
5. Muscle Rigidity


1. Kulikov, A V: 29 articles (01/2015 - 07/2001)
2. Popova, N K: 23 articles (01/2015 - 08/2002)
3. Tikhonova, M A: 16 articles (01/2015 - 08/2002)
4. Svensson, Torgny H: 15 articles (05/2012 - 11/2002)
5. Wiley, Jenny L: 13 articles (05/2015 - 06/2003)
6. Bazovkina, D V: 13 articles (02/2014 - 01/2006)
7. Ohno, Yukihiro: 10 articles (11/2015 - 10/2008)
8. Lichtman, Aron H: 10 articles (08/2015 - 08/2002)
9. Schmidt, W J: 10 articles (03/2011 - 08/2000)
10. Koek, Wouter: 10 articles (09/2008 - 10/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Catalepsy:
1. Haloperidol (Haldol)FDA LinkGeneric
2. Levodopa (L Dopa)FDA LinkGeneric
3. Tetrahydrocannabinol (THC)FDA LinkGeneric
4. Dopamine (Intropin)FDA LinkGeneric
5. Amphetamine (Amfetamine)FDA LinkGeneric
6. Morphine (MS Contin)FDA LinkGeneric
7. Reserpine (Serpasil)FDA Link
8. RacloprideIBA
9. Antipsychotic Agents (Antipsychotics)IBA
10. Dopamine Receptors (Dopamine Receptor)IBA

Therapies and Procedures

1. Analgesia
2. Injections
3. Oral Administration
01/01/2001 - "DHA-clozapine is a long-acting central depressant with powerful and prolonged antidopaminergic activity after oral administration or injection without inducing catalepsy, and it markedly reduced peripheral exposure to free clozapine. "
08/15/2010 - "A high-throughput screening campaign identified 4-((E)-styryl)-pyrimidin-2-ylamine (11) as a positive allosteric modulator of the metabotropic glutamate (mGlu) receptor subtype 4. An evaluation of the structure-activity relationships (SAR) of 11 is described and the efficacy of this compound in a haloperidol-induced catalepsy rat model following oral administration is presented."
12/01/2008 - "Oral administration of Co Q10 in a low dose 200 mg/kg/day (group III) or a high dose 600 mg/kg/day (group IV), resulted in amelioration of the mitochondrial induced apoptosis by dose-dependent restoration of striatal complex I activity, ATP levels with temperate increase in expression of Bcl-2 as well as decrease in catalepsy score. "
11/01/1986 - "CM 30366 induced stereotyped behaviour and antagonized haloperidol-induced catalepsy in rats, after parenteral and oral administration. "
12/01/2008 - "As a current replacement therapy, oral administration of levodopa 10 mg/kg/day (group V), caused symptomatic improvement in the form of reduction of catalepsy score with restoration of striatal dopamine levels, but it did not show any significant effects on either striatal complex I activity, ATP levels or the expression of Bcl-2, pointing to the lack of its disease-modifying role. "
4. Hypnosis (Mesmerism)
5. Intraperitoneal Injections