Cascara

10/01/2015 - "We have reviewed the most common botanical laxatives such as senna, cascara, frangula, aloe, and rhubarb and their use in the treatment of constipation. "
07/01/2004 - "We conducted a double blind study with 3 groups (placebo, ear mushrooms alone, and ear mushrooms with additives including cascara sagrada, etc.), which were randomly assigned out of 34 patients with functional constipation, defined by modified Rome II criteria. "
11/01/1982 - "[Clinical experience with a preparation containing cascara sagrada and boldo in the therapy of simple constipation in the elderly]."
03/22/1884 - "A Report of Three Hundred and Five Cases of Habitual and Temporary Constipation Treated with Cascara Sagrada."
07/14/1883 - "Cascara Sagrada in Constipation."

03/19/1996 - "Anthraquinone glycosides of Senna and Cascara were investigated for their ability to induce aberrant crypt foci (ACF) in the rat colon mucosa, which are considered putative preneoplastic lesions. "
09/07/2001 - "Effect of bisacodyl and cascara on growth of aberrant crypt foci and malignant tumors in the rat colon."
09/07/2001 - "The present study was designed to investigate the effects of bisacodyl (4.3 and 43 mg/kg) and cascara (140 and 420 mg/kg) on azoxymethane (AOM)-induced aberrant crypt foci (ACF) and tumors. "

09/07/2001 - "Cascara (140 and 420 mg/kg) did not induce the development of colonic ACF and tumors and did not modify the number of AOM-induced ACF and tumors. "
09/07/2001 - "Effect of bisacodyl and cascara on growth of aberrant crypt foci and malignant tumors in the rat colon."
09/07/2001 - "The present study was designed to investigate the effects of bisacodyl (4.3 and 43 mg/kg) and cascara (140 and 420 mg/kg) on azoxymethane (AOM)-induced aberrant crypt foci (ACF) and tumors. "

06/01/2015 - "The use of anthranoid laxatives such as Cascara sagrada can, in rare instances, produce a hepatitis that resolves with discontinuation of the offending supplement. "
06/01/2015 - "This case report describes a local patient diagnosed with an extrahepatic cholangiocarcinoma following workup for an acute hepatitis due to ingestion of large quantities of Cascara sagrada. "
12/01/2000 - "In the present case report, cascara sagrada (CS) has been associated with the development of cholestatic hepatitis, complicated by portal hypertension. "

11/09/2009 - "[Toxic hepatitis following consumption of the herbal medicinal product Cascara Sagrada]."
11/09/2009 - "This case report presents a patient who developed severe toxic hepatitis with beginning liver failure following four weeks of consumption of the herbal medicinal product Cascara Sagrada. "