Cartilage Diseases (Cartilage Disease)

07/01/2004 - "A more complete understanding of the role of TGF-beta and its down-stream signals will lead to improved understanding and treatment of cartilage diseases."
08/01/2000 - "Since TGFbeta is a key factor in age-related cartilage diseases, the purpose of the present study was to determine whether TGase from aging articular chondrocytes participates in LTGFbeta activation. "
06/01/2008 - "Dysregulation of TGF-beta action has been implicated in cartilage diseases such as osteoarthritis. "
01/01/2006 - "These findings show a key role for BMP signaling during the chondrocyte maturation, occurring with loss of TGF-beta signaling with important implications for osteoarthritis and cartilage diseases."
07/01/1997 - "These differences in TGFbeta response are likely to contribute to the development of age-associated cartilage diseases such as osteoarthritis."

06/01/2019 - "Prospective, Randomized, Double-Blind Evaluation of the Efficacy of a Single-Dose Hyaluronic Acid for the Treatment of Patellofemoral Chondromalacia."
07/01/2000 - "Therefore, we conclude that the use of hyaluronan may be indicated during the early stages of chondromalacia."
01/01/2019 - "High molecular weight hyaluronan (H-HA) has a pivotal role in the maintenance of normal functions of synovial fluid and structure of the articular joint, but it has been shown that its concentration is reduced in patients affected by degenerative cartilage diseases, such as osteoarthritis (OA). "
04/01/1994 - "The effects of intraarticular hyaluronan do not differ significantly from those of placebo in patients with knee pain and cartilage disease."
10/31/2018 - "The physicians participating in the study injected the hyaluronic acid, in that case, Biolevox HA, to the knee joint, in patients with osteoarthritis, chondromalacia, knee joint injuries and other conditions."

01/01/2017 - "The peptide CK2.1 could be a powerful tool in understanding the signaling pathways contributing to the repair process, and also may be used as a potential therapeutic for treating degenerative cartilage diseases such as OA."
04/01/1993 - "Since folding of the type II collagen polypeptides to the triple helix is initiated from the carboxyl-terminal end, it has been suggested that mutations in this region typically result in severe cartilage diseases. "

05/01/2007 - "Studies in chondrocytes and cartilage biopsies suggest that the cartilage disease is caused by retention of mutant COMP in the endoplasmic reticulum of chondrocytes and by disruption of the collagen network of the extracellular matrix. "
02/01/1998 - "The aim of the study was to determine collagen concentration and collagen crosslinks in cartilage samples from chondromalacia of the patella. "
11/01/2017 - "It is sensitive to collagen damage or degeneration and may be useful for evaluating the status of knee diseases, such as meniscal tears and cartilage disease. "
03/01/2014 - "T2 mapping in patients with PFS demonstrates increased cartilage T2 in the medial patellar facet, possibly reflecting collagen alteration from early chondromalacia (softening) or increased water content related to altered contact pressures."
08/01/2009 - "In conclusion, the newly uncovered impact of ADAM15 on signalling events that arise from chondrocyte interactions with its collagen matrix might contribute to the elucidation of the mechanism underlying its proposed chondroprotective role in degenerative cartilage disease."

08/18/2023 - "Chondromalacia patella (CMP) is abnormal softening of the cartilage of the underside the patella. "
11/08/2022 - "However, the relationship between chondromalacia patella (CMP) and HZ remains poorly understood. "
04/01/2021 - "Material and Methods A prospective study of first 80 patients who were diagnosed with chondromalacia patella (CMP) on magnetic resonance imaging (MRI) divided into early and late CMP groups were evaluated clinically, radiologically, and in terms of functional outcome. "
02/01/2018 - "As chondromalacia stage advances, the symptom severity worsens and knee functions decline; however, MRI measurements do not show difference between early and advanced stage CMP patients."
01/01/1985 - "The purpose of this pilot study was to identify those clinical exam findings most often seen in patients with a positive chondromalacia patella (CMP) arthroscopic exam. "

01/01/2023 - "Recent studies have demonstrated that miRNAs play significant roles in bone formation, suggesting that miRNAs may be novel therapeutic targets for bone and cartilage diseases. "
03/01/2020 - "Our data imply that genetic variations in miRNAs linked to OA pathogenesis may regulate their expression levels, suggesting new therapeutic strategies for patients with cartilage diseases."
11/01/2016 - "This article reviews work on Runx2 and miRNA regulation in bone and cartilage diseases."
11/01/2016 - "Runx2 and microRNA regulation in bone and cartilage diseases."
04/01/2015 - "Dysregulation of miR-26a expression could contribute to ECM changes in cartilage diseases and this miRNA may therefore act as a therapeutic target. "

11/01/1996 - "This study demonstrates that fat-suppressed routine T2-weighted and fast spin echo T2-weighted sequences seem to be more accurate than proton density, T1-weighted, and gradient echo sequences in grading chondromalacia. "
01/01/1993 - "Stage III and IV chondromalacia is reliably evaluated with MR using the combination of proton density and T2-weighted images."
01/01/1992 - "MR diagnosis based on the criteria of focal signal or focal contour abnormality on either the T2-weighted or proton density-weighted images yielded the highest correlation with the arthroscopic diagnosis of chondromalacia. "
09/01/1994 - "All imaging techniques studied had high specificity and accuracy in the detection and grading of chondromalacia patella; however, both MR arthrography and CT arthrography were more sensitive than T1-weighted, proton density-weighted, and SPGR with fat saturation MR imaging for showing intermediate grades of chondromalacia patellae. "

10/01/1990 - "The effect of glycosaminoglycan polysulfate (GAGPS) on damaged patellar cartilage and clinical symptoms of chondromalacia was studied on 31 patients in a placebo-controlled double-blind trial. "
10/01/1995 - "Polysulfated glycosaminoglycans (PSGAG) are widely used to treat cartilage disease in horses. "

08/07/2020 - "This study supports a role for sncRNAs in ageing cartilage and their potential involvement in age-related cartilage diseases."

01/01/1991 - "Furthermore, the use of synthetic oligonucleotides without cloning the gene of interest could increase the usefulness of the technique in studies on human cartilage diseases and possibly on other diseases."

04/01/2018 - "A 21-year-old woman with recurrent lateral patellar instability caused by severe trochlear dysplasia and concomitant grade-IV trochlear chondromalacia was treated successfully with osteoarticular allograft transplantation of the entire trochlear groove. "
01/01/2017 - "With the development of tissue engineering, repairing cartilage defects through transplantation of engineered cartilage that closely matches properties of native cartilage has become a new option for curing cartilage diseases. "
01/01/2014 - "The Autologous Chondrocytes Transplantation (ACT) method is being studied for repair of cartilage diseases. "
03/01/2009 - "Recently, cartilage diseases have been treated by auto- or allogenic chondrocyte transplantation. "
10/06/1994 - "A mean of 36 months after transplantation, the results were excellent or good in two of the seven patients with patellar transplants, fair in three, and poor in two; two patients required a second operation because of severe chondromalacia. "

08/01/1982 - "In both series, all patients recovered following meniscectomy, with the exception of one patient in our series, who developed chondromalacia patella from an unrelated patellar abnormality."
10/01/2006 - "Case series; Level of evidence, 4. Between 1982 and 2001, 135 patients met the study criteria of a partial medial meniscectomy, intact ligaments, no surgery to the contralateral knee, and no chondromalacia greater than grade II. Seventy-nine patients living within 150 miles of the clinic were asked to return for physical examination. "
01/01/1993 - "The purpose of this study was to determine the influence of preexisting chondromalacia at time of surgery on the results at a minimum of 5 years follow-up of arthroscopic partial meniscectomy. "
01/01/2013 - "Tapper-Hoover: in 23 patients underwent partial meniscectomy: 17 were classified grade I, 5 grade II, 1 grade III; in 5 patients underwent total/subtotal meniscectomy: 2 were classified grade II and 3 grade III. These ones evidenced further signs of chondromalacia on articular surfaces, in the lateral area of knee joint. "
09/01/2010 - "Symptomatic early-onset chondromalacia often develops after a meniscectomy in the affected knee compartment. "

01/01/1997 - "After 2 years, the results of the laser collective were significantly improved, whereas the results for the conventional collective, especially for chondromalacia and synovialitis, did not show the same improvement. "
03/01/1997 - "Therefore, laser treatment of chondromalacia cannot be recommended. "
03/01/1997 - "After laser treatment of local chondromalacia, large cartilage lesions with less tendency towards repair were more often seen than after conventional arthroscopic treatment. "
01/01/1991 - "A randomized, double blind study of low level laser treatment of chondromalacia of the patella in 40 patients has been undertaken. "
01/01/1990 - "One hundred and forty patients stage II or III chondromalacia according to Outerbridge were randomly assigned to arthroscopic operation using either laser or mechanical instruments. "

11/01/1998 - "This article describes the results of treating temporomandibular joint (TMJ) articular disc perforation and advanced chondromalacia arthroscopically by the use of discoplasty and abrasion arthroplasty. "
11/01/1998 - "Arthroscopic management of temporomandibular joint disc perforations and associated advanced chondromalacia by discoplasty and abrasion arthroplasty: a supplemental report."
08/01/1994 - "Grade IV chondromalacia with exposed bone was treated by abrasion arthroplasty with the goal of resurfacing the bone with fibrocartilage. "
08/01/1994 - "Arthroscopic management of temporomandibular joint disc perforations and associated advanced chondromalacia by discoplasty and abrasion arthroplasty: preliminary results."
01/01/2010 - "Newer techniques that combine patellofemoral arthroplasty with autologous osteochondral transplantation or unicompartmental arthroplasty appear to be effective for patients with associated tibiofemoral chondromalacia."

04/01/2012 - "Fast increase of MSC knowledge and techniques has led to some successful clinical trials and helped devising new tissue engineering therapies for bone and cartilage diseases that severely afflict human health. "
01/01/2022 - "This study demonstrates how the Raman spectroscopic method could support and accelerate the development of new therapies for cartilage diseases."
02/01/2012 - "Further studies are therefore required to estimate the long-term sustainability of these cells in the native tissue, to identify well suited delivery materials and to have a thorough understanding of the mechanism of interaction between the chondrocytes and extracellular matrix and time is not far when this cell based therapy will provide a comprehensive cure to cartilage disease."
10/01/2000 - "Imaging strategies that allow visualization of cartilage integrity would revolutionize the field by allowing us to visualize early stages of degeneration and thus to evaluate predisposing factors for cartilage disease and changes resulting from interventions (eg, therapies) in culture studies, tissue-engineered systems, animal models, and in vivo in humans. "
01/01/1994 - "To ascertain the efficiency of different techniques of arthroscopic therapy for gonarthritis and establish the relevance of the extent of chondromalacia, clinical and experimental studies were performed. "