Cartilage Diseases (Cartilage Disease)

07/01/2004 - "A more complete understanding of the role of TGF-beta and its down-stream signals will lead to improved understanding and treatment of cartilage diseases."
08/01/2000 - "Since TGFbeta is a key factor in age-related cartilage diseases, the purpose of the present study was to determine whether TGase from aging articular chondrocytes participates in LTGFbeta activation. "
06/01/2008 - "Dysregulation of TGF-beta action has been implicated in cartilage diseases such as osteoarthritis. "
01/01/2006 - "These findings show a key role for BMP signaling during the chondrocyte maturation, occurring with loss of TGF-beta signaling with important implications for osteoarthritis and cartilage diseases."
07/01/1997 - "These differences in TGFbeta response are likely to contribute to the development of age-associated cartilage diseases such as osteoarthritis."

05/01/2007 - "Studies in chondrocytes and cartilage biopsies suggest that the cartilage disease is caused by retention of mutant COMP in the endoplasmic reticulum of chondrocytes and by disruption of the collagen network of the extracellular matrix. "
02/01/1998 - "The aim of the study was to determine collagen concentration and collagen crosslinks in cartilage samples from chondromalacia of the patella. "
03/01/2014 - "T2 mapping in patients with PFS demonstrates increased cartilage T2 in the medial patellar facet, possibly reflecting collagen alteration from early chondromalacia (softening) or increased water content related to altered contact pressures."
08/01/2009 - "In conclusion, the newly uncovered impact of ADAM15 on signalling events that arise from chondrocyte interactions with its collagen matrix might contribute to the elucidation of the mechanism underlying its proposed chondroprotective role in degenerative cartilage disease."
05/01/1999 - "Increasingly severe cartilage disease was associated with progressive and selective degeneration of the collagen framework of the beak ligament at its insertion onto the thumb metacarpal. "

11/01/1996 - "This study demonstrates that fat-suppressed routine T2-weighted and fast spin echo T2-weighted sequences seem to be more accurate than proton density, T1-weighted, and gradient echo sequences in grading chondromalacia. "
01/01/1993 - "Stage III and IV chondromalacia is reliably evaluated with MR using the combination of proton density and T2-weighted images."
01/01/1992 - "MR diagnosis based on the criteria of focal signal or focal contour abnormality on either the T2-weighted or proton density-weighted images yielded the highest correlation with the arthroscopic diagnosis of chondromalacia. "
09/01/1994 - "All imaging techniques studied had high specificity and accuracy in the detection and grading of chondromalacia patella; however, both MR arthrography and CT arthrography were more sensitive than T1-weighted, proton density-weighted, and SPGR with fat saturation MR imaging for showing intermediate grades of chondromalacia patellae. "

10/01/1990 - "The effect of glycosaminoglycan polysulfate (GAGPS) on damaged patellar cartilage and clinical symptoms of chondromalacia was studied on 31 patients in a placebo-controlled double-blind trial. "
10/01/1995 - "Polysulfated glycosaminoglycans (PSGAG) are widely used to treat cartilage disease in horses. "

11/01/2010 - "A recent study reported that 2,3,7,8,-tetrachlorodibenzo-p-dioxin (TCDD) induces apoptosis in chondrocytes, which is a critical event in the pathogenesis of cartilage disease. "

01/01/1991 - "Furthermore, the use of synthetic oligonucleotides without cloning the gene of interest could increase the usefulness of the technique in studies on human cartilage diseases and possibly on other diseases."

02/01/1998 - "To study the extracellular matrix alterations associated to chondromalacia, we determined the concentration of collagen (hydroxyproline) and its hydroxylysylpyridinoline and lysylpyridinoline crosslinks from chondromalacia foci of the patellae in 12 patients and 7 controls from apparently normal cadavers. "

11/03/2010 - "The aims of this study were to investigate the potential of delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) to detect cartilage disease in asymptomatic hips with cam deformities compared with morphologically normal hips, establish whether dGEMRIC could identify advanced disease in hips with positive clinical findings, and establish whether cartilage damage correlated with the severity of the cam deformity. "

02/01/1998 - "The full-thickness cartilage samples taken with a surgical knife from chondromalacia lesions did not show changes in collagen, hydroxylysylpyridinoline and lysylpyridinoline concentration as compared with the controls. "
02/01/1998 - "To study the extracellular matrix alterations associated to chondromalacia, we determined the concentration of collagen (hydroxyproline) and its hydroxylysylpyridinoline and lysylpyridinoline crosslinks from chondromalacia foci of the patellae in 12 patients and 7 controls from apparently normal cadavers. "

02/01/1998 - "The full-thickness cartilage samples taken with a surgical knife from chondromalacia lesions did not show changes in collagen, hydroxylysylpyridinoline and lysylpyridinoline concentration as compared with the controls. "
02/01/1998 - "To study the extracellular matrix alterations associated to chondromalacia, we determined the concentration of collagen (hydroxyproline) and its hydroxylysylpyridinoline and lysylpyridinoline crosslinks from chondromalacia foci of the patellae in 12 patients and 7 controls from apparently normal cadavers. "

01/01/1997 - "After 2 years, the results of the laser collective were significantly improved, whereas the results for the conventional collective, especially for chondromalacia and synovialitis, did not show the same improvement. "
03/01/1997 - "Therefore, laser treatment of chondromalacia cannot be recommended. "
03/01/1997 - "After laser treatment of local chondromalacia, large cartilage lesions with less tendency towards repair were more often seen than after conventional arthroscopic treatment. "
01/01/1991 - "A randomized, double blind study of low level laser treatment of chondromalacia of the patella in 40 patients has been undertaken. "
01/01/1990 - "One hundred and forty patients stage II or III chondromalacia according to Outerbridge were randomly assigned to arthroscopic operation using either laser or mechanical instruments. "

09/01/2010 - "Patients with symptomatic early-onset chondromalacia of the knee after ipsilateral meniscectomy will have improved clinical outcomes after meniscal transplantation. "
01/01/2014 - "The Autologous Chondrocytes Transplantation (ACT) method is being studied for repair of cartilage diseases. "
03/01/2009 - "Recently, cartilage diseases have been treated by auto- or allogenic chondrocyte transplantation. "
01/01/2010 - "Newer techniques that combine patellofemoral arthroplasty with autologous osteochondral transplantation or unicompartmental arthroplasty appear to be effective for patients with associated tibiofemoral chondromalacia."
10/06/1994 - "A mean of 36 months after transplantation, the results were excellent or good in two of the seven patients with patellar transplants, fair in three, and poor in two; two patients required a second operation because of severe chondromalacia. "

09/01/2013 - "To date, there are no published randomized controlled trials on the efficacy of use of autologous BMC intra-articular injections performed as a same-day in-office procedure for treating patients with cartilage disease; however, several publications have reported the ease of use of this method, its strong safety profile, and the fundamental science suggesting great therapeutic potential. "
09/01/2013 - "Current therapies for patients with cartilage disease or osteoarthritis range from non-surgical intra-articular injections with biologics, such as hyaluronic acid (HA), to total joint arthroplasty for advanced stages of disease. "

01/01/2002 - "We compared the effects of treatment with bipolar and monopolar radiofrequency energy on 30 osteochondral sections harvested from 22 patients with spontaneously occurring chondromalacia who were undergoing knee arthroplasty. "
11/01/1998 - "This article describes the results of treating temporomandibular joint (TMJ) articular disc perforation and advanced chondromalacia arthroscopically by the use of discoplasty and abrasion arthroplasty. "
11/01/1998 - "Arthroscopic management of temporomandibular joint disc perforations and associated advanced chondromalacia by discoplasty and abrasion arthroplasty: a supplemental report."
08/01/1994 - "Grade IV chondromalacia with exposed bone was treated by abrasion arthroplasty with the goal of resurfacing the bone with fibrocartilage. "
08/01/1994 - "Arthroscopic management of temporomandibular joint disc perforations and associated advanced chondromalacia by discoplasty and abrasion arthroplasty: preliminary results."

05/01/1989 - "The CO2 laser is especially effective in the "tight knee" for high surface area, low volume lesions, and chondromalacia. "