Carotid Body Tumor

An invariably benign, encapsulated, firm round mass at the bifurcation of the common carotid artery, with nests of large polyhedral cells in alveolar or organoid arrangement. It is usually asymptomatic but large masses may encroach upon the parapharyngeal space and produce dysphagia, pain, and cranial nerve palsies. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp570-71)

Also Known As:

Networked: 99 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Extra-Adrenal Paraganglioma (Paraganglioma, Extra Adrenal)
3.	Pheochromocytoma
4.	Paraganglioma (Paragangliomas)
5.	Neurilemmoma (Schwannoma)

Experts

1.	Karemaker, John M: 3 articles (06/2004 - 03/2002)
2.	Timmers, Henri J L M: 3 articles (06/2004 - 03/2002)
3.	Wieling, Wouter: 3 articles (06/2004 - 03/2002)
4.	Lenders, Jacques W M: 3 articles (06/2004 - 03/2002)
5.	Pacak, Karel: 2 articles (07/2014 - 07/2003)
6.	Jansen, Jeroen C: 2 articles (01/2012 - 01/2004)
7.	Marres, Henri A M: 2 articles (08/2003 - 03/2002)
8.	Chen, Wei-liang: 1 article (03/2015)
9.	Zhang, Da-ming: 1 article (03/2015)
10.	Tang, Qiong-lan: 1 article (03/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Carotid Body Tumor:

1.	Chromogranin AIBA 01/01/2014 - "A catecholamine-secreting carotid body paraganglioma (CSCBP) was suspected; the diagnosis was confirmed biochemically by determining plasma norepinephrine (NE) level, 89 000 pmol/l, and chromogranin A (CgA) level, 279 μg/l. " 09/25/1993 - "Nine extra-adrenal paragangliomas (three jugulo-tympanic, four carotid-body tumors, and two retroperitoneal) were studied by conventional histological criteria, and also by chromogranin A and neuron-specific enolase (NSE) immunohistochemical staining for the study of chief cells, and S-100 as a marker of sustentacular cells. " 02/01/1997 - "Plasma levels of chromogranin A were measured by enzyme-linked immunosorbent assay in 33 patients with prostatic carcinoma, 10 with benign prostatic hyperplasia (BPH) and 13 with neuroendocrine tumors (2 medullary thyroid carcinomas, 1 thymic carcinoid, 1 gastrin producing duodenal carcinoid, 3 nonfunctioning pancreatic endocrine tumors, 2 neuroblastomas, 3 pheochromocytomas and 1 carotid body tumor). "
2.	pentetreotide (OctreoScan)FDA Link 10/01/2009 - "Computed tomography (CT) and magnetic resonance imaging (MRA) angiographies are the preferred pre-operative diagnostic imaging investigations, as well as the 111 In-pentetreotide scintigraphic scan, whereas the standard ultrasound investigations have poor sensitivity in characterizing of the blood flows of the parenchimal structure of the carotid body tumors. " 05/01/1997 - "This study was conducted to investigate and illustrate the use of Indium In-111 pentetreotide scintigraphy as it applies to carotid body tumors (CBT). " 05/01/1997 - "Indium In-111 pentetreotide scintigraphy: application to carotid body tumors."
3.	Phosphopyruvate Hydratase (Enolase)IBA 09/25/1993 - "Nine extra-adrenal paragangliomas (three jugulo-tympanic, four carotid-body tumors, and two retroperitoneal) were studied by conventional histological criteria, and also by chromogranin A and neuron-specific enolase (NSE) immunohistochemical staining for the study of chief cells, and S-100 as a marker of sustentacular cells. "
4.	IndiumIBA 05/01/1997 - "This study was conducted to investigate and illustrate the use of Indium In-111 pentetreotide scintigraphy as it applies to carotid body tumors (CBT). " 05/01/1997 - "Indium In-111 pentetreotide scintigraphy: application to carotid body tumors."
5.	tebufenozide (Mimic)IBA 03/01/2011 - "It may mimic a carotid body tumor when it presents in the neck. " 03/01/2009 - "CSCSs are rare and known to mimic carotid body tumors. " 01/01/2012 - "Histopathologic examination showed that the excised tissue was a schwannoma, which in this location can mimic a carotid body tumor. " 01/01/2012 - "As this report demonstrates, the clinical and radiologic presentation of a hypoglossal schwannoma may closely mimic that of the more common carotid body tumor." 09/01/2007 - "These interesting tumors along with schwannomas in general and the remaining class of neurogenic tumors are known for their ability to mimic the physical and radiological findings of carotid body tumors. "
6.	DNA (Deoxyribonucleic Acid)IBA 05/01/2005 - "DNA testing was performed, for the first time in Greece, on patients with carotid body tumor. " 03/15/1992 - "Different DNA indices, including a double peak for the carotid body tumor, were obtained. " 12/01/1990 - "A case study of bilateral familial carotid body paragangliomas with DNA flow cytometric and cytogenetic analyses is presented. " 04/01/1990 - "The clinical and pathological features of 13 carotid body paragangliomas from 12 patients were examined and correlated with the DNA ploidy pattern as determined by image analysis. " 04/01/1990 - "From these observations, we conclude that abnormalities in DNA content of carotid body paragangliomas are common and that tumor ploidy cannot be used to assess malignant potential. "
7.	Succinate Dehydrogenase (Fumarate Reductase)IBA 01/01/2004 - "Carotid body tumors in humans caused by a mutation in the gene for succinate dehydrogenase D (SDHD)." 07/01/2014 - "Carotid body paragangliomas are rare tumors that often affect patients with genetic mutations of the succinate dehydrogenase complex (SDHx). " 12/01/2012 - "Based on 6 patients with 11 solitary (4 patients) and multiple (2 patients) HNP (8 carotid body tumors, 1 vagal, 1 jugular and 1 jugulotympanic paraganglioma) the specific characteristics of the need for surgery as well as correct choice of treatment in cases of sporadic succinate dehydrogenase (SDH) negative and hereditary SDH positive HNP will be exemplarily demonstrated. " 01/01/2012 - "We present a case of a female patient who presented in 2003 with bilateral carotid body tumors and a tympanic tumor, associated with a mutation in the succinate dehydrogenase -sub-unit-D (SDHD). "
8.	3-Iodobenzylguanidine (Iobenguane)IBA 06/01/1994 - "Carotid body tumor masked by salivary gland uptake on I-123 MIBG scintigraphy." 04/01/1987 - "In the first case, with multicentric and locally invasive disease, [131I]MIBG correctly localized a right carotid body paraganglioma which had been missed arteriographically. " 07/01/1991 - "Chemodectomas (carotid body tumors) were surgically removed on two occasions, first 10 years and then 3 months prior to detection with I-131 MIBG of an adrenal pheochromocytoma in a 32-year-old man with a family history of chemodectoma. "
9.	Octreotide (Sandostatin)FDA LinkGeneric 11/01/2014 - "We describe the case of a patient with bilateral carotid body tumor who underwent a preoperative ⁶⁸Gallium labeled [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-1-NaI3-Octreotide (⁶⁸Ga-DOTANOC) positron emission tomography/computed tomography (PET/CT) imaging for staging. " 01/01/2014 - "Catecholamine-secreting carotid body paraganglioma: successful preoperative control of hypertension and clinical symptoms using high-dose long-acting octreotide." 01/01/2010 - "Magnetic resonance imaging (MRI), 99mTc-labeled octreotide scan and angiography diagnosed the swellings as carotid body paraganglioma, stage III on the right side with left-sided vagal malignant paraganglioma. "
10.	EnbucrilateIBA 02/01/2011 - "We report two cases of carotid body tumor treated with direct puncture and intratumoral injection of N-butyl cyanoacrylate glue (NBCA) assisted with balloon protection technique for preoperative devascularization. " 02/01/2011 - "Preoperative embolization of carotid body tumor by direct percutaneous intratumoral injection of N-butyl cyanoacrylate glue assisted with balloon protection technique." 05/01/2007 - "A 52-year-old male with right carotid body tumor underwent direct percutaneous glue (n-butylcyanoacrylate [NBCA]) embolization. " 10/01/2004 - "We report ultrasound-guided direct percutaneous injection of n-butyl cyanoacrylate for preoperative embolization of carotid body tumor in a 50-year-old patient. " 10/01/2004 - "Direct percutaneous embolization of a carotid body tumor with n-butyl cyanoacrylate: an alternative method to endovascular embolization."

Therapies and Procedures

1.	Radiotherapy 01/01/2012 - "This is the first report demonstrating the efficacy of radiotherapy for both biochemical and locoregional control of functioning carotid body paragangliomas." 01/01/2014 - "Carotid body paragangliomas: a systematic study on management with surgery and radiotherapy." 01/01/2012 - "Carotid body tumors: radiotherapy as an alternative approach." 01/01/2014 - "It is caused by history of trauma or radiotherapy in the cervical legion, bilateral carotid-body tumor or resection of glossopharyngeal nerve. " 08/01/2000 - "Radiotherapy as adjunct to surgery for malignant carotid body paragangliomas presenting with lymph node metastases."
2.	Balloon Occlusion 07/01/1993 - "One patient had undergone balloon occlusion of the internal carotid artery; in the other patient, embolization of a carotid body tumor had been performed. " 11/01/2013 - "Our study results suggest that (i) carotid body tumors should be handled with multidisciplinary approach; (ii) balloon occlusion test should be performed in all patients undergoing surgery; (iii) a particular attention should be paid to cranial and phrenic nerves, if it is necessary to extend the surgical field while removing the tumor; and (iv) pathological examination should be carried out by an experienced team and in a multi-centered fashion, if necessary." 08/01/2002 - "We report on the preoperative embolization of a carotid-body paraganglioma by temporary balloon occlusion and ethanol injection. " 08/01/2002 - "Temporary balloon occlusion and ethanol injection for preoperative embolization of carotid-body tumor."
3.	Transplants (Transplant) 11/01/2004 - "In those cases where the carotid body tumor involves the internal carotid artery to the point that its sacrifice is imminent and synthetic grafts are not available, reconstruction of the internal carotid artery with transposition of the external carotid artery is recommended." 09/01/1978 - "Surgeons removing carotid body tumors should be experienced in arterial wall repair by means of vascular shunts, end-to-end arterial anastomosis, and vein graft replacement of a segment of arterial wall." 09/01/1969 - "Excision of malignant carotid body tumor: resection of carotid bifurcation with autogenous vein graft." 08/01/1962 - "Carotid body tumor, its recognition, resection, and replacement by arterial graft." 11/01/2004 - "The current treatment of Shamblin's class III carotid body tumors includes a variety of reconstructive techniques for the internal carotid artery, ranging from angioplasty to the use of various grafts such as autologous saphenous vein or synthetic shunts. "
4.	Ligation 02/01/2013 - "We describe a 34-year-old woman who underwent left ICA ligation during a large carotid body tumor surgery. " 08/01/2010 - "All cases of carotid body tumor were resected without any carotid artery ligation. " 03/01/2015 - "Tumor size ranged from 2 × 3 to 5 × 6 (median, 3.7 × 4.7) cm. Two patients underwent blunt dissection of the carotid body tumor, two underwent blunt dissection and ligation of the external carotid artery of the carotid body tumor, and two patients had common carotid artery-internal carotid artery artificial vascular reconstruction. " 02/01/2013 - "This report describes a case of a delayed cerebral embolic infarction, after internal carotid artery (ICA) ligation secondary to carotid body tumor resection. " 02/01/2013 - "Embolic stroke after carotid artery ligation during carotid body tumor resection."
5.	Denervation 11/01/2010 - "Baroreceptor failure syndrome is a rare and important complication known to be associated with many conditions, one of them being inadvertent baroreceptor denervation during bilateral carotid body tumor resection. " 06/01/2004 - "Iatrogenic bilateral denervation of carotid sinus baroreceptors may occur as a complication of carotid body tumor resection and radiation therapy of the neck. " 08/01/2003 - "Denervation of carotid sinus baroreceptors as the result of bilateral carotid body tumor resection produces chronic impairment of baroreflex control of both heart rate and sympathetic nerve activity. " 03/19/2002 - "Acute carotid sinus denervation, as a result of bilateral carotid body tumor resection, has a long-term effect on the level, variability, and rapid reflex control of arterial BP. Therefore, in contrast to earlier experimental observations, the compensatory ability of the baroreceptor areas outside the carotid sinus seems to be of limited importance in the regulation of BP in humans." 03/19/2002 - "We studied 4 women (age 41 to 63 years) who were referred for evaluation of arterial baroreflex function because of clinical suspicion of carotid sinus denervation attributable to bilateral carotid body tumor resection. "