Carotenoids (Carotene)

The general name for a group of fat-soluble pigments found in green, yellow, and leafy vegetables, and yellow fruits. They are aliphatic hydrocarbons consisting of a polyisoprene backbone.

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Networked: 1934 relevant articles (106 outcomes, 406 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Willett, Walter C: 22 articles (12/2015 - 03/2002)
2.	Albanes, Demetrius: 19 articles (11/2015 - 09/2002)
3.	Semba, Richard D: 17 articles (08/2015 - 09/2002)
4.	Suzuki, Koji: 17 articles (01/2013 - 07/2002)
5.	Mares, Julie A: 16 articles (11/2015 - 02/2004)
6.	Ito, Yoshinori: 16 articles (01/2013 - 07/2002)
7.	Virtamo, Jarmo: 15 articles (07/2014 - 09/2002)
8.	Neuhouser, Marian L: 13 articles (11/2015 - 06/2007)
9.	Bernstein, Paul S: 13 articles (10/2014 - 10/2002)
10.	Johnson, Elizabeth J: 13 articles (01/2014 - 03/2002)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2001 - "Many epidemiologic studies have shown strong associations between diets rich in carotenoids and a reduced incidence of many forms of cancer, and that finding led to the suggestion that the antioxidant properties of those compounds might help protect immune cells from oxidative damage, thus enhancing their ability to detect and eliminate tumor cells. " 12/01/1998 - "Studies on tumour cells indicate that carotenoids can interfere with the growth of transformed cells, suggesting that they may be effective in the treatment of some cancers." 09/01/2005 - "Carotenoids have been implicated in numerous epidemiological studies as being protective against cancer at many sites, and their chemopreventive properties have been confirmed in laboratory studies. " 07/01/2000 - "Over the last few years, carotenoids have been studied extensively for their antioxidant activity and the supposed protective effects against cancer, in particular those of the digestive tract. " 08/01/1999 - "Many epidemiological studies have shown an association between diets rich in carotenoids and a reduced incidence of many forms of cancer, and it has been suggested that the antioxidant properties of these compounds are a causative factor. "
2.	Lung Neoplasms (Lung Cancer) 12/01/1990 - "Higher intake of carotene-rich vegetables was not protective against lung cancer in this population. " 05/01/2011 - "Clinical trials of β-carotene supplementation and recent large-scale prospective studies have called into question the protective effects of vegetable and fruit consumption against lung cancer. " 01/01/2015 - "Evidence from 18 studies suggested that higher category of dietary β-carotene intake could reduce lung cancer risk (0.768 (0.675-0.874)).The associations were also significant in American and Asian populations. " 01/01/2015 - "The aim of this study was to compare the dietary intake and serum levels of some selected carotenoids of lung cancer patients with healthy subjects. " 10/01/2011 - "However, two human intervention trials conducted in Finland and in the United States have reported contrasting results with high doses of β-carotene supplementation increasing the risk of lung cancer among smokers. "
3.	Cardiovascular Diseases (Cardiovascular Disease) 06/19/2001 - "Carotenoids are hypothesized to explain some of the protective effects of fruit and vegetable intake on risk of cardiovascular disease. " 02/01/2006 - "More recent studies have focused on individual carotenoids in relation to cardiovascular disease and require a more careful evaluation of potential mechanisms of effect. " 01/01/2013 - "Several epidemiologic studies have reported an inverse association between serum levels of carotenoids and cardiovascular disease risk. " 01/01/2013 - "In addition, low serum β-carotene concentrations increased the risk of cardiovascular disease (CVD) and total mortality. " 10/01/2012 - "Low β-carotene concentrations increase the risk of cardiovascular disease mortality among Finnish men with risk factors."
4.	Atherosclerosis 01/01/2013 - "The present study shows that high serum concentrations of carotenoids may be protective against early atherosclerosis." 01/01/2013 - "Several previous epidemiologic studies have shown that high blood levels of carotenoids may be protective against early atherosclerosis, but results have been inconsistent. " 02/01/2004 - "Recent epidemiologic and animal model data suggest that oxygenated carotenoids are protective against early atherosclerosis. " 06/01/1992 - "Consumption of carotenoids is associated with an enhanced immune response and protection against neoplasia and atherosclerosis. " 01/01/2013 - "The results of this study suggest that a diet containing natural carotenoids, rich in 9-cis-β-carotene, has the potential to inhibit atherosclerosis progression, particularly in high-fat diet regime."
5.	Chronic Disease (Chronic Diseases) 01/01/2013 - "Through this study a definite dosage formulation for consumption of carotenoids is being proposed which will enhance health promotion and prevent chronic diseases when taken as fortified foods or dietary supplements. " 01/01/2007 - "This study reveals the importance of a continuous consumption of carotenoid rich foods in order to maintain high levels of plasma carotenoids for the potential prevention of chronic diseases in individuals." 12/05/2002 - "The analysis of carotenoids in plasma, foods and tissues has thus become of interest in studies examining the role of diet in chronic disease prevention and management. " 12/05/2002 - "Epidemiologic and clinical studies have shown that a high intake of vegetables and fruit, with consequently high intakes and circulating concentrations of carotenoids, is associated with reduced risk of cardiovascular and other chronic diseases. " 05/01/1996 - "Numerous observational studies have found that people who ingest more carotenoids in their diets have a reduced risk of several chronic diseases. "

Related Drugs and Biologics

1.	Vitamins
2.	beta Carotene (Betacarotene)
3.	Ascorbic Acid (Vitamin C)
4.	Vitamin E
5.	Vitamin A (Retinol)
6.	Antioxidants
7.	polyphenols
8.	Lutein
9.	lycopene
10.	zeaxanthin

Related Therapies and Procedures

1.	Chemoprevention
2.	Fat-Restricted Diet (Diet, Fat Restricted)
3.	Drug Therapy (Chemotherapy)
4.	Caloric Restriction
5.	Dye Lasers