Carnosine

10/10/2015 - "L-carnosine-phospholipid complex could be a promising approach for effective delivery to the human lens as offers a potential novel treatment for senile cataract."
11/26/2014 - "Therefore, carnosine is effective in preserving the structural integrity of the protein, suggesting the possibility of new strategies of intervention for preventing or treating pathologies related to protein aggregation, like cataracts. "
09/01/2006 - "To determine the efficacy of a topical antioxidant formulation including N-acetyl carnosine in the treatment of canine cataract in a preliminary nonplacebo, controlled, unmasked study. "
01/01/2009 - "To compare the efficacy of L-carnosine and derivatives in inhibiting/reversing oxidative stress-induced reactions relevant for cataract pathogenesis. "
10/10/2015 - "This study presents a simple but sensitive HPLC chromatographic method with a stability-indicating assay for determination and physicochemical characterisation of L-carnosine, a promising senile cataract prophylactic agent. "

03/01/2002 - "Administration of carnosine (10 mg/day) for 15 days either concurrent with infection, 2 and 4 weeks post-infestation was effective in reducing differential worm burden. "
08/01/2000 - "Administration of carnosine (10 mg/day) for 15 days either concurrent with infection, 2 and 4 weeks post exposure was effective in reducing worm burden and egg count only when given at the time of infection. "
05/01/2001 - "Administration of carnosine (10 mg/day) for 15 days concurrent with infection effectively reduced worm burden and egg count. "
01/01/2012 - "The developed and patented by the authors formulations of nonhydrolized in digestive tract and blood natural carnosine peptide and isopeptide (gamma-glutamyl-carnosine) products have a promise in the Influenza A (H1N1) virus infection disease control and prevention."
10/01/1968 - "Homocarnosine and carnosine have been identified in bovine brain extracts which are effective in protecting mice against infections by Staphylococcus aureus. "

07/01/2000 - "In experimental cerebral ischemia, carnosine decreases mortality and is beneficial for neurological conditions of the animals. "
11/01/2007 - "We investigated the efficacy of carnosine in a mouse model of permanent focal cerebral ischemia. "
04/24/2013 - "Considerable studies have showed that L-carnosine provides anti-oxidative and anti-apoptotic roles in the animal models of global or focal cerebral ischemia. "
11/01/2007 - "The purposes of this study were to determine whether carnosine is neuroprotective in permanent focal cerebral ischemia and to determine potential mechanisms of neuroprotection. "
04/24/2013 - "These results indicate that L-carnosine plays an important role in inhibiting neuronal cell apoptosis through STAT3 signaling pathway after acute cerebral ischemia."

01/01/2008 - "Ageing is associated with a significant reduction in skeletal muscle carnosine which has been linked with a reduction in the buffering capacity of muscle and in theory, may increase the rate of fatigue during exercise. "
02/01/2014 - "There are moderate to high quality studies that appear to support that BA may increase power output and working capacity, decrease the feeling of fatigue and exhaustion, and have of positive effect on body composition and carnosine content. "
03/01/2015 - "Changes in muscle carnosine content was correlated to changes in fatigue rate (r = 0.633, p = 0.06). "
02/01/2009 - "In conclusion, HIIT appeared to be the primary stimulus effecting EMG(FT) or EEA, suggesting adaptations from HIIT may be more influential than increasing skeletal muscle carnosine levels on delaying fatigue in recreationally active men."
01/01/1986 - "It was shown that the previously described phenomenon of fatigue elimination by carnosine addition to the Ringer solution washing the muscle is concomitant with the elevation (by 12%) of the intramuscular concentration of exogenous carnosine."

01/01/2009 - "Physiologically carnosine may help to suppress some secondary complications of diabetes, and the deleterious consequences of ischemic-reperfusion injury, most likely due to antioxidation and carbonyl-scavenging functions. "
06/01/2014 - "Carnosine may be an endogenous regulator of astrocyte energy metabolism and a clinically safe therapeutic agent for promoting brain energy metabolism recovery after ischemia/reperfusion injury."
10/01/2005 - "Carnosine, a specific constituent of excitable tissues of vertebrates, exhibits a significant antioxidant protecting effect on the brain damaged by ischemic-reperfusion injury when it was administered to the animals before ischemic episode. "
08/01/2012 - "In vivo evaluation of organ protection in a model of cerebral ischaemia/reperfusion injury, using the selected NO-donor 7e and its des-NO analogue 7a, showed that both derivatives protect from hypoxia-induced brain damage, at lower concentrations than carnosine; 7e also decreased serum TNF-α levels. "
09/01/1992 - "[Reperfusion injury of myocardial biomembranes after acute fatal hemorrhage and their correction with carnosine]."