Carnitine (L-Carnitine)

09/01/2006 - "The results suggest that L-carnitine provides marked protection against ischemia-reperfusion-related gastric injury which could be due to its ability to reduce neutrophil accumulation in ischemic tissue."
01/01/2001 - "Coronary blood flow and myocardial oxygen consumption were significantly improved after ischemia in the carnitine group compared with the control group (p < 0.05). "
01/01/2001 - "Carnitine significantly improved not only LV systolic function but also LV diastolic function (p < 0.05) as well as LV compliance after ischemia. "
04/01/1984 - "In another experiment, L-carnitine administration (750 mg/kg/d for 14 days) significantly improved the recovery of cardiac output after 60, 90, and 120 minutes of ischemia in diabetic perfused hearts. "
01/01/2007 - "In addition, l-carnitine seemed to be more effective with regard to decreasing lipid peroxidation in liver tissue when administered before warm hepatic ischemia. "

01/01/2003 - "In contrast, patients treated with IFN + carnitine show a marked and early significant reduction of fatigue levels. "
01/01/2013 - "Carnitine group showed significant improvement in maximum fused tetanic tension, maximum fused tetanic tension after fatigue protocol and recovery from fatigue after 5 minutes of rest period compared to the diabetic group. "
04/01/2009 - "However, an exploratory covariate analysis that excluded these two protocol violators and included outcome data from both the double-blind and open-label phases demonstrated significantly improved fatigue on the FACT-An fatigue subscale (P<0.03), and significantly improved FACT-An functional well-being subscale (P<0.03), and KPS (P<0.003), in the group that started with L-carnitine during the double-blind phase. "
05/01/2001 - "L-Carnitine significantly improved the fatigue domain of the KDQ after 12 (P = 0.01) and 24 weeks (P = 0.03) of treatment compared with placebo using the primary analysis but did not significantly affect the total score (P = 0.10) or other domains of the instrument (P > 0.11). "
01/01/2014 - "L-carnitine ameliorated fasting-induced fatigue, hunger, and metabolic abnormalities in patients with metabolic syndrome: a randomized controlled study."

09/01/1987 - "This is the first study demonstrating that high-dose L-carnitine treatment results in improved cardiac performance and increased myocardial total high-energy phosphate stores in the Syrian hamster model with one of two distinct forms of cardiomyopathy, i.e., dilated or hypertrophic. "
01/01/1987 - "Protective effects of carnitine have been described in different myocardial diseases. "
12/01/2002 - "Her health improved with resolving cardiomyopathy after the use of L-carnitine (50-100 mg/kg/day). "
12/01/2000 - "Cardiomyopathy was not improved by carnitine therapy. "
01/06/1989 - "Patients with cardiomyopathy due to carnitine loss are cured by carnitine supplementation. "

01/01/2012 - "However, carnitine did not exert protective effects on intestinal tumors in Apc (Min/+) mice."
12/01/2011 - "Carnitine administration reduces cytokine levels, improves food intake, and ameliorates body composition in tumor-bearing rats."
07/15/2011 - "In the present study, we aim to assess the effects of L-carnitine on the activity and expression of CPT I and II in the liver of cachectic cancer mice. "
04/01/2009 - "However, L-carnitine supplementation does increase L-carnitine serum levels, and the positive findings in an exploratory analysis justify a larger study to determine if this strategy could be of benefit for a subpopulation of cancer patients."
02/01/2009 - "This study shows the effects of L-carnitine treatment on cell proliferation with hepa1c1c7 mouse cancer cells and NCTC 1469 normal cells. "

09/01/1992 - "Controlled study on the therapeutic efficacy of propionyl-L-carnitine in patients with congestive heart failure."
04/01/1988 - "Evaluation of the therapeutic efficacy of L-carnitine in congestive heart failure."
02/01/2000 - "The ongoing CEDIM-2 trial (projected 4000 patients with acute MI) will assess the efficacy of L-carnitine in reducing the combined incidence of death and heart failure at 6 months. "
06/01/2013 - "To observe the efficacy of levocarnitine in treating elderly patients with chronic heart failure and to explore its impact on cardiac function and endocrine. "
09/01/2013 - "The aim of this study was to investigate carnitine metabolism in relation to progression of heart failure (HF). "