Cardiotonic Agents (Cardiac Stimulants)

Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).

Also Known As:

Cardiac Stimulants; Cardiotonic Drugs; Cardiotonics; Agent, Cardioprotective; Agent, Cardiotonic; Drug, Cardiotonic; Stimulant, Cardiac; Stimulant, Myocardial; Cardiac Stimulant; Cardioprotective Agent; Cardioprotective Agents; Cardiotonic; Cardiotonic Agent; Cardiotonic Drug; Inotropic Agents, Positive Cardiac; Myocardial Stimulant; Myocardial Stimulants

Networked: 681 relevant articles (50 outcomes, 75 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Therapeutic Uses: 47080
    - Cardiovascular Agents: 817
      - Cardiotonic Agents: 681
- Specialty Uses of Chemicals
  - Protective Agents: 1384
    - Cardiotonic Agents: 681

Experts

1.	Han, Jing-Yan: 7 articles (01/2019 - 01/2005)
2.	Fan, Jing-Yu: 6 articles (01/2019 - 01/2006)
3.	Sun, Kai: 6 articles (01/2019 - 01/2006)
4.	Liu, Yu-Ying: 5 articles (01/2013 - 01/2006)
5.	Chang, Xin: 4 articles (01/2019 - 04/2010)
6.	Hu, Bai-He: 4 articles (01/2019 - 04/2010)
7.	Wang, Chuan-She: 4 articles (01/2013 - 01/2006)
8.	Latchman, D S: 4 articles (05/2005 - 03/2000)
9.	Pan, Chun-Shui: 3 articles (01/2019 - 04/2010)
10.	Mathur, Anthony: 3 articles (01/2017 - 11/2015)

Related Diseases

1.	Heart Failure 05/01/1988 - "Its effectiveness and lack of significant toxicity make it beneficial for clinical use as a cardiotonic in human heart failure. " 08/01/1987 - "The therapeutic efficacy of cardiotonic drugs used in the treatment of ambulant heart failure patients should be evaluated with reference to the way they alter the relation between cardiac pumping reserve and exercise capacity." 11/01/1984 - "Cardiotonic agents may prove useful in the long-term treatment of chronic heart failure provided myocardial efficiency is enhanced and clinical status is improved. " 12/01/1989 - ""Cardiotonic Drugs in the Management of Chronic Congestive Heart Failure: Digitalis Revisited "." 04/01/1982 - "Cardiotonic agents in the management of chronic cardiac failure."
2.	Cardiotoxicity 04/17/2008 - "These findings suggest that butanolic fraction of Terminalia arjuna bark has protective effects against Dox-induced cardiotoxicity and may have potential as a cardioprotective agent." 10/18/2023 - "Our study demonstrates the utility of hPCMs in the detection of clinically relevant cardiac toxicities, and offers a framework for hPCM-based high-throughput screening of cardioprotective agents." 01/01/2021 - "Methods and Results Three databases (CENTRAL, MEDLINE, and SCOPUS) were systematically searched for randomized trials evaluating cardioprotective agents against placebo, in preventing cardiotoxicity. " 09/01/2023 - "Gal may serve as a promising cardioprotective agent for DOX-induced cardiotoxicity." 12/05/2022 - "Therefore, looking for effective cardioprotective agent to avoid the occurrence of drug-induced cardiotoxicity has become a great challenge for many researchers. "
3.	Neoplasms (Cancer) 03/24/2023 - "High-dose DFO (50 mg/kg) may serve as a promising cardioprotective agent at least at the molecular level in cancer patients treated with DOX. " 02/01/2018 - "Therefore, hA3AR modulators, and in particular agonists, are sought for their potential application as anti-inflammatory, anti-cancer and cardioprotective agents. " 01/01/2011 - "To the best of our knowledge, Sch B is the only molecule ever proved to function as a cardioprotective agent as well as a chemotherapeutic sensitizer, which is potentially applicable for cancer treatment." 07/01/2019 - "In the past it was used to produce cardiotonic medicine and there are studies on using this plant as an anti-cancer medicine and on its use in alternative medicine for many causes. " 01/24/2018 - "Cortex Periplocae is a well-known form of traditional medicine with its unique cardiotonic action, anti-tumor activity and immune regulation effect. "
4.	Fibrosis (Cirrhosis) 11/01/2022 - "The present study was to explore the role of compound Chinese medicine Cardiotonic Pills® (CP) in attenuating ISR-evoked myocardial injury and fibrosis. " 01/01/2013 - "Investigation of the molecular and cellular bases of organ fibrosis, including the factors of dysregulated activation, differentiation and survival of microfibroblasts, makes it possible to specify the mechanisms of action of traditional nephro- and cardioprotective agents, to offer a possibility for a goal-oriented (target) effect on individual fibrogenic components, and to expand the arsenal of medications suppressing renal and cardiac remodeling." 11/01/2022 - "Cardiotonic Pills® protects from myocardial fibrosis caused by in stent restenosis in miniature pigs." 03/01/2017 - "The current study demonstrated for the first time that L7DG is pharmacologically effective in protecting the heart against developing ISO-induced injury and fibrosis, justifying further evaluation of L7DG as a cardioprotective agent to treat related cardiovascular diseases." 01/01/2013 - "Treatment with cardiotonic pills(®) after ischemia-reperfusion ameliorates myocardial fibrosis in rats."
5.	Ischemia 06/13/2012 - "One of the possible reasons for the discrepancy between the results of animal experiments and clinical trials is that co-morbidities, including DM, modified myocardial responses to ischemia/reperfusion and to cardioprotective agents. " 01/01/2022 - "Δ9-Tetrahydrocannabinol (Δ9-THC) Improves Ischemia/Reperfusion Heart Dysfunction and Might Serve as a Cardioprotective Agent in the Future Treatment." 02/01/2017 - "It has been shown that diabetes modifies the myocardial responses to ischemia/reperfusion (I/R) and to cardioprotective agents. " 04/01/2010 - "Cardiotonic pills, a compound Chinese medicine, protects ischemia-reperfusion-induced microcirculatory disturbance and myocardial damage in rats." 10/01/2003 - "Cardiotonic agents may differentially alter indices of the cytosolic [Ca2+]/left ventricular pressure (LVP) relationship when given before and after ischemia. "

Related Drugs and Biologics

1.	Anthracyclines
2.	Dexrazoxane (Zinecard)
3.	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)
4.	Vasodilator Agents (Vasodilators)
5.	Isoproterenol (Isoprenaline)
6.	MCI 154
7.	Diuretics
8.	Dobutamine
9.	Cardiac Glycosides
10.	sulmazole (Vardax)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Resuscitation
4.	Skin Transplantation (Skin Grafting)
5.	Mechanical Ventilators (Ventilator)