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Dilated Cardiomyopathy (Cardiomyopathy, Congestive)

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A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.

Also Known As:

Cardiomyopathy, Congestive; Cardiomyopathy, Dilated; Cardiomyopathy, Dilated, CMD1A; Cardiomyopathy, Dilated, LMNA; Cardiomyopathy, Dilated, with Conduction Deffect1; Cardiomyopathy, Familial Idiopathic; Cardiomyopathies, Congestive; Cardiomyopathies, Dilated; Cardiomyopathies, Familial Idiopathic; Congestive Cardiomyopathies; Dilated Cardiomyopathies; Familial Idiopathic Cardiomyopathies; Familial Idiopathic Cardiomyopathy; Idiopathic Cardiomyopathies, Familial; Idiopathic Cardiomyopathy, Familial; Congestive Cardiomyopathy

Networked: 5503 relevant articles (265 outcomes, 656 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Heart Failure
2.	Myocarditis (Carditis)
3.	Hypertension (High Blood Pressure)
4.	Fibrosis (Cirrhosis)
5.	Atrial Fibrillation

Experts

1.	Towbin, Jeffrey A: 24 articles (02/2015 - 03/2002)
2.	Watanabe, Kenichi: 23 articles (07/2015 - 04/2002)
3.	Kodama, Makoto: 23 articles (10/2012 - 04/2002)
4.	Hetzer, Roland: 21 articles (05/2015 - 01/2002)
5.	Felix, Stephan B: 21 articles (02/2015 - 02/2002)
6.	Seidman, J G: 20 articles (11/2015 - 12/2000)
7.	Maisch, Bernhard: 20 articles (04/2014 - 03/2002)
8.	Wallukat, Gerd: 19 articles (05/2015 - 02/2002)
9.	Schultheiss, Heinz-Peter: 19 articles (04/2015 - 06/2002)
10.	Katus, Hugo A: 19 articles (03/2015 - 01/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Dilated Cardiomyopathy:

1.	carvedilol (Coreg)FDA LinkGeneric 07/01/2009 - "The results of the present study indicate that carvedilol is well tolerated in children with dilated cardiomyopathy and there is a significant improvement in the clinical status and left ventricular ejection fraction in patients not responding to conventional therapy. " 01/01/2001 - "Carvedilol is well tolerated in infants with dilated cardiomyopathy and there is significant improvement in their functional status. " 08/01/2000 - "Notably, by the end of the first month of treatment, the antiarrhythmic efficacy of the drug was significantly greater in patients with ischaemic than in those with idiopathic dilated cardiomyopathy, an effect that could probably be attributed to the anti-ischaemic properties of carvedilol. " 08/01/2000 - "Efficacy of carvedilol on complex ventricular arrhythmias in dilated cardiomyopathy: double-blind, randomized, placebo-controlled study." 03/01/2007 - "In conclusion, carvedilol therapy is associated with improvement in both LV and LA functions in nonischemic dilated cardiomyopathy. "
2.	Metoprolol (Lopressor)FDA LinkGeneric 02/01/2001 - "In idiopathic dilated cardiomyopathy, the more significant improvement in symptoms and left ventricular function and size, that is observed following treatment using metoprolol, translates into a better outcome. " 05/01/1994 - "Metoprolol improved hemodynamic status in patients with dilated cardiomyopathy at rest and had a more pronounced effect during exercise. " 12/04/1997 - "Improvement in symptom score was reported in the Metoprolol in Dilated Cardiomyopathy (MDC) trial far patients treated with metoprolol. " 05/01/1993 - "This study thus provides evidence that long-term metoprolol therapy for dilated cardiomyopathy is associated with beta-receptor up-regulation, and the restoration of myocardial beta-receptor density may be associated with the improved cardiac function as determined by echocardiography." 09/01/1985 - "Improvement in symptoms and exercise tolerance by metoprolol in patients with dilated cardiomyopathy: a double-blind, randomized, placebo-controlled trial."
3.	Dobutamine FDA LinkGeneric 08/20/2013 - "Prediction of improvement in cardiac function by high dose dobutamine stress echocardiography in patients with recent onset idiopathic dilated cardiomyopathy." 09/01/2002 - "[Is intermittent dobutamine treatment beneficial in patients with dilated cardiomyopathy?]." 08/01/2001 - "Analysis of transseptal variation IB during dobutamine may provide useful information predicting the efficacy of beta-blocker therapy in dilated cardiomyopathy." 05/01/2008 - "These observations were made in 11 patients with idiopathic dilated cardiomyopathy treated in a single cardiology practice, who had evidence of myocardial "viability" (dysfunctional but noncontractile myocardium that has the potential for improvement in function) as assessed by cardiac magnetic resonance imaging, low-dose dobutamine echocardiography, or nuclear imaging. " 11/01/1980 - "Dobutamine is a new inotropic agent that may induce prolonged clinical improvement in patients with congestive cardiomyopathy. "
4.	Amiodarone (Amiodarona)FDA LinkGeneric 03/01/1987 - "Complex ventricular arrhythmias are frequent in dilated cardiomyopathy and it is suggested that amiodarone is effective in short- and long-term control of these arrhythmias." 03/01/2004 - "Efficacy of amiodarone treatment on cardiac symptom, function, and sympathetic nerve activity in patients with dilated cardiomyopathy: comparison with beta-blocker therapy." 03/01/1987 - "Ventricular arrhythmias in dilated cardiomyopathy: efficacy of amiodarone." 05/10/1998 - "The objective of this study was to assess the features of the new index and then to prospectively evaluate the effect of chronic amiodarone treatment on left ventricular function using the new index and standard methods in dilated cardiomyopathy. " 04/01/2013 - "In univariate analysis, amiodarone therapy, dilated cardiomyopathy, and lower ejection fraction were predictors of failure. "
5.	Digoxin (Digitek)FDA LinkGeneric 01/01/1996 - "To investigate whether measuring levels of digoxin in patients with idiopathic dilated cardiomyopathy (IDC) is helpful in dose adjustment of digoxin we did the following study. " 05/01/1990 - "Efficacy of digoxin for treatment of cats with dilated cardiomyopathy." 01/15/1985 - "Efficacy of digoxin administration in dogs with idiopathic congestive cardiomyopathy." 09/01/1991 - "In spite of symptomatic improvement, no study has demonstrated an unequivocal favorable effect of digoxin on survival of patients with dilated cardiomyopathy. " 06/01/2011 - "Dilated cardiomyopathy and potentially deadly digoxin."
6.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 10/01/2002 - "The present study examined the effect of treatment with angiotensin-converting enzyme inhibitors (ACEIs) on the long-term prognosis in 119 patients with dilated cardiomyopathy (DCM). " 09/01/2009 - "Angiotensin converting enzyme inhibitors (ACEIs) are recommended in people to treat asymptomatic (occult) dilated cardiomyopathy (DCM). " 04/01/1995 - "Angiotensin-converting enzyme inhibitors and beta-blockers in long-term treatment of dilated cardiomyopathy." 01/01/1995 - "The results indicate that treatment with angiotensin-converting enzyme inhibitors partly restores myocardial beta 1-adrenoceptor density, and this action effect may contribute to the clinical improvement of patients with idiopathic dilated cardiomyopathy treated in this way." 01/01/1994 - "Angiotensin-converting enzyme inhibitors appear to improve survival in dilated cardiomyopathy. "
7.	DiureticsIBA 06/01/1985 - "Accordingly, the prognosis of dilated cardiomyopathy might be improved by diuretics. " 09/01/2002 - "A 54-year-old man with dilated cardiomyopathy treated with diuretics, alpha-beta blockers, antiarrhythmics for the previous 5 years, had the indication for biventricular pacing and was scheduled for placing of pacing leads in his left ventricular wall under video-assisted thoracic surgery. " 06/01/1985 - "Diuretics are helpful in the treatment of congestive heart failure associated with dilated cardiomyopathy. " 11/01/2010 - "Patients with higher P-LCR were older (P = 0.038), with larger prevalence of diabetes (P < 0.0001), dilated cardiomyopathy or valvular heart disease (P = 0.004) and less often family history of CAD (P = 0.045), more often on statins (P = 0.002), and diuretics (P = 0.016). " 01/01/2010 - "Patients with higher PDW were older (p = 0.012), with higher weight (p < 0.0001) and waist (p < 0.0001), larger prevalence of diabetes (p = 0.014), dilated cardiomyopathy or valvular heart disease (p < 0.0001) and less often family history of CAD (p = 0.021), more often on statins (p = 0.005), and diuretics (p = 0.016). "
8.	Carnitine (L-Carnitine)FDA LinkGeneric 09/01/2005 - "LV mass/BSA decreased (164.29 g/m2+/-28.14 to 110.88 g/m2+/-28.88), but without significance (p = 0.089) In children with idiopathic dilated cardiomyopathy, supplementation of L-carnitine may be helpful for nutritional and echocardiographic improvement." 01/01/1998 - "It was concluded that L-carnitine therapy in children with idiopathic dilated cardiomyopathy led to modest improvement in left ventricular function." 12/01/1994 - "Case report: efficacy of oral carnitine therapy for dilated cardiomyopathy in boxer dogs." 04/01/2014 - "Primary carnitine deficiency is a cause of dilated cardiomyopathy in child. " 04/01/2014 - "The aim of this case report was to show the importance to research metabolic etiology, especially a carnitine deficiency in dilated cardiomyopathy of children. "
9.	3-Iodobenzylguanidine (Iobenguane)IBA 11/01/1997 - "The myocardial clearance and the heart to upper mediastinal ratio of I-123 MIBG scintigraphy were useful in evaluating the efficacy of long-term beta-blocker therapy in patients with dilated cardiomyopathy." 05/01/2005 - "Dilated cardiomyopathy relieved as a result of beta-blocker therapy: a case report--key points in assessment of prognosis based on MIBG myocardial scintigraphy and BNP levels." 07/01/2011 - "The aim of this study was to evaluate long-term prognosis in a roughly 10-year period, in dilated cardiomyopathy (DCM) by MIBG imaging, compared to other conventional functional parameters. " 11/01/2008 - "The purpose of the study is to examine prognostic values of cardiac I-123 metaiodobenzylguanidine (MIBG) uptake and cardiac dyssynchrony in patients with dilated cardiomyopathy (DCM). " 12/01/2002 - "This study was performed to evaluate whether thallium-201 myocardial scintigraphy (Tl-201) and iodine-123-metaiodobenzylguanidine (MIBG) myocardial scintigraphy could predict the usefulness of beta-blocker therapy in patients with dilated cardiomyopathy (DCM). "
10.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 03/01/2010 - "Pediatric studies demonstrate safety and efficacy for use of angiotensin-converting enzyme inhibition and beta-blockers in dilated cardiomyopathy. " 09/01/2010 - "The aim of this study was to determine the association of angiotensin-converting enzyme I/D polymorphism with the risk of dilated cardiomyopathy in a Tunisian population. " 09/01/2010 - "DD genotype and D allele of angiotensin-converting enzyme I/D gene polymorphism are associated with increased risk of dilated cardiomyopathy in a Tunisian population but do not influence the cardiac phenotype severity." 02/01/2008 - "Association between angiotensin converting enzyme (ACE) gene I/D polymorphism frequency and plasma ACE concentration in patients with idiopathic dilated cardiomyopathy." 01/01/2003 - "Thus, beta-blocker should be added to patients with dilated cardiomyopathy treated with an angiotensin-converting enzyme inhibitor."

Therapies and Procedures

1.	Heart Transplantation (Grafting, Heart) 02/01/1996 - "These results indicate that structural microangiopathy and minimal vascular resistance in skin are improved slowly and gradually within the first year after orthotopic cardiac transplantation in patients with idiopathic dilated cardiomyopathy, however, the remodeling of histopathology is not accompanied by complete normalization." 03/01/1994 - "A minority of patients with dilated cardiomyopathy and symptoms for < or = 6 months will have marked improvement in left ventricular function, after which prognosis is excellent despite previous referral for heart transplantation. " 04/01/2003 - "Advances in medical therapy for dilated cardiomyopathy and cardiac transplantation have significantly improved the quality of life and survival for patients." 02/01/1998 - "The utility of immunosuppressive therapy remains ambiguous; however, other advances in medical therapy for dilated cardiomyopathy and cardiac transplantation have significantly improved quality of life and survival for patients. " 02/01/2015 - "Left ventriculoplasty (LVP) and mitral valve plasty (MVP) are sometimes effective for patients with idiopathic dilated cardiomyopathy (DCM) who are not eligible for heart transplantation. "
2.	Cardiac Resynchronization Therapy 01/01/2000 - "More recently, biventricular pacing has been proposed for the treatment of dilated cardiomyopathy and a French study showed a long-term improvement in NYHA stage and effort capacity. " 12/20/2005 - "Diastolic asynchrony is more frequent than systolic asynchrony in dilated cardiomyopathy and is less improved by cardiac resynchronization therapy." 11/02/2000 - "Biventricular pacing has evolved as a new treatment option for patients with dilated cardiomyopathy and conduction disturbances. " 08/01/2012 - "[Dilated cardiomyopathy with improved exercise tolerance after cardiac resynchronization therapy and mitral valve replacement with bileaflet preservation]." 01/01/2013 - "The aim of our study was to identify electrocardiographic predictors of response to cardiac resynchronization therapy (CRT) in patients with dilated cardiomyopathy (DCM). "
3.	Transplantation (Transplant Recipients) 01/01/2013 - "Dilated cardiomyopathy with depressed left ventricular ejection fraction markedly improved after transplantation, with normalization of the ejection fraction. " 04/25/2008 - "Clinical efficacy of skeletal myoblast (skMb) transplantation is controversial whether this treatment produces beneficial outcome in patients with dilated cardiomyopathy (DCM). " 09/01/2001 - "Although initial reports lacked significant information on the safety and efficacy of this procedure, overall clinical impression from the reports is that the operation may serve as a relatively inexpensive bridge to transplantation especially in the patients with idiopathic dilated cardiomyopathy. " 02/01/2015 - "Intracoronary transplantation of CD34(+) cells is associated with improved myocardial perfusion in patients with nonischemic dilated cardiomyopathy." 01/04/2013 - "CD34+ transplantation in dilated cardiomyopathy was associated with short-term improvement in left ventricular ejection fraction and exercise tolerance. "
4.	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 11/01/2013 - "To assess the incidence and prognostic significance of left ventricular (LV) function improvement in patients with non-ischaemic dilated cardiomyopathy (DCM) and prophylactic implantable cardioverter-defibrillator (ICD). " 05/01/2002 - "Evaluating predictors of appropriate implantable cardioverter-defibrillator (ICD) therapy in patients with idiopathic dilated cardiomyopathy (IDC) may be helpful in developing risk stratification strategies for these patients. " 04/01/2015 - "The main objectives of this study were to investigate the relationship between prolonged QRS interval and its prognosis in patients with dilated cardiomyopathy (DCM), and to determine the effects of cardiac pacing with an implantable cardioverter-defibrillator (ICD) on mortality in patients with a QRS width > 150 ms. We retrospectively queried the healthcare enterprise data warehouse and the patient medical records from January 2007 to December 2012 for 1453 cases of DCM at a university- affiliated hospital. " 06/01/2013 - "Sixty-nine patients with idiopathic dilated cardiomyopathy underwent implantable cardioverter-defibrillator (ICD) implantation: 41/44 in group I and 28/114 in group II. The major end points of the study were overall mortality and appropriate ICD activation. " 04/01/2010 - "The SCD-HeFT study demonstrated a benefit of primary prevention implantable cardioverter-defibrillator (ICD) implantation in patients with non-ischaemic dilated cardiomyopathy (NIDCM). "
5.	Drug Therapy (Chemotherapy) 01/01/2003 - "The study population consisted of 62 patients (85% men, 71 +/- 10 years old) with advanced dilated cardiomyopathy, in NYHA Class III or IV despite optimal drug therapy, and a QRS duration > 150 ms. Patients in sinus rhythm were implanted with a triple chamber pacemaker to maintain atrioventricular synchrony. " 03/01/2015 - "Resolution of dilated cardiomyopathy in an adolescent with change of a failing highly active antiretroviral drug therapy." 01/01/2015 - "Pharmacotherapy of dilated cardiomyopathy." 01/01/2012 - "A 29-year-old woman had undergone anthracycline-based chemotherapy as a teenager in 1991 and 1992 and received a diagnosis of dilated cardiomyopathy 10 years later. " 02/01/2011 - "We have previously shown that a specific combination of drug therapy and left ventricular assist device unloading results in significant myocardial recovery, sufficient to allow pump removal, in two thirds of patients with dilated cardiomyopathy receiving a Heartmate I pulsatile device. "