Alcoholic Cardiomyopathy

Disease of CARDIAC MUSCLE resulting from chronic excessive alcohol consumption. Myocardial damage can be caused by: (1) a toxic effect of alcohol; (2) malnutrition in alcoholics such as THIAMINE DEFICIENCY; or (3) toxic effect of additives in alcoholic beverages such as COBALT. This disease is usually manifested by DYSPNEA and palpitations with CARDIOMEGALY and congestive heart failure (HEART FAILURE).

Also Known As:

Networked: 125 relevant articles (2 outcomes, 13 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Sudden Death
2.	Myocarditis (Carditis)
3.	Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
4.	Poisoning
5.	Cardiac Sudden Death (Sudden Cardiac Arrest)

Experts

1.	Jing, Ling: 11 articles (01/2015 - 07/2008)
2.	Ren, Jun: 11 articles (01/2013 - 03/2003)
3.	Zhou, Li-jun: 8 articles (01/2012 - 07/2008)
4.	Li, Wei-min: 7 articles (01/2012 - 07/2008)
5.	Fernández-Solà, Joaquim: 6 articles (12/2013 - 01/2002)
6.	Sang, Ying: 5 articles (01/2012 - 01/2011)
7.	Song, Jian: 5 articles (01/2011 - 07/2008)
8.	Li, Shuang: 4 articles (01/2012 - 09/2008)
9.	Yuan, Lin: 4 articles (01/2012 - 01/2011)
10.	Sacanella, Emilio: 4 articles (09/2011 - 02/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Alcoholic Cardiomyopathy:

1.	Ethanol (Ethyl Alcohol)IBA 02/05/2002 - "In patients with alcoholic cardiomyopathy, both abstinence and controlled drinking of up to 60 g of ethanol per day (four standard drinks) were comparably effective in promoting improvement in cardiac function." 12/01/1998 - "Prospective observational study with 20 patients with alcoholic cardiomyopathy (ACM), 9 (45%) in functional class (FC) II and 11 (55%) in FC III, 16 (80%) men, mostly black (55%), from 35 to 56 (x = 45) years old, heavy alcohol users (> 80 g ethanol for 51 to 112 (x = 88) months. " 03/01/2003 - "Acute ethanol exposure depresses ventricular contractility and contributes to alcoholic cardiomyopathy in both men and women chronically consuming ethanol. " 11/01/2000 - "Long-standing ethanol consumption acts as a chronic cardiac stress and often leads to alcoholic cardiomyopathy. " 08/01/1996 - "Changes in cardiac signal transduction systems in chronic ethanol treatment preceding the development of alcoholic cardiomyopathy."
2.	PractololIBA 05/01/1984 - "This paper reports a case of severe low output cardiac failure due to congestive (alcoholic) cardiomyopathy which was unresponsive to dopamine infusion, but which improved rapidly on intravenous practolol therapy. "
3.	Dopamine (Intropin)FDA LinkGeneric 05/01/1984 - "This paper reports a case of severe low output cardiac failure due to congestive (alcoholic) cardiomyopathy which was unresponsive to dopamine infusion, but which improved rapidly on intravenous practolol therapy. "
4.	2- amino- 3- cyano- 6- methyl- 5- (4- pyridyl)pyridineIBA 03/01/2015 - "The results of immunohistochemical studies of the sinoatrial node---???---(SAN) and the working myocardium in the patients presenting with alcoholic cardiomyopathy (ACMP) are presented. " 11/01/2004 - "Significance, of the weight and dimensions of heart as well as of fat dystrophy of cardiomyocytes and of the related detection methods is demonstrated for the diagnosis of alcoholic cardiomyopathy (ACMP). " 08/01/1989 - "The model experiment with rats was undertaken to assess a reversibility of alcoholic cardiomyopathy (ACMP). " 01/01/1981 - "A composite morpho-histo-biochemical and ultrastructural investigation of the myocardium of 50 subjects dying suddenly in the presence of alcoholic cardiomyopathy (ACMP) was carried out. " 09/01/2015 - "Immunohistochemical (IHC) methods and polymerase chain reaction (PCR) were employed to study the cases of death from alcoholic cardiomyopathy (ACMP) among the patients presenting with interstitial myocarditis who did not have this condition in their medical histories. "
5.	AcetaldehydeIBA 01/01/2008 - "Recent studies indicate that low concentrations of acetaldehyde may function as the primary factor in alcoholic cardiomyopathy by disrupting Ca(2+) handling or disturbing cardiac excitation-contraction coupling. " 04/14/2009 - "These data strongly support the notion that acetaldehyde may be an essential contributor to the chronic development of alcoholic cardiomyopathy." 01/01/2007 - "These data revealed that enhanced acetaldehyde production may be detrimental whereas facilitated acetaldehyde breakdown may be beneficial to alcoholic cardiomyopathy, indicating a possible therapeutic target against acetaldehyde in alcoholic tissue damage." 01/01/2007 - "Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models." 02/01/2006 - "Our data are consistent with the notion of acetaldehyde as a contributor to alcoholic cardiomyopathy and implicate the therapeutic potential of ALDH2 enzyme in alcoholic complications."
6.	EnzymesIBA 01/01/1987 - "[Role of peroxisomal enzymes and lipid peroxidation in the pathogenesis of alcoholic cardiomyopathy]." 01/01/1986 - "Study of the activity of some myocardial enzymes in sudden death cases with alcoholic cardiomyopathy (ACMP) was made by quantitative histochemical methods. " 01/01/1988 - "1. In order to test the hypothesis that the alcoholic cardiomyopathy under partial catalase inhibition is associated with the activation of lipid peroxidation in cardiomyocytes (Panchenko et al., Experientia 43, 580-581, 1987), the effects of ethanol and catalase inhibitor 3-amino-1,2,4-triazole (aminotriazole) on rat heart and liver content of reduced glutathione and on the activity of enzymes related to peroxide metabolism: catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase and glucose-6-phosphate dehydrogenase were investigated. "
7.	Cytochrome P-450 CYP2E1 (CYP2E1)IBA 01/01/2012 - "The aim of this study was to investigate the relationship between CYP2E1 activity and markers of oxidative stress and cardiac cell apoptosis during the development of alcoholic cardiomyopathy (ACM). " 01/01/2012 - "Chronic alcohol intake-induced oxidative stress and apoptosis: role of CYP2E1 and calpain-1 in alcoholic cardiomyopathy." 01/01/2013 - "Taken together, these findings suggest that ethanol metabolism through CYP2E1 may contribute to the pathogenesis of alcoholic cardiomyopathy including myocardial contractile dysfunction, oxidative stress and apoptosis, possibly through activation of JNK and ASK-1 signaling."
8.	Adrenergic Receptors (Adrenergic Receptor)IBA 07/01/2010 - "Recent studies link altered cardiac beta-adrenergic receptor (AR) signaling to the pathology of alcoholic cardiomyopathy (ACM). "
9.	OxygenasesIBA 07/01/1999 - "Biochemical studies of monoamine oxygenases (MAO) were studied in albino rats and in subjects dead from ethanol poisoning, alcoholic cardiomyopathy, and coronary heart disease. "
10.	MyoglobinIBA 01/01/1985 - "Immunomorphological and biochemical study of the myoglobin in the myocardium of 118 males at the age of from 30 to 55 years who died suddenly from coronary insufficiency, chronic pulmonary-cardiac insufficiency and from alcoholic cardiomyopathy in Magadan and Moscow is described. " 01/01/1985 - "Almost two-fold decrease of the myoglobin concentration in the left ventricle without its visible hypertrophy was observed in alcoholic cardiomyopathy, this may serve as a complementary test in the diagnosis of this disease."

Therapies and Procedures

1.	Heart Transplantation (Grafting, Heart) 01/01/1998 - "[Alcoholic cardiomyopathy and heart transplantation]." 01/01/2002 - "Forty three patients including 18 with dilated cardiomyopathy (DCM), 14 with ischemic heart disease (IHD), 3 with myocarditides, 1 with alcoholic cardiomyopathy and 7 after cardiac transplantation. "
2.	Transplantation (Transplant Recipients) 02/01/1996 - "The unfavorable early outcome of patients receiving hearts from alcoholic donors suggests the presence of a subclinical alcoholic cardiomyopathy before transplantation and poor tolerance of rejection episodes after transplantation. " 11/01/2006 - "Before transplantation, 45.0%, 17.5%, 17.5% and 7.5% of patients were classified as IDC, CHD, alcoholic cardiomyopathy and hypertrophic cardiomyopathy. "
3.	Bed Rest (Bedrest) 11/01/1977 - "Over an 18-month period, 26 patients with alcoholic cardiomyopathy were followed in a modified bedrest program in the patients' homes. " 05/01/1971 - "Alcoholic cardiomyopathy managed with prolonged bed rest."
4.	Catheters 01/01/1994 - "We report the case of a 29-year-old man with decompensated alcoholic cardiomyopathy who developed a Staphylococcal pulmonic valve infective endocarditis during hemodynamic monitoring, as a consequence of catheter-related bacteremia. "
5.	Transplants (Transplant) 11/01/2006 - "Post-transplant CHD diagnosis was also established in 4 patients with a pre-transplant diagnosis of IDC, in 4 patients with presumptive alcoholic cardiomyopathy, in 1 patient with hypertensive cardiomyopathy and in 1 patient with a pre-transplant diagnosis of aortic valve disease. "