Cardiolipins (Cardiolipin)

Acidic phospholipids composed of two molecules of phosphatidic acid covalently linked to a molecule of glycerol. They occur primarily in mitochondrial inner membranes and in bacterial plasma membranes. They are the main antigenic components of the Wassermann-type antigen that is used in nontreponemal SYPHILIS SERODIAGNOSIS.

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Networked: 1178 relevant articles (16 outcomes, 87 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kagan, Valerian E: 10 articles (09/2015 - 09/2005)
2.	Schlame, Michael: 10 articles (04/2012 - 04/2002)
3.	Hatch, Grant M: 9 articles (11/2015 - 05/2002)
4.	Tyurina, Yulia Y: 9 articles (09/2015 - 09/2005)
5.	Shoenfeld, Y: 9 articles (04/2007 - 05/2000)
6.	Han, Xianlin: 8 articles (11/2015 - 12/2005)
7.	Tyurin, Vladimir A: 8 articles (09/2015 - 09/2005)
8.	Sparagna, Genevieve C: 8 articles (09/2014 - 06/2005)
9.	Greenberg, Miriam L: 8 articles (04/2014 - 01/2004)
10.	Wanders, Ronald J A: 8 articles (09/2013 - 09/2002)

Related Diseases

1.	Syphilis 04/01/1979 - "Associated with the cardiolipin test it may be preferably used for the detection of syphilis, and moreover, passive haemagglutination may confirm the diagnosis in case of weak positive results with the FTA--ABS test. " 04/01/1978 - "Studies were carried out on the comparative value of passive haemaglutination, cardiolipin and treponema tests in a total number of 4327 sera syphilitic patients in various stages of the disease and apparently normal subjects or free of syphilis. " 01/01/1953 - "[On the use of serological micromethods in the study of syphilis; the cardiolipin microtest and a modified Meinicke micromethod]." 11/01/1992 - "Enhancement of cardiolipin binding activity by beta 2GP1 was observed for APS, but not for syphilis. " 09/01/1992 - "Cardiolipin antibody (VDRL) was positive but specific tests for syphilis were negative. "
2.	Thrombosis (Thrombus) 07/01/2005 - "Although the presence of left atrial thrombus was much more frequent in cardiolipin positive patients (13% versus 4%, respectively), the difference was not statistically significant (P = 0.19). " 12/01/2004 - "The use of an LAC assay with cardiolipin as confirming agent strongly improves the detection of patients at risk of thrombosis. " 01/01/1994 - "Sneddon's syndrome, anti-cardiolipin antibody and glomerular thrombosis." 07/01/1989 - "The cardiolipin-positive group had significantly lower platelet counts, but no increased history of thrombosis was observed. " 06/01/2015 - "Moreover, 11 studies (257 cases, 1079 controls) showed a higher prevalence of venous and/or arterial thrombosis in patients with hepatitis and anti-cardiolipin antibody positivity compared hepatitis alone (OR 3.29, 95% CI: 1.79-6.07). "
3.	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome) 11/01/2012 - "The aim of this study was to evaluate the expression of T-helper cell subtypes Th1, Th2, Th17 and Treg in antiphospholipid syndrome (APS), and whether they are related to anti-cardiolipin antibody (aPL) titers. " 07/01/2013 - "Adult female mice were immunized with cardiolipin and beta-2-glycoprotein-1 to induce experimental anti-phospholipid syndrome. " 04/01/2007 - "To determine the autoantibody nature of these Abs, we have compared their reactivities with human anti-cardiolipin mAbs derived from a primary antiphospholipid syndrome patient. " 08/01/2005 - "It seems that determination of aPLs only against cardiolipin in reproductive failure is not sufficient for obstetric-gynecology diagnosis as the primary anti-phospholipid syndrome. " 01/01/2003 - "Anti-cardiolipin and anti-beta2-glycoprotein I (beta2GP-I) antibody assays as screening for anti-phospholipid syndrome."
4.	Barth Syndrome 01/17/2014 - "Importantly, preventing cardiolipin remodeling initiation in yeast lacking TAZ1, an ortholog of the causative gene in Barth syndrome, ameliorates mitochondrial dysfunction. " 09/01/2002 - "Quantitative and compositional study of cardiolipin in platelets by electrospray ionization mass spectrometry: application for the identification of Barth syndrome patients." 09/01/2015 - "Cardiolipin fingerprinting of leukocytes by MALDI-TOF/MS as a screening tool for Barth syndrome." 03/01/2015 - "Barth syndrome without tetralinoleoyl cardiolipin deficiency: a possible ameliorated phenotype." 04/01/2014 - "The functions of cardiolipin in cellular metabolism-potential modifiers of the Barth syndrome phenotype."
5.	Infection 03/01/2007 - "To elucidate the roles of VP1u in B19 infection and aPL production, the major reactivity of anti-B19-VP1u, anti-cardiolipin antibody (aCL), and anti-beta2-glycoprotein I (beta2GPI) antibody was evaluated. " 06/01/2003 - "The occurrence of Bacteroides species infection with transient anti-cardiolipin antibody has not been previously reported." 02/13/1998 - "Cardiolipin remodeling in mammalian eukaryotic cells was examined subsequent to infection with Chlamydia trachomatis, an intracellular parasite of eukaryotic cells. " 11/01/1995 - "Human immunodeficiency virus rather than hepatitis C virus infection is relevant to the development of an anti-cardiolipin antibody." 11/11/1982 - "The quantitative Cardiolipin Microflocculation test (CMT) decides on the activity of the lues infection and can be used to follow up the effectiveness of treatment. "

Related Drugs and Biologics

1.	Antibodies
2.	Antigens
3.	Phospholipids
4.	beta 2-Glycoprotein I (Apolipoprotein H)
5.	Liposomes (Liposome)
6.	Antiphospholipid Antibodies
7.	Glycoproteins (Glycoprotein)
8.	Doxorubicin (Adriamycin)
9.	2-naphthylaminomethyl-gamma-aminobutyric acid (A 144)
10.	Complement System Proteins (Complement)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Bariatric Surgery
3.	Heterologous Transplantation (Xenotransplantation)
4.	Resuscitation
5.	Lasers (Laser)