Low Cardiac Output

A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.
Also Known As:
Cardiac Output, Low; Output, Low Cardiac; Low Cardiac Output Syndrome
Networked: 979 relevant articles (56 outcomes, 56 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Heart Failure
2. Myocardial Ischemia (Ischemic Heart Diseases)
3. Aortic Valve Stenosis (Aortic Stenosis)
4. Coronary Artery Disease (Coronary Atherosclerosis)
5. Hypotension (Low Blood Pressure)


1. Chang, Anthony C: 7 articles (09/2010 - 01/2002)
2. Mohr, Friedrich W: 6 articles (05/2015 - 11/2003)
3. Walther, Thomas: 5 articles (05/2015 - 11/2003)
4. Ranucci, Marco: 5 articles (08/2013 - 02/2005)
5. Atz, Andrew M: 5 articles (04/2012 - 01/2002)
6. Wernovsky, Gil: 5 articles (03/2007 - 01/2002)
7. Pagano, Domenico: 4 articles (03/2015 - 06/2005)
8. Sabzi, Feridoun: 4 articles (01/2015 - 04/2013)
9. Frigiola, Alessandro: 4 articles (08/2013 - 02/2005)
10. Falk, Volkmar: 4 articles (06/2005 - 11/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Low Cardiac Output:
1. DobutamineFDA LinkGeneric
2. simendan (Levosimendan)IBA
3. Amrinone (Amrinon)FDA Link
4. Milrinone (Primacor)FDA LinkGeneric
5. dopexamineIBA
6. EnoximoneIBA
7. Epinephrine (Adrenaline)FDA LinkGeneric
8. Carbon MonoxideIBA
9. glucuronyl glucosamine glycan sulfate (Vessel)IBA
04/01/1996 - "Although the Q-wave MI rate, the peak CPK level and the reperfusion rate were no different, the low cardiac output condition, multi vessel disease and short-term mortality were significantly greater in the older group. "
12/01/2007 - "In the right ventricular outlet reconstruction patients, the McGoon index for patients with low cardiac output syndrome (LCOS) was 1.36 +/- 0.51, and 1.97 +/- 0.58 for patients without LCOS (t = 2.347, P < 0.05), the Nakata index for patients with LCOS was 164 +/- 106 mm(2)/m(2) and 269 +/- 124 mm(2)/m(2) for patients without LCOS (t = 2.218, P < 0.05), the PVI for patients with LCOS was 152 +/- 77 mm(2)/m(2) and 273 +/- 125 mm(2)/m(2) for patients without LCOS (t = 2.936, P < 0.01), pulmonary vessel index of patients with LCOS was less than that of those without LCOS. "
01/01/2003 - "CHF is associated with abnormalities of flow (low cardiac output, dilated cardiac chambers), vessel wall (endothelial dysfunction), and abnormalities of blood constituents (abnormalities of platelets and haemorrheology). "
04/01/1999 - "In addition to "abnormal flow" through low cardiac output, dilated cardiac chambers and poor contractility, patients with heart failure also demonstrate abnormalities of hemostasis and platelets (that is "abnormal blood constituents") and endothelial dysfunction ("vessel wall abnormalities"). "
05/01/1977 - "The published reports of this type of gangrene indicate that it may result from (1) va sospastic conditions, (2) small vessel obstruction, or (3) conditions producing a very low cardiac output. "
10. Atrial Natriuretic Factor (ANF)IBA
11/01/2011 - "Determination of the plasma ANP and hs-CRP level may be helpful for decisions related to early diagnosis of patient with low cardiac output."
09/01/1992 - "In addition, we sought to determine whether this model of low cardiac output would show a full vasoconstrictive response to exogenous ET infusion and whether atrial natriuretic factor (ANF) infused acutely to achieve pathophysiological concentrations would modulate the systemic and renal hemodynamic responses to exogenous ET. "
05/01/1994 - "A patient with acute right ventricular infarction who showed hyposecretion of atrial natriuretic peptide (ANP) in spite of abnormally high right atrial pressure and who died of a severe low cardiac output syndrome is reported. "
10/01/1992 - "1) The inhibition of ANF degradation causes sustained drop in left and right atrial pressures that appears to be mediated by an inhibition of neurohumoral activity; 2) concomitant inhibition of bradykinin breakdown (which in turn stimulates renal prostacyclin synthesis) contributes to natriuresis; 3) the close correlation between renal response and baseline cardiac index indicates that an inadequate renal perfusion secondary to low cardiac output diminishes the efficacy of this treatment modality. "
10/01/1994 - "Most clinical symptoms of congestive heart failure (CHF) were apparent after the 14 days, characterized by low cardiac output, high venous pressure, increased total peripheral resistance, increased plasma levels of ANF, noradrenaline, arginine vasopressin and renin, and marked fluid retention. "

Therapies and Procedures

1. Cardiopulmonary Bypass (Heart-Lung Bypass)
2. Coronary Artery Bypass (Coronary Artery Bypass Surgery)
3. Counterpulsation (External Counterpulsation)
4. Right Heart Bypass (Cavopulmonary Anastomosis)
5. Resuscitation