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Cardiac Glycosides

Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.
Also Known As:
Glycoside, Cardiac; Glycosides, Cardiac; Steroid, Cardiotonic; Steroids, Cardiotonic; Cardiac Glycoside; Cardiotonic Steroid; Cardiotonic Steroids
Networked: 1001 relevant articles (44 outcomes, 98 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Bagrov, Alexei Y: 25 articles (04/2022 - 03/2006)
2. Fedorova, Olga V: 21 articles (04/2022 - 03/2006)
3. Shapiro, Joseph I: 18 articles (01/2019 - 03/2006)
4. Malhotra, Deepak: 14 articles (01/2020 - 03/2006)
5. Newman, Robert A: 13 articles (01/2022 - 01/2006)
6. Xie, Zijian: 12 articles (03/2021 - 03/2006)
7. Yang, Peiying: 11 articles (01/2022 - 01/2006)
8. Kennedy, David J: 11 articles (01/2020 - 03/2006)
9. Lingrel, Jerry B: 9 articles (03/2021 - 02/2005)
10. Tang, Jin-Shan: 9 articles (09/2020 - 09/2013)

Related Diseases

1. Heart Failure
2. Neoplasms (Cancer)
3. Lung Neoplasms (Lung Cancer)
4. Hypertension (High Blood Pressure)
5. Cardiac Arrhythmias (Arrythmia)

Related Drugs and Biologics

1. Digoxin (Digitek)
2. Ouabain (G Strophanthin)
3. Digitoxin
4. Diuretics
5. oleandrin
6. Calcium
7. Vasodilator Agents (Vasodilators)
8. Oxygen (Dioxygen)
9. Cardiotonic Agents (Cardiac Stimulants)
10. Antihypertensive Agents (Antihypertensives)

Related Therapies and Procedures

1. Therapeutics
2. Microspheres (Microsphere)
3. Premedication
4. Renal Dialysis (Hemodialysis)
5. Drug Therapy (Chemotherapy)