Cardenolides

C(23)-steroids with methyl groups at C-10 and C-13 and a five-membered lactone at C-17. They are aglycone constituents of CARDIAC GLYCOSIDES and must have at least one double bond in the molecule. The class includes cardadienolides and cardatrienolides. Members include DIGITOXIN and DIGOXIN and their derivatives and the STROPHANTHINS.

Also Known As:

Networked: 137 relevant articles (7 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kiss, Robert: 10 articles (06/2013 - 02/2006)
2.	Kreis, Wolfgang: 8 articles (04/2021 - 10/2015)
3.	Mijatovic, Tatjana: 8 articles (06/2011 - 02/2006)
4.	Munkert, Jennifer: 7 articles (04/2021 - 02/2017)
5.	Braga, Fernão C: 6 articles (01/2021 - 06/2016)
6.	Pádua, Rodrigo M: 6 articles (01/2021 - 06/2016)
7.	Lee, Shiow-Ju: 5 articles (10/2020 - 10/2017)
8.	Yang, Cheng-Wei: 5 articles (10/2020 - 10/2017)
9.	Barbosa, Leandro A: 4 articles (04/2021 - 01/2014)
10.	Persich, Lara: 4 articles (04/2021 - 06/2016)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "Background: Several studies have shown that active compounds of Asclepias subulata (cardenolides) have antiproliferative effect on human cancer cells. " 01/01/2022 - "Background: Several studies have shown that active compounds of Asclepias subulata (cardenolides) have antiproliferative effect on human cancer cells. " 04/01/2019 - "To date, cardenolides have received considerable attention in pharmacology studies due to their direct effects of apoptosis-induction or growth-inhibitory against tumor in vitro and in vivo. " 03/31/2015 - "Cardenolides with special chemical structures have been considered as effective anti-cancer drugs in clinic trials. " 01/01/2012 - "Moreover, pharmacological data from in vitro and in vivo experiments, as well as pre-clinical and clinical trials regarding cardenolides to combat cancers associated with dismal prognoses are presented."
2.	Hypertension (High Blood Pressure) 01/01/2017 - "containing species, commonly known as the "foxglove", is the main source of cardenolides, which have various pharmacological properties effective against certain pathological conditions including myocardial infarction, arterial hypertension, cardiac dysfunction, angina, and hypertrophy. " 06/01/2012 - "Furthermore, these minerals, alkaloids and cardenolides could be helpful in ameliorating complications of diabetes like hypertension and cardiovascular disease." 09/01/2005 - "Long-term treatment of rats with ouabain results in arterial hypertension, and 50% of Caucasians with low-renin hypertension have increased plasma concentrations of this cardenolide. " 04/20/2014 - "Using immunoassays, clinical studies found the cardenolide ouabain to be secreted endogenously in response to exercise and untreated hypertension and to be correlated with severity of clinical conditions such as kidney failure and dilated cardiomyopathy. " 07/01/2016 - "Endogenous cardenolides are digoxin-like substances and ouabain-like substances that have been implicated in the pathogenesis of hypertension and mood disorders in clinical and pre-clinical studies. "
3.	Leukemia 12/01/2023 - "To the best of our knowledge, this is the first time to describe a cardenolide that induces parthanatos in leukemia cells, which may help to improve efforts to overcome drug resistance in cancer. " 10/01/2015 - "The new cardenolide analog AMANTADIG appears effective in cell growth inhibition of leukemia and urological tumor cell lines." 10/01/2015 - "The prostate cancer and renal cell carcinoma cell lines were equally sensitive to AMANTADIG and digitoxin, however, the leukemia cell lines were more sensitive to both cardenolides. " 10/01/2015 - "The New Semisynthetic Cardenolide Analog 3β-[2-(1-Amantadine)-1-on-ethylamine]-digitoxigenin (AMANTADIG) Efficiently Suppresses Cell Growth in Human Leukemia and Urological Tumor Cell Lines." 10/01/2015 - "The aim of the present study was to characterize the cytotoxic effects of the new semisynthetic cardenolide analog AMANTADIG (3β-[2-(1-amantadine)-1-on-ethylamine]-digitoxigenin), and the cardenolide digitoxin on leukemia and urological tumor cell lines. "
4.	Poisoning 10/18/2006 - "Randomised controlled trials where antidotes were administered to patients with acute symptomatic cardenolide poisoning were identified. " 01/01/2021 - "The Nerium oleander plant contains cardenolides that may cause human poisoning when ingested. " 01/01/2018 - "Novel methods of self-poisoning: repeated cardenolide poisoning after accessing Cerbera odollam seeds via the internet." 12/01/2017 - "However, poisoning of the larvae by low levels of cardenolides is assumed to be prevented by non-resorption and excretion of the polar cardenolides, which cannot passively permeate the midgut membrane. " 01/01/2010 - "Elsewhere previous descriptions of human poisoning with the kernel of fruits of trees belonging to the genus Cerbera, known to contain cardiotoxic cardenolides, appear to be very similar to our cases. "
5.	Hypertrophy 01/01/2017 - "containing species, commonly known as the "foxglove", is the main source of cardenolides, which have various pharmacological properties effective against certain pathological conditions including myocardial infarction, arterial hypertension, cardiac dysfunction, angina, and hypertrophy. " 01/01/2001 - "Understanding the mechanisms for the release of mammalian cardenolides in plasma, the alterations in sodium pump isoforms and function, and the modulation of pathways involving calcium in hypertrophy and CHF may assist in the development of new biological markers capable of predicting the disease before significant progression and irreversible heart failure."

Related Drugs and Biologics

1.	Glycosides
2.	3- (2- (1- amantadine)- 1- one- ethylamine)digitoxigenin
3.	Digoxin (Digitek)
4.	UNBS 1450
5.	Steroids
6.	Charcoal (Charbon)
7.	Antitoxins
8.	Anthraquinones
9.	Sodium Bicarbonate (Baking Soda)
10.	Vitamins

Related Therapies and Procedures

1.	Castration
2.	Therapeutics
3.	Traditional Medicine (Folk Remedies)
4.	Transcutaneous Electric Nerve Stimulation (TENS)
5.	Denervation