Papillary Carcinoma

A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)

Also Known As:

Networked: 1601 relevant articles (20 outcomes, 140 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Carcinoma (Carcinomatosis)
2.	Adenoma (Adenomas)
3.	Neoplasms (Cancer)
4.	Neoplasm Metastasis (Metastasis)
5.	Thyroid Neoplasms (Thyroid Cancer)

Experts

1.	Miyauchi, Akira: 19 articles (01/2015 - 08/2002)
2.	Ito, Yasuhiro: 18 articles (01/2015 - 05/2003)
3.	Santin, Alessandro D: 13 articles (07/2013 - 10/2004)
4.	Kobayashi, Kaoru: 12 articles (01/2015 - 05/2003)
5.	Santoro, Massimo: 12 articles (03/2010 - 01/2002)
6.	Takamura, Yuuki: 12 articles (10/2009 - 05/2003)
7.	Bellone, Stefania: 11 articles (07/2013 - 10/2004)
8.	Pecorelli, Sergio: 11 articles (07/2013 - 10/2004)
9.	Fusco, Alfredo: 11 articles (04/2011 - 01/2002)
10.	Miya, Akihiro: 11 articles (10/2009 - 05/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Papillary Carcinoma:

1.	ParaffinIBA 02/01/2002 - "Histological examination of the operative specimen after total blocking in paraffin helped discover microscopic foci of papillary carcinoma in the thyroid gland. " 11/01/2015 - "In the first one a classical Sistrunk operation was performed removing a 3 cm asymptomatic mass, a milimetric papillary carcinoma being incidentally discovered at paraffin section pathology. " 10/25/2006 - "Immunohistochemical staining for CD57 and GLUT-1 was performed on paraffin-embedded cell blocks of 50 thyroid FNA cases with the following cytologic diagnoses: 1) papillary carcinoma (15 cases); 2) atypical cytology, cannot exclude papillary carcinoma (14 cases); and 3) benign thyroid (21 cases). " 12/01/2005 - "Of 10 serous papillary carcinomas, 8 (80%) for which paraffin blocks were available overexpressed the p53 protein. " 10/31/2004 - "Seventy paraffin-embedded conventional papillary carcinomas in the thyroid gland were evaluated. "
2.	IodineIBA 04/01/2009 - "Most studies attribute this rise entirely to the increase in papillary carcinoma, the most common thyroid malignancy in iodine-sufficient areas. " 11/01/2011 - "The data might suggest that immigrant populations in Sweden from areas of low or high-iodine intake are at risk of papillary carcinoma, implicating iodine imbalance as a contributing factor to our findings. " 07/01/2007 - "Papillary carcinoma is the most prevalent histological type, irrespective of gender and conditions like iodine level. " 07/01/2007 - "This may be related to increasing dietary iodine intake and may be significant as papillary carcinoma is associated with a more favourable prognosis." 07/01/2002 - "Patients who were born in iodine-sufficient areas (n=162/193, 84%; X(2)=5.09, P=0.02) had papillary carcinoma more frequently compared to patients who were born in previously iodine-deficient areas (n=159/214, 74%). "
3.	Galectin 3 (LGALS3)IBA 12/01/2014 - "The aim of this study was to investigate the ability of two immunohistochemical (IHC) markers; galectin-3 and Hector Battifora mesothelial-1 (HBME-1) individually or in combination, to distinguish between benign (non-neoplastic and neoplastic) and malignant (follicular and papillary carcinomas) thyroid lesions removed by surgical resection. " 07/01/2006 - "Our study shows that galectin-3 is strongly expressed in smears of papillary carcinoma. " 03/01/2012 - "Especially, strong and diffuse expressions of CK19, HBME-1 and galectin-3 were observed in papillary carcinomas. " 01/01/2012 - "The combination of Galectin-3 and PTTG is complementary as a diagnostic biomarker for patients with papillary carcinoma." 10/01/2010 - "Almost all the 20 cases of thyroid papillary carcinoma were intensely stained for CK19, galectin-3 and HBME-1. "
4.	AntibodiesIBA 10/01/1985 - "SOM-positive cells were identified in six cases and a-hCG or 5-HT-positive cells respectively in three cases of group III. Twenty follicular and 20 papillary carcinomas also included in this study did not react with any of the above mentioned antibodies. " 09/01/2006 - "One hundred and one cases of papillary carcinomas were studied with immunohistochemistry for RET antibodies. " 11/01/1999 - "Four of the cases of papillary carcinoma were also stained with antibodies to CK19. " 01/01/1986 - "Phosphofructokinase from papillary carcinomas show a lesser degree of precipitation with anti-M antibodies. " 11/01/2003 - "Indirect immunofluorescence using anti-EBNA2, anti-latent membrane protein-1 (LMP1), and anti-BZLF1 antibodies also showed positive results with high frequency and with more prominent fluorescence in undifferentiated carcinomas than in papillary carcinomas. "
5.	DNA (Deoxyribonucleic Acid)IBA 02/01/2007 - "DNA ploidy studies were carried out on 28 low-grade and 21 high-grade papillary carcinomas. " 03/01/1982 - "Chromosome and DNA cytometric study of a papillary carcinoma of the bladder with a high stemline and numerous double minutes." 02/01/2012 - "DNA of sufficient quality was extracted from 49 microdissected papillary carcinomas and 49 microdissected grade- and ER-matched IDC-NSTs. " 02/01/2007 - "The present findings establish that the DNA content is statistically different between low-grade and high-grade papillary carcinomas and that deviation from the diploid number is markedly higher in the high-grade ones. " 05/01/2005 - "The results indicate that despite the similar average distance between the AT- and the GC-rich DNA segments in the papillary carcinomas and the benign cases, the former has more heterogeneous distribution of the AT- and the GC-rich DNA segments in nuclei compared to the benign groups. "
6.	Thyroxine (Levothyroxine)FDA LinkGeneric 12/01/1994 - "In papillary carcinoma thyroxine administration (P < 0.005) and surgery (P < 0.001) improved survival together with youth (P < 0.001) and being female (P < 0.05). " 12/01/2003 - "A woman, thyroidectomised because of a thyroid papillary carcinoma, interrupted temporarily her levothyroxine intake in order to be subjected to an extension study five weeks later. " 01/01/1983 - "Furthermore, in three cases of papillary carcinoma the concentration of free thyroxin was increased, although all the other laboratory tests indicated a euthyroid state. " 02/01/2014 - "Here,we report 3 cases of primary ectopic thyroid papillary carcinoma, all of which were removed by surgery, take thyroxin orally after surgery and have a great prognosis." 11/01/1993 - "We underline the case of a patient, treated by total thyroidectomy for papillary carcinoma, who presented, two months after starting L-thyroxine therapy, a recurrence of celiac disease, that had been silent after childhood. "
7.	LectinsIBA 08/01/1986 - "In papillary carcinomas, the cells lining the papillary structures reacted focally with some lectins that did not bind to normal thyroid cells (S tuberosum and U europeaus in seven of seven cases; Helix pomatia, Helix aspersa, and soybean in four of seven cases; and peanut, Griffonia simplicifolia, D biflorus, and Vicia villosa in one of seven cases). " 12/01/1988 - "The results showed that (1) in normal thyroid glands, the lectin, UEA-I, is able to discriminate between follicular cells and C-cells; (2) pathologic follicular epithelium had an increased expression of UEA-I, SBA, and WGA receptors; (3) no lectin or group of lectins allow a distinction between follicular carcinoma and papillary carcinoma; (4) when benign and malignant tumors are compared for UEA-I affinity there is a significantly greater frequency of malignant tumour with UEA-I receptor; and (5) although all investigated lectins have shown receptors in endothelial cells at least in one case, the most constant findings have been obtained with UEA-I and WGA. " 12/01/1988 - "The authors carried out a histochemical study with lectins (Ulex europaeus agglutinin-I [UEA-I], Triticum vulgaris [WGA], Glycine max [SBA], Dolichos biflorus [DBA], and Arachis hypogaea [PNA]) in different thyroid gland conditions (17 benign nodular goiters, three diffuse hyperplasias, five Hashimoto's thyroiditis, 20 follicular adenomas, 14 well-differentiated papillary carcinomas, five well-differentiated follicular carcinomas, and 30 normal thyroids) in order to determine if specific lectin patterns are developed during neoplastic transformation. " 01/01/1996 - "Staining with lectins specific to poly-N-acetyllactosamine in combination with endo-beta-galactosidase digestion demonstrated that poly-N-acetyllactosaminyl structures ubiquitously and consistently produced in thyroid papillary carcinomas are highly heterogeneous in their chain length and branching status and quite different from those produced in other thyroid neoplasms. "
8.	Keratin-19 (Keratin 19)IBA 03/01/2008 - "Expression of cytokeratin 19 in the diagnosis of thyroid papillary carcinoma by quantitative polymerase chain reaction." 05/01/2003 - "Cytokeratin 19 immunostaining of cell block preparations of thyroid aspirates serves as a useful tool for the diagnosis of papillary carcinoma. " 11/01/1989 - "In papillary carcinoma, an identical homogeneous expression of keratin 19 was observed in both papillary and follicular structures, which suggests a common cellular origin. " 06/01/2010 - "It has concluded that cytokeratin-19 alone and its combinations with other markers were more sensitive in accurate diagnosis of papillary carcinoma than the other combinations; meanwhile, there were similar results for follicular carcinomas with HBME-1 alone and its combinations." 01/01/2005 - "The role of cytokeratin 19 in the differential diagnosis of true papillary carcinoma of thyroid and papillary carcinoma-like changes in Graves' disease."
9.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/01/1996 - "Tumor necrosis factor-alpha was demonstrated in thyroid follicular epithelial cells, most frequently in non-toxic multinodular goiters (six of seven patients) and less frequently in adenomas (three of nine patients), papillary carcinomas (two of five patients), follicular carcinomas (one of five patients), Hashimoto's disease (one of six patients) and Grave's disease (one of seven patients). " 04/01/1992 - "In a fifth neoplastic cell line (papillary carcinoma, NPA) that constitutively expressed surface DR, its expression was inhibited by both alpha-IFN and TNF-alpha and was not affected by EGF." 06/01/1995 - "Compared with follicular carcinomas, papillary carcinomas contained significantly higher numbers of DCs, interleukin (IL)-1 alpha- and tumor necrosis factor (TNF)-alpha-positive cells, and cells positive for two TNF-alpha receptors (p60 and p80). " 07/13/2000 - "The efficacy of TRAIL was also tested on other types of thyroid cancer cells like ARO, FRO (anaplastic carcinoma) and TPC-1 (papillary carcinoma) and compared to that triggered by other death inducing cytokines FasL and TNF-alpha. " 11/01/1996 - "Primary cultures of highly purified thyrocytes and thyroid-derived fibroblasts (n = 3) and three thyroid anaplastic and one largely papillary carcinoma cell lines were exposed to different potent GM-CSF stimulators, employing interleukin 1 alpha (Il-1 alpha) and tumour necrosis factor-alpha (TNF-alpha). "
10.	Chromosome 17 trisomyIBA 12/01/2005 - "However, the cases were atypical for type 1 papillary carcinoma (due to oncocytic cells and absence of trisomy 17) and for type 2 (due to a good outcome). " 01/01/2008 - "Isolated trisomy 17 is associated with focal papillary carcinoma changes in follicular-patterned thyroid nodules and may be a marker for this subset of thyroid lesions that are often difficult to classify." 01/01/2008 - "Trisomy 17 as a marker for a subset of noninvasive thyroid nodules with focal features of papillary carcinoma: cytogenetic and molecular analysis of 62 cases and correlation with histological findings." 03/01/1999 - "Of the papillary carcinomas, none had a 3p deletion, five had trisomies of both chromosomes 7 and 17, six had no changes in chromosomes 7 and 17, and three had either trisomy 7 or trisomy 17 but not both. " 01/01/2007 - "Fluorescence in situ hybridization analysis of nuclei isolated from paraffin-embedded tumor tissue detected monosomy 1, disomy 7, and monosomy 17, a common and characteristic finding in chromophobe carcinomas, in a majority of, but not all tumor cells, whereas a population characterized by disomy 1, trisomy 7, and trisomy 17, a frequent finding in papillary carcinoma, was not identifiable. "

Therapies and Procedures

1.	Thyroidectomy 05/01/2005 - "The preliminary results of this study showed that non endoscopic minimally invasive thyroidectomy could be proposed in patients with T1 papillary carcinoma. " 08/01/1995 - "The objective of the study was to assess surgical strategy of papillary carcinoma of the thyroid based on residual tumour findings after completion thyroidectomy. " 08/01/1993 - "Pathologic staging of papillary carcinoma of the thyroid with airway invasion based on the anatomic manner of extension to the trachea: a clinicopathologic study based on 22 patients who underwent thyroidectomy and airway resection." 04/01/1990 - "The results of this study suggest that the surgical approach in papillary carcinoma of the thyroid is total thyroidectomy because reoperation were performed in four patients." 10/01/2015 - "Our experience with MIVAT is represented by 2,413 cases between 1998 and 2014: in particular 821 patients were operated with a total thyroidectomy for a papillary carcinoma (34.0%). "
2.	Neck Dissection (Radical Neck Dissection) 06/01/2015 - "We present a patient who developed both conditions subsequent to excision of a papillary carcinoma with a neck dissection. " 01/01/2014 - "Lymph node ratio of the central compartment is a significant predictor for locoregional recurrence after prophylactic central neck dissection in patients with thyroid papillary carcinoma." 11/01/2012 - "Though its features are not significantly different from those of other papillary carcinomas, the optimal therapeutic approach continues to be an issue of controversy, most notably appropriate surgical approach and indications for neck dissection. " 09/01/2010 - "To investigate the effect of VI region neck dissection in thyroid papillary carcinoma surgery and to prompt the key matters in such surgery. " 04/01/2009 - "Prophylactic neck dissection for small papillary carcinoma remains controversial. "
3.	Lymph Node Excision (Lymph Node Dissection) 11/01/2011 - "Fifty-one consecutive patients with papillary carcinomas without clinical evidence of cervical lymph node involvement were included in the study between August 2007 and September 2010, in which 53 sides underwent neck lymph node dissection. " 11/02/2000 - "For N-staging selective lymphadenectomy was carried out at the beginning of the study, but elective lymphadenectomy was used since 1996 for papillary carcinoma. " 08/01/1986 - "[Study on extensive lymph node dissection: metastatic lymph nodes in papillary carcinoma of the thyroid]." 08/01/2015 - " are removed by endoscopic snare papillectomy whereas the therapy of choice for papillary carcinomas is pancreatic head resection with systematic lymphadenectomy. " 12/01/2013 - "[Clinical research strategy for cN0 thyroid papillary carcinoma central lymph node dissection]."
4.	Drug Therapy (Chemotherapy) 07/01/2009 - "scFv H6 may represent a novel antitumor agent against chemotherapy-resistant ovarian and serous papillary carcinomas and other human malignancies that overexpress CLDN3." 06/01/1979 - "The second case is a papillary carcinoma and associated microacinar type with the papillary component responding dramatically to chemotherapy. " 10/01/1966 - "Intracavitary chemotherapy of diffuse non-infiltrating papillary carcinoma of the bladder." 12/01/2013 - "To evaluate patterns of relapse in early stage uterine papillary carcinoma (UPSC) patients receiving adjuvant intravaginal radiotherapy (IVRT) with or without chemotherapy. " 11/01/2006 - "In addition, one case of thyroid papillary carcinoma located at neck-root and mediastinum remained alive for 40 months after operation combined with radiotherapy and chemotherapy. "
5.	Intravesical Administration 04/01/1993 - "A prospective European Organization for Research and Treatment of Cancer Genitourinary Group randomized trial comparing transurethral resection followed by a single intravesical instillation of epirubicin or water in single stage Ta, T1 papillary carcinoma of the bladder." 01/01/1993 - "We compared intravesical instillations with mitomycin-C (MMC), Bacillus Calmette-Guerin (BCG) Tice, and BCG-RIVM in patients with pTa-pT1 papillary carcinoma and primary carcinoma in situ (CIS) of the bladder. " 08/01/2001 - "Intravesical instillation of epirubicin, bacillus Calmette-Guerin and bacillus Calmette-Guerin plus isoniazid for intermediate and high risk Ta, T1 papillary carcinoma of the bladder: a European Organization for Research and Treatment of Cancer genito-urinary group randomized phase III trial."