Papillary Carcinoma

A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
Also Known As:
Carcinoma, Papillary; Carcinomas, Papillary; Papillary Carcinomas
Networked: 1601 relevant articles (20 outcomes, 140 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Carcinoma (Carcinomatosis)
2. Adenoma (Adenomas)
3. Neoplasms (Cancer)
4. Neoplasm Metastasis (Metastasis)
5. Thyroid Neoplasms (Thyroid Cancer)


1. Miyauchi, Akira: 19 articles (01/2015 - 08/2002)
2. Ito, Yasuhiro: 18 articles (01/2015 - 05/2003)
3. Santin, Alessandro D: 13 articles (07/2013 - 10/2004)
4. Kobayashi, Kaoru: 12 articles (01/2015 - 05/2003)
5. Santoro, Massimo: 12 articles (03/2010 - 01/2002)
6. Takamura, Yuuki: 12 articles (10/2009 - 05/2003)
7. Bellone, Stefania: 11 articles (07/2013 - 10/2004)
8. Pecorelli, Sergio: 11 articles (07/2013 - 10/2004)
9. Fusco, Alfredo: 11 articles (04/2011 - 01/2002)
10. Miya, Akihiro: 11 articles (10/2009 - 05/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Papillary Carcinoma:
1. ParaffinIBA
2. IodineIBA
3. Galectin 3 (LGALS3)IBA
4. AntibodiesIBA
5. DNA (Deoxyribonucleic Acid)IBA
6. Thyroxine (Levothyroxine)FDA LinkGeneric
7. LectinsIBA
08/01/1986 - "In papillary carcinomas, the cells lining the papillary structures reacted focally with some lectins that did not bind to normal thyroid cells (S tuberosum and U europeaus in seven of seven cases; Helix pomatia, Helix aspersa, and soybean in four of seven cases; and peanut, Griffonia simplicifolia, D biflorus, and Vicia villosa in one of seven cases). "
12/01/1988 - "The results showed that (1) in normal thyroid glands, the lectin, UEA-I, is able to discriminate between follicular cells and C-cells; (2) pathologic follicular epithelium had an increased expression of UEA-I, SBA, and WGA receptors; (3) no lectin or group of lectins allow a distinction between follicular carcinoma and papillary carcinoma; (4) when benign and malignant tumors are compared for UEA-I affinity there is a significantly greater frequency of malignant tumour with UEA-I receptor; and (5) although all investigated lectins have shown receptors in endothelial cells at least in one case, the most constant findings have been obtained with UEA-I and WGA. "
12/01/1988 - "The authors carried out a histochemical study with lectins (Ulex europaeus agglutinin-I [UEA-I], Triticum vulgaris [WGA], Glycine max [SBA], Dolichos biflorus [DBA], and Arachis hypogaea [PNA]) in different thyroid gland conditions (17 benign nodular goiters, three diffuse hyperplasias, five Hashimoto's thyroiditis, 20 follicular adenomas, 14 well-differentiated papillary carcinomas, five well-differentiated follicular carcinomas, and 30 normal thyroids) in order to determine if specific lectin patterns are developed during neoplastic transformation. "
01/01/1996 - "Staining with lectins specific to poly-N-acetyllactosamine in combination with endo-beta-galactosidase digestion demonstrated that poly-N-acetyllactosaminyl structures ubiquitously and consistently produced in thyroid papillary carcinomas are highly heterogeneous in their chain length and branching status and quite different from those produced in other thyroid neoplasms. "
8. Keratin-19 (Keratin 19)IBA
9. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
10. Chromosome 17 trisomyIBA

Therapies and Procedures

1. Thyroidectomy
2. Neck Dissection (Radical Neck Dissection)
3. Lymph Node Excision (Lymph Node Dissection)
4. Drug Therapy (Chemotherapy)
5. Intravesical Administration