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Mucinous Adenocarcinoma (Mucinous Carcinoma)

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An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)

Also Known As:

Mucinous Carcinoma; Adenocarcinoma, Mucinous; Adenocarcinomas, Mucinous; Carcinomas, Colloid; Carcinomas, Mucinous; Colloid Carcinoma; Colloid Carcinomas; Mucinous Adenocarcinomas; Mucinous Carcinomas; Carcinoma, Colloid; Carcinoma, Mucinous

Networked: 799 relevant articles (18 outcomes, 50 trials/studies)

Relationship Network

Disease Context: Research Results

Neoplasms: 649836
- Neoplasms by Histologic Type: 1
  - Glandular and Epithelial Neoplasms: 332
    - Carcinoma: 115405
      - Adenocarcinoma: 37102
        Mucinous Adenocarcinoma: 799
    - Neoplasms, Cystic, Mucinous, and Serous
      - Mucinous Adenocarcinoma: 799

Related Diseases

1.	Neoplasms (Cancer)
2.	Adenocarcinoma
3.	Carcinoma (Carcinomatosis)
4.	Residual Neoplasm
5.	Pancreatic Neoplasms (Pancreatic Cancer)

Experts

1.	Köbel, Martin: 5 articles (11/2015 - 01/2009)
2.	Gilks, C Blake: 5 articles (11/2015 - 10/2003)
3.	Travis, William D: 5 articles (08/2014 - 02/2011)
4.	Longacre, Teri A: 5 articles (08/2013 - 05/2008)
5.	Ronnett, Brigitte M: 5 articles (03/2009 - 10/2002)
6.	Adsay, N Volkan: 5 articles (07/2008 - 01/2002)
7.	Yatabe, Yasushi: 4 articles (10/2015 - 01/2007)
8.	Rusch, Valerie W: 4 articles (08/2014 - 02/2011)
9.	Ino, Kazuhiko: 4 articles (07/2013 - 10/2006)
10.	Mikami, Mikio: 4 articles (04/2011 - 04/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mucinous Adenocarcinoma:

1.	MucinsIBA 01/01/2014 - "Many studies put emphasis on mucinous adenocarcinoma containing mucin component ≥50%. " 01/01/2011 - "Our study proved the predominance of mixed mucinous adenocarcinomas with less than 50% extracellular mucin, followed by the pure mucinous type. " 07/01/2000 - "The purpose of this study was to correlate the mammographic and ultrasonographic findings of mucinous carcinoma with histologic features in different types and mucin rates. " 12/01/1998 - "In this study, we conclude that the altered expression of mucin so characteristic of colloid carcinoma is also a field change present in adjacent and remote normal breast epithelium." 10/01/2015 - "Mucinous adenocarcinomas from different primary sites are histologically identical with gland cells producing a copious amount of mucin. "
2.	Glycoproteins (Glycoprotein)IBA 03/01/2010 - "The expression of different MUC glycoproteins has helped define cellular lineage in variety of pancreatic neoplasms, and has helped identify distinct carcinogenic pathways such as the intestinal pathway characterized by diffuse/strong MUC2/CDX2 expression in intestinal-type intraductal papillary mucinous neoplasms (IPMNs) and their associated colloid carcinomas (CCs). " 08/01/1988 - "Colloid carcinoma, another variant of colonic carcinoma, showed prominent 13C resonances from glycoproteins, which were absent from the spectra of normal colon, and from spectra from the more common pattern of colonic adenocarcinoma. " 01/01/2004 - "The result indicated that the content of collagen protein and nucleic acid increased obviously in cancerous tissue, while the content of glycoprotein increased gradually except mucinous carcinoma. " 08/01/2001 - "Active specific immunotherapy with liposomal vaccines targeted to the mucinous carcinoma-associated glycoprotein MUC1 have shown promising results in animal models. " 10/01/2002 - "The findings here also support the previous impression that MUC2 (the mucin associated with gel formation) is a marker of the "indolent" pathway (intraductal papillary mucinous neoplasm and colloid carcinoma), whereas MUC1 (the glycoprotein known to have an inhibitory role in cell-cell and cell-stroma interactions as well as in immunoresistance of tumor cells) is a marker of the "aggressive" pathway (PanIN to ductal adenocarcinoma)."
3.	GastrinsIBA 10/01/1984 - "This study deals with the growth effect of gastrin on two xenotransplantable human gastric carcinomas (SC-6-JCK, poorly differentiated adenocarcinoma; and St-15, mucinous adenocarcinoma) and on one colonic carcinoma (Co-3, well-differentiated adenocarcinoma). " 06/01/1985 - "In week 35 prolonged administration of testragastrin in depot form from the beginning of MNNG-treatment resulted in a significant reduction in the incidence of colonic tumors and a significant increase in the incidence of mucinous adenocarcinoma, unlike the well-differentiated adenocarcinoma produced in controls without gastrin. "
4.	beta CateninIBA 11/15/2003 - "Immunohistochemical and mutational analyses of beta-catenin, Ki-ras, and p53 in two subtypes of colorectal mucinous carcinoma." 05/01/1999 - "All 4 cases exhibited mutations in exon 3 of beta-catenin, including a mucinous carcinoma. " 08/01/2003 - "To investigate whether localization of beta-catenin is helpful in differentiating primary ovarian mucinous carcinoma and colorectal adenocarcinoma metastatic to the ovary. " 08/01/2003 - "Immunostaining of beta-catenin is a useful marker for differentiating between ovarian mucinous carcinoma and metastatic colorectal adenocarcinoma." 08/01/2003 - "Although nuclear localization of beta-catenin was occasionally seen in non-mucinous carcinoma of the ovary and metastatic adenocarcinoma from other organs, such tumours were usually distinguishable by their clinicopathological picture and rarely raised diagnostic problems. "
5.	Fluorouracil (Carac)FDA LinkGeneric 03/01/2009 - "Exposure to 5-fluorouracil down-regulated cross-complementation group 1 expression in ovarian mucinous adenocarcinoma cells. " 07/01/2004 - "Therefore, for chemotherapy of mucinous adenocarcinoma, anticancer agents other than 5-FU should be selected." 07/01/2004 - "Thus, mucinous adenocarcinoma of the colon was more resistant to 5-FU than the differentiated adenocarcinoma. " 07/01/2004 - "The DPD activity of mucinous adenocarcinoma is related to catabolism of 5-FU is equal to that of adenocarcinoma, however, the OPRT activity is related to a main pathway of 5-FU phosphorylation is significantly lower. " 03/01/2009 - "We conclude that combination chemotherapy consisting of oxaliplatin and 5-fluorouracil was an effective treatment for ovarian mucinous adenocarcinoma and may be a pivotal candidate for a novel treatment strategy."
6.	Alcian BlueIBA 09/01/2006 - "Based on these findings, mucinous mammary carcinoma in the cat varies significantly from the human and canine varieties and alcian blue is the prominent stain in the diagnosis of feline mucinous carcinoma." 04/01/1994 - "The ages of the patients varied from 18 to 77 yr (mean 43.7 yr) and the male: female ratio was 2:1. PAS Alcian blue staining was helpful in differentiating mucinous from non-mucinous adenocarcinomas and reclassifying one poorly differentiated carcinoma as mucin secreting adenocarcinoma. " 01/01/2012 - "Ancillary tests with alcian blue/periodic acid Schiff and mucicarmine staining revealed that it was a mucinous adenocarcinoma. " 12/01/1998 - "We studied 50 colloid carcinomas, 50 noncolloid cancers, and 50 normal breasts by hematoxylin-eosin (H&E) and Alcian blue staining, mucin immunohistochemistry, in situ hybridization with a battery of MUC riboprobes, and ancillary digital image analysis. "
7.	oxaliplatin (Eloxatin)FDA LinkGeneric 03/01/2009 - "We conclude that combination chemotherapy consisting of oxaliplatin and 5-fluorouracil was an effective treatment for ovarian mucinous adenocarcinoma and may be a pivotal candidate for a novel treatment strategy." 03/01/2009 - "Combination chemotherapy of oxaliplatin and 5-fluorouracil may be an effective regimen for mucinous adenocarcinoma of the ovary: a potential treatment strategy." 03/01/2009 - "The combination of oxaliplatin and 5-fluorouracil significantly prolonged survival in a ovarian mucinous adenocarcinoma xenograft model of nude mice. " 01/01/2015 - "In this paper, we report the second case in the literature with primary mucinous adenocarcinoma of the bladder which showed complete response to FOLFOX4 (fluorouracil, leucovorin, oxaliplatin) chemotherapy regimen. " 01/01/2008 - "Experience with adjuvant chemotherapy for pseudomyxoma peritonei secondary to mucinous adenocarcinoma of the appendix with oxaliplatin/fluorouracil/leucovorin (FOLFOX4)."
8.	Methylnitronitrosoguanidine (MNNG)IBA 06/01/1985 - "In week 35 prolonged administration of testragastrin in depot form from the beginning of MNNG-treatment resulted in a significant reduction in the incidence of colonic tumors and a significant increase in the incidence of mucinous adenocarcinoma, unlike the well-differentiated adenocarcinoma produced in controls without gastrin. " 08/01/1990 - "The gastric and intestinal phenotypic expressions of tumor cells in 18 adenomatous hyperplasias, 33 well-differentiated adenocarcinomas, and 16 undifferentiated adenocarcinomas (4 poorly differentiated adenocarcinomas, 10 signet-ring cell carcinomas and 2 mucinous adenocarcinomas) induced by N-methyl-N'-nitro-N-nitrosoguanidine or 4-nitroquinoline-1-oxide in the rat glandular stomach were studied by histochemical stainings for mucin and immunohistochemical staining for pepsinogen isozyme 1 (Pg 1). "
9.	VaccinesIBA 08/01/2001 - "Active specific immunotherapy with liposomal vaccines targeted to the mucinous carcinoma-associated glycoprotein MUC1 have shown promising results in animal models. "
10.	panitumumab (Vectibix)FDA Link 07/01/2012 - "[A case report of advanced mucinous adenocarcinoma of the transverse colon with peritoneal dissemination effectively treated by multidisciplinary approach with a focus on FOLFOX4 therapy combined with panitumumab]." 07/01/2012 - "We found that a multidisciplinary approach with a focus on FOLFOX4 therapy combined with panitumumab is useful for patients with highly advanced mucinous adenocarcinoma of the colon that develops into peritoneal dissemination."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 10/01/2015 - "Complete cytoreduction with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) has been shown to improve survival in patients with low-grade mucinous adenocarcinoma (LGMA). " 03/01/2009 - "The present study aimed to identify an effective chemotherapy for ovarian mucinous adenocarcinoma. " 08/01/2015 - "Hyperthermic Intraperitoneal Chemotherapy Following Cytoreductive Surgery Improves Outcome in Patients With Primary Appendiceal Mucinous Adenocarcinoma: A Pooled Analysis From Three Tertiary Care Centers." 06/01/2014 - "The role of systemic chemotherapy (SC) in conjunction with cytoreductive surgery (CS) with hyperthermic intraperitoneal chemotherapy (HIPEC) in appendiceal mucinous carcinoma peritonei (MCP) is unknown. " 06/01/2014 - "Perioperative systemic chemotherapy for appendiceal mucinous carcinoma peritonei treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy."
2.	Lymph Node Excision (Lymph Node Dissection) 07/01/2013 - "Omission of systematic lymphadenectomy can be considered only for patients with mucinous carcinoma G1 level. " 01/01/2009 - "Right hemicolectomy with lymph node dissection and en-bloc partial resection of the adherent parietal wall was performed and the final pathology showed a moderately differentiated mucinous adenocarcinoma. " 03/01/2003 - "A left partial vulvectomy with bilateral inguinal lymph node dissections revealed a mucinous adenocarcinoma that involved the dermis and subcutaneous tissue. " 11/01/1988 - "The results suggest the need for aggressive lymph node dissection and wide excision of the surrounding tissues for mucinous carcinoma, with special attention paid to local recurrence." 04/01/2003 - "The survival rate could not be improved through retroperitoneal lymphadenectomy in the patients in early stage, advanced stage with residual tumor > 2 cm or those with mucinous adenocarcinoma (P > 0.05). "
3.	Adjuvant Chemotherapy 02/01/2014 - "This study demonstrates that adjuvant chemotherapy is an independent factor for improvement in overall survival in patients with mucinous adenocarcinoma. " 02/01/2014 - "Therefore, patients who have undergone TME surgery for mucinous carcinoma of the rectum should be offered adjuvant chemotherapy even in the absence of other high-risk features for poor outcomes." 02/01/2014 - "Adjuvant chemotherapy improves overall survival after TME surgery in mucinous carcinoma of the rectum." 01/01/2012 - "Additionally, extrapolating from data for mucinous adenocarcinomas, consideration could be given to adjuvant chemotherapy after appropriate staging (b). " 01/01/2002 - "A 15-year-old girl with Duke's B mucinous carcinoma of the rectosigmoid was treated with surgical resection and adjuvant chemotherapy. "
4.	Radiotherapy 07/01/2013 - "Here we present a rare case of primary mucinous adenocarcinoma of vagina treated successfully with wide local excision and post-operative radiotherapy. " 04/01/2014 - "Prostate mucinous carcinoma treated with definitive radiotherapy and hormonal therapy: case report and review of the literature." 05/01/2013 - "This case suggests that preoperative radiotherapy may play an important role in the definitive treatment of locally advanced perianal mucinous adenocarcinoma." 01/01/2011 - "We are reporting two cases with similar appearances on post chemo radiotherapy MRI scan of the mucinous adenocarcinoma. " 10/01/2004 - "The results were compared with data from the pre-irradiation biopsies and revealed the presence of two distinct classes of mucinous carcinoma in the radiotherapy group, namely pre-existing (un-induced; n = 24) and induced mucinous carcinoma (n = 29). "
5.	Combination Drug Therapy (Combination Chemotherapy) 03/01/2009 - "We conclude that combination chemotherapy consisting of oxaliplatin and 5-fluorouracil was an effective treatment for ovarian mucinous adenocarcinoma and may be a pivotal candidate for a novel treatment strategy." 03/01/2009 - "Combination chemotherapy of oxaliplatin and 5-fluorouracil may be an effective regimen for mucinous adenocarcinoma of the ovary: a potential treatment strategy." 01/01/2010 - "We report a case of advanced stage primary mucinous adenocarcinoma of the vagina that showed a highly aggressive course and resistance to combination chemotherapy with paclitaxel and carboplatin. " 09/01/2013 - "Combination chemotherapy of docetaxel and irinotecan may be a useful option to treat TC-refractory/resistant cases and primary clear cell and mucinous adenocarcinoma cases of ovarian carcinoma."