Walker Carcinoma 256

A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino rat, and which now resembles a carcinoma in young transplants and a sarcoma in older transplants. (Stedman, 25th ed)

Also Known As:

Networked: 96 relevant articles (0 outcomes, 5 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Osteolysis
3.	Neoplasm Metastasis (Metastasis)
4.	Hypercalcemia (Milk Alkali Syndrome)
5.	Ascites

Experts

1.	Epstein, O I: 1 article (09/2013)
2.	Dugina, J L: 1 article (09/2013)
3.	Yurlova, E I: 1 article (09/2013)
4.	Krylova, S G: 1 article (09/2013)
5.	Pereira, Márcio Roberto Pinho: 1 article (09/2012)
6.	Soares, Fabiana Pereira: 1 article (09/2012)
7.	Silva, Sônia Leite da: 1 article (09/2012)
8.	Ribeiro, Thyciana Rodrigues: 1 article (09/2012)
9.	Silva, Silvia Fernandes Ribeiro da: 1 article (09/2012)
10.	Targino, Thiago Sousa e Silva: 1 article (09/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Walker Carcinoma 256:

1.	Cytostatic AgentsIBA 10/01/1972 - "[Studies on the solid Walker-carcinosarcoma 256 in the rat during administration of cytostatics]." 01/01/1970 - "[Comparative studies of clinically equivalent doses of various cytostatic agents on the mouse Ehrlich ascites carcinoma and rat Walker carcinosarcoma 256 in vivo and in cell culture (in vitro)]."
2.	Fluorouracil (Carac)FDA LinkGeneric 01/01/1980 - "[Studies in vivo and in vitro on the influence of 5-fluorouracil and n'-(2'-furanidyl)-5-fluorouracil on the walker carcinosarcoma 256 in the rat (author's transl)]." 04/01/1981 - "The antitumor activity of this compound was superior to those of 5-FU and 1-(2-tetrahydrofuryl)-5-fluorouracil (Tegafur, Ftorafur) in the treatment of transplantable tumors, not only 5-FU-sensitive tumors such as adenocarcinoma 755, lymphosarcoma LS-1, and plasmacytoma X5563, but also 5-FU-resistant tumors such as Lewis lung carcinoma and Walker carcinosarcoma 256. "
3.	Methylene Chloride (Dichloromethane)IBA 07/01/1993 - "The purpose of this study was to investigate the influence of a prophylactic bone protective treatment with the bisphosphonate dichloromethane/diphosphonic acid (Cl2MBP) in an experimental model of osteolysis with intraosseous implantation of the Walker carcinosarcoma 256 B. "
4.	Mechlorethamine (Nitrogen Mustard)FDA Link 12/01/1966 - "The biology of large solid tumours regressing with nitrogen mustard treatment: a study of the mouse plasma cell tumour Adj-pc-5 and the Walker carcinosarcoma 256."
5.	Complement C5 (Complement 5)IBA 01/01/1984 - "In this paper we describe studies on the Walker carcinosarcoma 256, a rat mammary tumor which exhibits chemotactic responses to factors in the media of cultured resorbing bone and to a factor generated by proteolysis of the fifth component of serum complement (C5). "
6.	A-factor (Streptomyces)IBA 01/01/1984 - "In this paper we describe studies on the Walker carcinosarcoma 256, a rat mammary tumor which exhibits chemotactic responses to factors in the media of cultured resorbing bone and to a factor generated by proteolysis of the fifth component of serum complement (C5). "
7.	Parathyroid Hormone-Related ProteinIBA 10/21/1992 - "Isolation of a 18,000-Da molecular weight form of parathyroid hormone-related protein from the rat Walker carcinosarcoma 256." 02/01/1991 - "Osteolytic activity of Walker carcinosarcoma 256 is due to parathyroid hormone-related protein (PTHrP)." 01/01/1995 - "Effects of passive immunization against parathyroid hormone-related protein: PTHrP is the responsible factor in mediating hypercalcemia in the Walker carcinosarcoma 256 rat model." 05/01/1995 - "Walker carcinoma 256 (W256) was reported to induce hypercalcemia dependent on bone metastasis and/or parathyroid hormone-related protein (PTHrP) in the rat, providing a model of the humoral hypercalcemia of malignancy. " 04/01/1996 - "Glucocorticoids decrease the production of parathyroid hormone-related protein in vitro but not in vivo in the Walker carcinosarcoma 256 rat model."
8.	9,10-Dimethyl-1,2-benzanthracene (DMBA)IBA 01/01/1978 - "The compound in high doses was ineffective against the DMBA-induced rat mammary carcinoma and the following transplanted experimental tumors: Sarcoma 180, plasma cell tumor LPC-1, leukemia L1210, Mecca lymphosarcoma, Ridgway osteogenic sarcoma, sarcoma T241, mammary carcinoma E0771, Taper liver tumor, Ehrlich carcinoma (solid and ascites), and Walker carcinosarcoma 256. " 01/01/1980 - "Three new nitrosoureas and chlorozotocin were screened for anticancer activity against Walker carcinoma 256 and DMBA-induced mammary cancer of the rat. " 06/01/1967 - "Serum lipoproteins in rats with tumors induced by 9,10-dimethyl-1,2-benzanthracene and with transplanted Walker carcinosarcoma 256."
9.	alpha-ketoglutaric acid (alpha-ketoglutarate)IBA 04/12/1979 - "II. Increase of alpha-ketoglutarate in whole blood and urine and hypoalbuminemia of rats bearing the solid rhabdomyosarcoma BA 1112 and the ascitic or solid forms of Walker-carcinoma 256 and Yoshida-sarcoma." 11/01/1960 - "Changes in liver tyrosine-alpha-ketoglutarate transaminase activity during growth of Walker carcinosarcoma 256." 06/01/1958 - "Growth-promoting properties of pyruvate oxal-acetate, and alpha-ketoglutarate for isolated Walker carcinosarcoma 256 cells."
10.	Cytochromes c (Cytochrome c)IBA 10/01/1960 - "The effect of thyroxine on the cytochrome C content of tissues of rats bearing the Walker carcinosarcoma 256." 04/01/1958 - "Cytochrome c and myoglobin in rats bearing the Walker carcinosarcoma 256."

Therapies and Procedures

1.	Transplantation (Transplant Recipients) 01/01/1986 - "The bone metastases on SD rats were induced by intraarterial and intraosseous transplantation of Walker carcinosarcoma 256 B ascites cells. " 10/01/1992 - "Hypercalcemia was created by calcium infusions for 6 h, a high-calcium diet given to weanling rats for 3 weeks, and the transplantation of the Walker carcinosarcoma 256 cell line. "
2.	Lasers (Laser) 04/01/1984 - "The phototoxicity of acridine orange and argon laser irradiation on Walker carcinosarcoma 256 stomach tumors was studied. " 01/01/1988 - "The photodynamic inactivations of Walker carcinosarcoma 256 stomach tumors by the concomitant use of acridine orange (AO) and argon laser, and by the combined use of hematoporphyrin derivatives (HPD) and dye laser were compared. "
3.	Dye Lasers 01/01/1988 - "The photodynamic inactivations of Walker carcinosarcoma 256 stomach tumors by the concomitant use of acridine orange (AO) and argon laser, and by the combined use of hematoporphyrin derivatives (HPD) and dye laser were compared. "
4.	Transplants (Transplant) 09/01/1989 - "We have studied the effect of monocrotaline-induced lung injury on the retention and metastasis of intravenously injected Walker carcinosarcoma 256 cells in the lung and the effect of this injury on spontaneous metastasis in animals with intramuscular tumor transplants. "
5.	Protein-Restricted Diet (Diet, Protein Restricted) 03/01/1947 - "The inhibitory action of 1:2:5:6-dibenzanthracene on the growth of the Walker carcinoma 256 in rats maintained on high and low protein diets."