Carcinogens

Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.

Also Known As:

Networked: 5088 relevant articles (102 outcomes, 442 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hecht, Stephen S: 28 articles (07/2014 - 01/2002)
2.	Boffetta, Paolo: 26 articles (01/2015 - 08/2002)
3.	Hein, David W: 16 articles (01/2013 - 01/2002)
4.	Brennan, Paul: 12 articles (11/2015 - 08/2002)
5.	Tokuda, Harukuni: 12 articles (01/2008 - 02/2002)
6.	Caporaso, Neil E: 11 articles (01/2015 - 01/2002)
7.	Kromhout, Hans: 11 articles (01/2015 - 01/2003)
8.	Fukushima, Shoji: 11 articles (03/2013 - 05/2002)
9.	Nishino, Hoyoku: 11 articles (01/2008 - 02/2002)
10.	Bertazzi, Pier Alberto: 10 articles (01/2015 - 01/2008)

Related Diseases

1.	Neoplasms (Cancer) 11/01/1990 - "Examination of studies which successfully helped demonstrate cancer causation is suggested as a means of determining which epidemiologic methods are most fruitful and efficient at identifying human carcinogens." 09/01/2007 - "The anticarcinogenic effect of Allium vegetables including garlic is attributed to organosulfur compounds (OSC), which are highly effective in affording protection against cancer in animal models induced by a variety of chemical carcinogens. " 01/01/2002 - "Experimental administration of chemical carcinogens to various mammals is highly effective in inducing malignant tumors. " 01/01/2015 - "With information available from individual's genomic sequences, consideration of populations who may be at risk due to environmental exposure to carcinogens or how to optimize their cancer therapy regimens to enhance efficacy of the anticancer drugs appears to be an important field of study to benefit individuals in the future. " 12/01/1995 - "Rodent mammary tumors induced by chemical carcinogens have proven to be very useful in the genetic analysis of initiation, promotion and progression of mammary carcinogenesis. "
2.	Lung Neoplasms (Lung Cancer) 12/01/2009 - "The best protection against lung cancer is avoidance of airborne carcinogens and increased consumption of fruits and vegetables. " 04/01/1998 - "This review focuses on the range of techniques currently available for characterizing lung cancer and how their prudent use can be beneficial in the identification of occupational carcinogens. " 01/01/1975 - "The improvement in the quality of cigarettes, namely the reduction in the amount of carcinogens and its relation to the reduction of lung cancer death rates will be discussed. " 02/01/2014 - "Prospective, biomarker-based human studies on the role of PAH and other airborne carcinogens in the development of lung cancer among lifelong non-smokers have been lacking. " 01/01/2012 - "Our study indicates that previous exposure to occupational carcinogens remains an important determinant of lung cancer burden for Hong Kong Chinese men. "
3.	Carcinoma (Carcinomatosis) 01/01/1990 - "Carcinogens are not equally effective in all species and the histologic type of carcinoma that develops is strongly influenced by the species. " 05/17/2013 - "These studies have shown a decreased susceptibility to develop lung carcinomas induced by chemical carcinogens in Mmp1a(-/-) mice. " 04/01/2007 - "Recent studies have demonstrated that refluxed duodenal contents cause esophageal carcinoma in rats without exposure to carcinogens. " 08/01/2000 - "Recent studies have demonstrated that refluxed duodenal contents cause esophageal carcinoma in rats without exposure to carcinogens. " 09/01/1979 - "It could provide a model for further study of aspects of oesophageal carcinoma and it serves to remind us that all potential oesophageal carcinogens need not act during swallowing."
4.	Breast Neoplasms (Breast Cancer) 12/01/2010 - "The identification of occupations or occupational exposures associated with an increased incidence of breast cancer in men may help to identify mammary carcinogens in the environment. " 01/01/2015 - "Studies have shown that gene and environmental factors, such as BRCA1/2 mutations, ionized radiation, and chemical carcinogens, are related with breast cancer. " 02/08/2013 - "DNA mismatch repair (MMR) has been recently implicated to play a significant role in breast cancer progression, however, few studies have examined how various carcinogens affect MMR system in breast cancer cells. " 02/01/2011 - "These studies suggest that further research is needed to determine the role of carcinogens formed from cooking foods in inducing early molecular changes associated with breast cancer." 12/10/2010 - "In sum, the results of our study indicate that evaluation of the extent of cell proliferation and apoptosis before the onset of preneoplastic lesions may be a potential biomarker of breast cancer risk after exposure to breast carcinogens."
5.	Urinary Bladder Neoplasms (Bladder Cancer) 01/01/2012 - "Many epidemiological and experimental studies report a strong role of chemical carcinogens in the etiology of bladder cancer. " 06/01/2011 - "The significant excess of bladder cancer in the north part of France, with high manufacture concentration likely to have employees exposed to bladder carcinogens, has led us to study the influence of these exposures in the natural history of bladder cancer. " 10/01/2008 - "Experimental studies suggest that increased urination frequency may reduce bladder cancer risk if carcinogens are present in the urine. " 07/01/2006 - "After eliminating the effect of cigarette smoking on bladder cancer risk in our study population, the male-to-female incidence ratio decreased from 8.2 to 1.7, suggesting that nearly the entire male excess of bladder cancer observed in Spain is explained by cigarette smoking rather than occupational/environmental exposures to other bladder carcinogens." 06/01/2001 - "Our study investigated the risks of genotypes of N-acetyltransferase 2 (NAT2), tobacco use and/or occupational exposure to carcinogens in patients with bladder cancer and in age- and sex-matched controls in Japanese. "

Related Drugs and Biologics

1.	Enzymes
2.	Smoke
3.	9,10-Dimethyl-1,2-benzanthracene (DMBA)
4.	anthracene
5.	DNA (Deoxyribonucleic Acid)
6.	Mutagens
7.	Tea
8.	Benzoyl Peroxide
9.	Methylcholanthrene
10.	Antioxidants

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Transplantation (Transplant Recipients)
3.	Oral Administration
4.	Nephrectomy
5.	Subcutaneous Injections