Carbuncle

An infection of cutaneous and subcutaneous tissue that consists of a cluster of boils. Commonly, the causative agent is STAPHYLOCOCCUS AUREUS. Carbuncles produce fever, leukocytosis, extreme pain, and prostration.

Also Known As:

Networked: 65 relevant articles (3 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Cellulitis
2.	Infection
3.	Furunculosis (Boils)
4.	Abscess
5.	Sepsis (Septicemia)

Experts

1.	Ham, Inhye: 1 article (01/2015)
2.	Wang, Rui-Ping: 1 article (01/2015)
3.	Hu, Shou-You: 1 article (01/2015)
4.	Choi, Ho-Young: 1 article (01/2015)
5.	Shin, Min Sik: 1 article (01/2015)
6.	Lee, Kyungjin: 1 article (01/2015)
7.	Xie, Wei-Bing: 1 article (01/2015)
8.	Fang, Liang-Hua: 1 article (01/2015)
9.	Teng, Yu-Hao: 1 article (01/2015)
10.	Wu, Yan-Bin: 1 article (05/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Carbuncle:

1.	Penicillins (Penicillin)FDA Link 08/19/1955 - "[Carbuncle and penicillin]." 02/28/1954 - "[Endoarterial penicillin therapy of carbuncles of the extremities]." 07/01/1952 - "[Therapy of carbuncle of the neck by local penicillin injection]." 12/01/1951 - "Carbuncle treated by penicillin compress; report of a case." 04/01/1949 - "The Treatment of Carbuncles by the Local Injection of Penicillin."
2.	Anti-Bacterial Agents (Antibiotics)IBA 04/01/2013 - "The treatment of carbuncles is early administration of antibiotics and surgery. " 11/01/1986 - "Oral antibiotics and the renal carbuncle." 02/01/1985 - "During the years 1980-82 seven patients with renal carbuncles successfully underwent conservative treatment with antibiotics alone. " 01/01/2012 - "Antibiotics have a significant role in dermatology, treating a wide range of diseases, including acne, rosacea, inflammatory skin conditions and skin structure infections, such as cellulitis, folliculitis, carbuncles, and furuncles. " 09/01/1977 - "Renal carbuncles in seven young males were successfully treated with long-term administration of penicillinase-resistant antibiotics. "
3.	GlycopeptidesIBA 12/01/2010 - "A prudent clinician should be aware that, cloxacillin, the drug of choice for skin infections such as carbuncle and cellulitis, will not be effective in these cases and that community acquired MRSA has a range of antibiotics to choose from, other than the glycopeptides, when compared with that of hospital acquired MRSA."
4.	Cloxacillin (Tegopen)FDA Link 12/01/2010 - "A prudent clinician should be aware that, cloxacillin, the drug of choice for skin infections such as carbuncle and cellulitis, will not be effective in these cases and that community acquired MRSA has a range of antibiotics to choose from, other than the glycopeptides, when compared with that of hospital acquired MRSA."
5.	Cefadroxil (Duricef)FDA LinkGeneric 01/01/1976 - "Oral cefadroxil in doses of 0-6-1-8 g per day given on twice or three times daily schedules was effective in the treatment of thirty-six patients with infections such as abscesses, carbuncles, cellulitis, furunculosis and impetigo. "
6.	CoagulaseIBA 04/01/1996 - "A gram-positive coagulase-positive coccus was isolated from purulent drainage from the carbuncle of a pediatric patient. " 07/31/1965 - "In clinical studies with a new oral antibiotic, lincomycin, excellent results were obtained in the treatment of carbuncles, furuncles, folliculitis, cellulitis, lymphangitis, lymphadenitis, pyonychias and dermatitis infectiosa eczematoides due to coagulase-positive Staphylococcus aureus and to Streptococcus hemolyticus Type A. "
7.	Lincomycin (Lincocin)FDA Link 07/31/1965 - "In clinical studies with a new oral antibiotic, lincomycin, excellent results were obtained in the treatment of carbuncles, furuncles, folliculitis, cellulitis, lymphangitis, lymphadenitis, pyonychias and dermatitis infectiosa eczematoides due to coagulase-positive Staphylococcus aureus and to Streptococcus hemolyticus Type A. "
8.	Procaine (Novocaine)FDA LinkGeneric 07/01/1949 - "Procaine block and carbuncles." 02/01/1977 - "Under observation were 12 patients, in whom following paranephral novocain blockade subcapsular and paranephral hematomas, purulent paranephritis, abscesses and carbuncles of the kidneys developed. "
9.	CortisoneIBA 05/18/1951 - "[Dissecting carbuncle of the face, of torpid evolution, in a patient treated by cortisone]." 12/01/1965 - "[Cortisone and penicillin therapy of carbuncle]."
10.	Chlortetracycline (Aureomycin)FDA Link 07/01/1957 - "[Biomycin treatment in carbuncles and furuncluosis]." 08/01/1950 - "[Carbuncle of the lower lip; ascending phlebitis; penicillin resistance; cure by aureomycin]."

Therapies and Procedures

1.	Skin Transplantation (Skin Grafting) 12/01/2013 - "Excision of carbuncle with primary split-thickness skin grafting as a new treatment modality." 12/01/2013 - "This study is an attempt to cover the wounds resulting from excision of carbuncle with primary skin grafting so as to decrease the hospital stay and frequency of dressings. "
2.	Traditional Medicine (Folk Remedies) 03/08/2011 - "Thladiantha dubia (Cucurbitaceae) has been used in Chinese manchu nationality folk medicine for treatment of various diseases, such as scrofula, carbuncle, lactation deficiency, etc. Its effects include softening hard masses, heat-clearing and detoxifying, reducing swelling, eliminating carbuncle, and promoting lactation. " 08/13/2008 - "(Leguminosae) have been used in traditional medicine for the treatment of inflammatory diseases including swelling, suppuration, carbuncle and skin diseases in China and Korea. " 12/01/1959 - "[Treatment of furuncle, carbuncle and suppurative wounds by traditional medicine: a preliminary report on 500 cases]." 10/11/2011 - "Sipunculus nudus has long been employed as traditional Chinese medicine in folk remedies for the treatment of carbuncles, tuberculosis and nocturia, regulating the functions of stomach and spleen, as well as for the restoration to health in debilities caused by various pathogens and aging. " 05/28/2014 - "(TSL), a popular vegetable in China, have anti-inflammatory, antidoting, and worm-killing effects and are used in folk medicine for the treatment of enteritis, dysentery, carbuncles, boils, and especially abdominal tumors. "
3.	Transplants (Transplant) 05/24/1964 - "[TRANSPLANTATION OF HALF-THICKNESS SKIN GRAFTS FOLLOWING THE EXCISION OF CARBUNCLES]." 01/01/1980 - "renal arterial or venous thrombosis, ureteral occlusion, failure of ureterocystoanastomosis, acute renal failure, infarct, carbuncle or abscess of the transplant, acute rejection, rupture of the transplanted kidney. "
4.	East Asian Traditional Medicine (Oriental Medicine) 01/30/2013 - "Taglisodog-eum (Tuo Li Xiao Du Yin), a standardized herbal formula, has been widely used to modulate diverse carbuncles in oriental medicine. " 04/01/2013 - "The thorns of Gleditsia sinensis are a traditional Oriental medicine used for the treatment of swelling, suppuration, carbuncle and skin diseases. "
5.	Chinese Traditional Medicine (Traditional Chinese Medicine) 06/28/2001 - "To differentiate and type the acne vulgaris patients and to treat them with our own recipes for dissipating heat and detoxifying in traditional Chinese medicine 148 cases were typed and trated as: carbuncles and stasis (84 cases), carbuncles and damp 'toxins' (16) and damp 'toxins' and stasis (48) as well as the contrast groups of 60 patients that treated with chemical medicines. " 10/11/2011 - "Sipunculus nudus has long been employed as traditional Chinese medicine in folk remedies for the treatment of carbuncles, tuberculosis and nocturia, regulating the functions of stomach and spleen, as well as for the restoration to health in debilities caused by various pathogens and aging. "