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Carboxymethylcellulose Sodium (Polycell)

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A cellulose derivative which is a beta-(1,4)-D-glucopyranose polymer. It is used as a bulk laxative and as an emulsifier and thickener in cosmetics and pharmaceuticals and as a stabilizer for reagents.

Also Known As:

Polycell; Carboxymethyl Cellulose; Croscarmellose Sodium; Ruspol; Sodium Carboxymethylcellulose; Aquacel; Aquaplast; Carmellose Sodium; Cellolax; Cethylose; Carboxymethylcellulose, Sodium; Cellulose, Carboxymethyl; Sodium, Carboxymethylcellulose; Sodium, Carmellose; Sodium, Croscarmellose; Carboxymethylcellulose

Networked: 452 relevant articles (34 outcomes, 84 trials/studies)

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Drug Context: Research Results

Experts

1.	Salazar, Andres M: 8 articles (01/2016 - 01/2007)
2.	Ernsting, Mark J: 6 articles (05/2015 - 12/2011)
3.	Li, Shyh-Dar: 6 articles (05/2015 - 12/2011)
4.	Okada, Hideho: 5 articles (07/2014 - 01/2007)
5.	Undzys, Elijus: 4 articles (05/2015 - 05/2012)
6.	Walker, M: 4 articles (01/2015 - 02/2003)
7.	diZerega, Gere S: 3 articles (10/2015 - 07/2003)
8.	Simmons, Peter A: 3 articles (01/2015 - 11/2004)
9.	Lin, Sin-Daw: 3 articles (05/2014 - 02/2008)
10.	Wu, Sheng-Hua: 3 articles (05/2014 - 02/2008)

Related Diseases

1.	Burns 08/01/2010 - "This study confirms the efficacy of Aquacel Ag for the treatment of partial thickness burns at an outpatient clinic." 02/01/2015 - "Efficacy of aquacel Ag dressing in the treatment of deep burns in children." 05/01/2014 - "Aquacel(®) Ag dressing versus Acticoat™ dressing in partial thickness burns: a prospective, randomized, controlled study in 100 patients. " 11/01/2012 - "This study evaluated the AQUACEL(®) Ag BURN glove for the management of hand burns. " 08/01/2010 - "The purpose of this study was to show the benefits of Aquacel Ag for the treatment of partial thickness burns. "
2.	Infection 01/01/2014 - "In this study, a rat model with carboxymethyl cellulose pouch infection was used to analyze the efficacy of bone marrow-derived mesenchymal stromal cells (BMSCs) against the methicillin-resistant Staphylococcus aureus. " 11/01/2015 - "Aquacel Ag needed to be replaced more often and represented the only three donor site infections. " 11/01/2015 - "Three patients developed donor site infections with Aquacel Ag. " 04/01/2015 - "The Aquacel Ag group was only able to show significantly better wound healing than the infection group (p < 0.001). " 11/01/2011 - "Three donor sites showed clinical signs of infection (two Glucan II and one Aquacel Ag) prompting culture and dressing removal. "
3.	Wounds and Injuries (Trauma) 11/01/2007 - "Silvercel was found to be significantly more effective in terms of wound exudate management than Aquacel Ag. " 01/01/2010 - "Clinical studies confirmed that Aquacel Ag((R)) is an effective and safe dressing for a variety of wound types, both acute and chronic. " 04/01/2015 - "In this study, we created a novel incisional SSI model and validated it in terms of both macroscopic and microscopic aspects including its response to treatment using antimicrobial wound-dressing, Aquacel Ag(®). " 08/01/2014 - "Results of a prospective, randomized, controlled study of the use of carboxymethylcellulose sodium hyaluronate adhesion barrier in trauma open abdomens." 05/01/2008 - "In the Galdakao Hospital during 2006 and early 2007, medical personnel carried out a study to evaluate the effectiveness of a Aquacel wet cure dressing (Hydrofiber Technology, ConvaTec, Bristol-Myers Squibb) in treatment for secondary wounds after surgery to deal with Dupuytren pathology. "
4.	Neoplasms (Cancer) 06/01/1979 - "Killed BCG cells suspended in 1.5% carboxymethylcellulose cured guinea pigs with established line 10 tumors in a high percentage of cases. " 01/01/2005 - "This study evaluated the image quality, the penetration depth, the tumor staging accuracy, and the safety of C-EUS by using carboxymethylcellulose, an edible, nontoxic, transparent jelly-like substance (JC-EUS). " 09/01/2014 - "Data revealed that carboxymethylcellulose allowed for a cell-extracellular matrix relationship typically believed to be present in tumors, with cells exhibiting a rounded, amoeboid morphology consistent with chemotactic migration, while the other matrices promoted an elongated cell shape as well as both haptotactic and chemotactic motile processes. " 02/01/2012 - "The aim of this report was to describe the computed tomography features of injected carboxymethylcellulose and how it can be mistaken for tumor recurrence. " 06/01/1979 - "The bacterial preparation of BCG in carboxymethylcellulose displayed a stronger tumor regressive activity and the process of healing was accelerated when endotoxin from a rough (Re) strain of Salmonella typhimurium was added to the BCG bacilli."
5.	Cicatrix (Scar) 07/01/1991 - "Of the remaining four agents, one of which was the unmodified carboxymethylcellulose, none showed significant reduction in scar tissue formation. " 05/01/2012 - "Scar quality improved in the Aquacel(®) Ag treatment group. " 08/01/2004 - "Final scarring (ie, after the 1-year follow-up) was significantly better with the Aquacel dressing. " 07/01/1991 - "Viscous carboxymethylcellulose in the prevention of epidural scar formation." 07/01/1991 - "These findings indicate that viscous preparations of modified carboxymethylcellulose can act as a barrier against epidural scar formation following laminectomy."

Related Drugs and Biologics

1.	Lysine (L-Lysine)
2.	poly ICLC
3.	Poly I-C
4.	Hyaluronic Acid (Hyaluronan)
5.	Silver
6.	alginic acid (sodium alginate)
7.	Interferons
8.	Petrolatum (Vaseline)
9.	Sodium
10.	Silver Sulfadiazine (SSD)

Related Therapies and Procedures

1.	Ovariectomy (Oophorectomy)
2.	Hepatectomy
3.	Curettage
4.	Injections
5.	Transplants (Transplant)