Carbadox

An antibacterial agent that has been used in veterinary practice for treating swine dysentery and enteritis and for promoting growth. However, its use has been prohibited in the UK following reports of carcinogenicity and mutagenicity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p125)

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Networked: 54 relevant articles (8 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	He, Yijie: 2 articles (01/2022 - 03/2021)
2.	Jinno, Cynthia: 2 articles (01/2022 - 03/2021)
3.	Kim, Kwangwook: 2 articles (01/2022 - 03/2021)
4.	Kovanda, Lauren: 2 articles (01/2022 - 03/2021)
5.	Li, Xunde: 2 articles (01/2022 - 03/2021)
6.	Liu, Yanhong: 2 articles (01/2022 - 03/2021)
7.	Allen, Heather K: 2 articles (01/2014 - 01/2014)
8.	Stanton, Thaddeus B: 2 articles (01/2014 - 01/2014)
9.	Bravo, David: 1 article (01/2022)
10.	Cox, Eric: 1 article (01/2022)

Related Diseases

1.	Dysentery 03/01/1973 - "Therapeutic efficacy of carbadox in field outbreaks of swine dysentery." 01/01/1987 - "Studies on the efficacy of Getroxel against Treponema hyodysenteriae and its role in the control of swine dysentery." 02/01/1973 - "Efficacy of carbadox in prevention of field outbreaks of swine dysentery." 08/15/1990 - "Carbadox is a potentially effective prophylactic feed additive for the prevention of swine dysentery, but is mostly used in high dosages which are almost toxic for the animals, and used during unnecessary prolonged periods. " 01/01/1988 - "The carbadox levels encountered in the proximal part of the gut (stomach, duodenum) however, seem to indicate that in-feed administration of 50 ppm carbadox can provide an effective prophylaxis against Treponema hyodysenteriae, a causative agent in swine dysentery. "
2.	Weight Gain 01/01/1975 - "3. Mecadox stimulated weight gain in treated animals during the first 15 days of treatment. " 06/01/1987 - "Dietary supplementation of carbadox, but not vitamin C, produced significantly greater weight gain, feed efficiency, and spleen weight of pigs in both trials. " 11/01/2015 - "Carbadox (CBX) and olaquindox (OLA) were used in poultry and swine feed for growth promotion, to improve feed efficiency and increase the rate of weight gain. " 02/01/1990 - "Average weekly weight gain was significantly decreased in the higher carbadox and olaquindox groups. " 02/01/1990 - "An experiment was designed to study the clinical effects of different levels of carbadox, cyadox and olaquindox in the ration on health, weekly weight gain and feed conversion in pigs. "
3.	Infections 10/01/1977 - "Furazolidone and carbadox, as feed additives, were only partially effective for the treatment of experimentally induced infections of Salmonella choleraesuis var kunzendorf in swine. " 01/01/1981 - "Under the conditions of these studies, carbadox and carbadox + sulfamethazine proved to be the most effective agents in preventing SD during the infection + medication and postmedication periods. " 03/15/1979 - "Carbadox in combination with sulfamethazine did not interfere with the activity of sulfamethazine in clearing experimentally induced Bordetella bronchiseptica nasal infection. " 01/01/1976 - "[Comparative studies of the therapeutic value of metronidazole and carbadox in flagellata infections of mice]." 04/01/1988 - "hyodysenteriae ranged from 0.78 to 12.5 micrograms/ml, the MIC for 90% of the strains tested (MIC90) being 3.13 micrograms/ml. The protective and therapeutic effects of sedecamycin were compared with those of carbadox, tiamulin, and lincomycin against experimental infection with T. "
4.	Enteritis 10/01/1976 - "Carbadox administered in the dose of 50 mg per 1 kg of feed suppressed the signs of enteritis in comparison with the control piglets, significantly increased body weight gains, and reduced feed consumption to 1.9 kg per 1 kg of gain. " 01/01/2014 - "Carbadox is a veterinary antibiotic used in the US during the starter phase of swine production for improved feed efficiency and control of swine dysentery and bacterial swine enteritis. " 01/01/2015 - "For the treatment of rabbit dysentery and bacterial enteritis, veterinary practitioners often adopt veterinary medicinal products authorised for other food-producing species, but in some cases non-authorised drugs frequently used in the past, such as carbadox and olaquindox, might be illegally adopted. " 04/01/2009 - "Carbadox (CBX) and olaquindox (OLQ) are used in swine feed for growth promotion, to improve feed efficiency, increase the rate of weight gain, control swine dysentery and bacterial enteritis in young swine. "
5.	Body Weight (Weight, Body) 05/01/1983 - "Forty female and ten male pigs were used to study the effect of carbadox on reproductive performance when included in the diet at a level of 55 mg/kg from one week of age through approximately 60 kg body weight. " 03/01/2021 - "Weaned pigs (n = 34, 6.88 ± 1.03 kg body weight [BW]) were individually housed in disease containment rooms and randomly allotted to one of the three dietary treatments: nursery basal diet (CON) and two additional diets supplemented with 0.5 or 50 mg/kg carbadox to the nursery basal diet (TRA or REC), respectively. " 01/01/1986 - "The effect of Carbadox on growth performance could be observed from 20 to 60 kg body weight and over the whole experimental period from 20 to 90 kg. The increase of growth performance could be largely explained by a better digestibility of the nutrients." 08/01/1985 - "Individually penned pigs were fed ad libitum (expt 1) or pair-fed (expt 2 through expt 5) for either 2 (expt 1 through expt 4) or 3 (expt 5) wk. Mean body weight gain and gain/feed values were significantly (P less than 0.05) greater in pigs fed carbadox (a synthetic antimicrobial). " 05/01/1983 - "The effect of carbadox on reproduction when fed to Swine up to 60 kilograms body weight."

Related Drugs and Biologics

1.	Lincomycin (Lincocin)
2.	Ascorbic Acid (Vitamin C)
3.	Anti-Bacterial Agents (Antibiotics)
4.	Tylosin
5.	Virginiamycin
6.	Penicillins (Penicillin)
7.	Oxytetracycline (Terramycin)
8.	Furazolidone (Furoxone)
9.	Chlortetracycline (Aureomycin)
10.	Ronidazole