Captan

One of the phthalimide fungicides.

Also Known As:

N-Trichloromethylthio-4-cyclohexane-1,2-dicarboximide; Vancide 89; N Trichloromethylthio 4 cyclohexane 1,2 dicarboximide; 1H-Isoindole-1,3(2H)-dione, 3a,4,7,7a-tetrahydro-2-((trichloromethyl)thio)-

Networked: 49 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoindoles: 18
      - Captan: 49
        captafol: 18
        tetrahydrophthalimide

Experts

1.	Agrawal, S C: 4 articles (01/2007 - 01/2004)
2.	Gupta, S: 4 articles (01/2007 - 01/2004)
3.	Harris, Mark A: 3 articles (01/2020 - 12/2017)
4.	Thompson, Chad M: 3 articles (01/2020 - 12/2017)
5.	Alavanja, Michael C R: 2 articles (10/2020 - 12/2008)
6.	Koutros, Stella: 2 articles (10/2020 - 12/2008)
7.	Sandler, Dale P: 2 articles (10/2020 - 01/2010)
8.	Proctor, Deborah M: 2 articles (01/2020 - 12/2017)
9.	Hoppin, Jane A: 2 articles (01/2010 - 12/2008)
10.	He, Quan-Kuo: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2008 - "No association between the highest tertile of captan exposure (>67.375 intensity-weighted days) and development of all cancers (RR = 0.89; 95% CI, 0.71-1.13) or cancer of any specific site was observed. " 12/01/2008 - "We investigated risk for all cancers combined and sites of cancer for which at least 15 cases occurred among captan-exposed applicators. " 12/01/2008 - "Poisson regression analysis was used to estimate relative risks (RR) for cancer subtypes by tertiles of captan exposure. " 03/01/1989 - "Captan induced neoplasms of the duodenum in male and female mice. " 03/01/1989 - "Increased incidences of benign and malignant neoplasms, and of malignant neoplasms only, were observed in the reproductive system of female rats ingesting captan. "
2.	Infections 08/22/2023 - "Overall, our findings showed that application of doses less than the fungicide label dose, mixture with the low-risk fungicide captan, and application post-infection seem to be the most effective management strategies in our controlled experimental settings. " 02/01/2013 - "The captan treated fruits recorded the least infection of A. " 07/01/2001 - "The effectiveness of reduced fungicide programs, using either extended application intervals or alternate-row middle (ARM) spraying of wettable sulfur or captan, on infection of peach fruit by Cladosporium carpophilum was investigated in a 2-year study in Georgia. " 08/22/2023 - "Post-Infection Application of Fenhexamid at Lower Doses in Conjunction with Captan Slowed Fungicide Resistance Selection in Botrytis cinerea on Detached Grape Berries." 07/01/1997 - "In laboratory experiments, infection in segments of strawberry runners treated with pro-chloraz-Zn reached 60%, which was significantly reduced as compared to combined prochloraz-Zn/folpet (90%), captan, folpet, and water controls (100%). "
3.	Chromosome Aberrations (Chromosome Abnormalities) 05/01/1978 - "In in vivo cytogenetic study, no chromosomal aberrations were induced in the bone marrow cells of rats treated orally with captan at a single dose of 500, 1000 or 2000 mg/kg or at five consecutive doses of 200, 400 or 800 mg/kg/day. " 05/01/1978 - "In vitro cytogenetic study with cultured human diploid cells revealed a significant increase in the frequency of cells showing stickiness and a severe mitotic inhibition at concentrations of 3.0 and 4.0 microgram of captan per ml. although no chromosomal aberrations were observed. " 06/01/1980 - "A significant and dose-dependent increase in the frequency of SCEs and chromosomal aberrations was observed in the cell cultures treated with captan, captafol, EDB, DBCP, HEH, DDVP, vamidothion, DAPA or N-nitroso-ETU or NBT produced a significant increase in the frequency of polyploid cells, whereas the other agents did not. "
4.	Hyperplasia 06/01/2017 - "Major adverse effects of captan were observed in suppressed body weight, and also in duodenal mucosal hyperplasia in mice. " 09/01/2007 - "The new cancer classification considers captan to be a potential carcinogen at prolonged high doses that cause cytotoxicity and regenerative cell hyperplasia. " 10/01/2019 - "330:48-52), we showed that B6C3F1 mice exposed to carcinogenic concentrations of Cr(VI), captan, or folpet for 28 days exhibited similar histopathological responses including villus enterocyte cytotoxicity and regenerative crypt epithelial hyperplasia. " 01/01/2020 - "An adverse outcome pathway for small intestinal tumors in mice involving chronic cytotoxicity and regenerative hyperplasia: a case study with hexavalent chromium, captan, and folpet."
5.	Dehydration (Water Stress) 01/01/2007 - "However, a sharp fall in the cell gliding period, gliding cell percentage and speed occurred at various levels (different from cell survival period and percentage) in both diatoms in a similar extent under water stress (2, 4 and 6 % agarized supernatant, liquid supernatant with 0.2-1.0 mol/L NaCl, blot-dryness of cells for 5-15 min), pH extreme of liquid supernatant (< or =5.0, > or =9.0), temperature extremes in liquid supernatant (< or =15, > or =40 degrees C), UV exposure (0.96-5.76 kJ/m2), lack of all nutrients from the medium (double distilled water), darkness or low light intensities (2 and 10 micromol m(-2) s(-1)), presence of 'heavy' metals (Ni, Cu, Zn, Co, Fe, Hg; 1-200 ppm), organic substances in liquid supernatant (DDT, captan, urea, 2,4-D, 100-2000 ppm; thiourea, 50-1000 ppm). " 01/01/2006 - "water stress (2-8% agarized media, liquid media with 0.2-1 mol/L NaCl, blot-dryness of filaments for > or = 5 min), temperature shock (5, 40 degrees C for > or = 5 min; 35 degrees C for > or = 15 min), darkness and low light intensity (2, 10 micromol m(-2) s(-1)), UV exposure (0.96-3.84 kJ/m2), pH extremes (< or = 6.5 and > or = 9.5), lack of all nutrients from liquid medium (double distilled water), presence of 'heavy' metals (1, 25 ppm Fe, Cu, Zn, Ni, Co, Hg) or organic substances in liquid medium (25, 250 ppm 2,4-D, captan, urea, DDT, thiourea). " 01/01/2005 - "Water stress (2 and 4 % agarized puddle water, puddle water with 0.2-1 mol/L NaCl), temperature shock (< or = 10 degrees C, > or = 30 degrees C), darkness and low-light intensity, UV exposure (0.96-2.88 kJ/m2), pH extremes (< or = 6.5 and > or = 10), presence of 'heavy' metals (1-100 ppm Fe, Cu, Zn, Co, Ni, Hg) or organic substances in puddle water (25-1000 ppm 2,4-D, captan, urea, DDT, thiourea), all these factors rapidly (after 5 to 30 min) decreased the speed of the elongated motile form to < or = 300 microm/min, and induced all morphological changes leading to formation of round motile and round nonmotile forms. " 01/01/2004 - "However, factors such as water stress (2 and 4 % agarized media, liquid media with 0.2-0.4 mol/L NaCl, 5-60 min blot-dryness of filaments), pH extremes of liquid media (at < or =6.5 and > or =9.5), temperature shock in liquid media (5 and 35 degrees C for > or =5 min), UV exposure (0.96-3.84 kJ/m2), lack of all nutrients from liquid medium (double distilled water), darkness, and presence of "heavy" metals (1-25 ppm Cu, Fe, Zn, Hg, Ni, Co) or organic substances (200-600 ppm captan or DDT, 800 and 1000 ppm 2,4-D, 50 and 400 ppm indole-3-acetic acid (3-IAA), 1000 and 2000 ppm urea, 100 and 200 ppm thiourea) in liquid media decreased and/or delayed at various levels either zoosporangia survival, zoospore formation or zoosporangia dehiscence and/or the rate of zoospore liberation from zoosporangia, zoospore speed and time period of motility in the media or totally inhibited all these processes. "

Related Drugs and Biologics

1.	Pesticides
2.	Sulfur
3.	folpet (Phaltan)
4.	Heavy Metals
5.	Urea (Carbamide)
6.	Thiourea
7.	DDT
8.	captafol
9.	2,4-Dichlorophenoxyacetic Acid (2,4 Dichlorophenoxyacetic Acid)
10.	chromium hexavalent ion