Cantharidin (Cantharides)

A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.

Also Known As:

Networked: 403 relevant articles (19 outcomes, 56 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chung, Jing-Gung: 9 articles (09/2015 - 11/2010)
2.	Li, Wei: 8 articles (11/2015 - 05/2010)
3.	Tao, Min: 7 articles (11/2015 - 05/2011)
4.	Gong, Fei-Ran: 6 articles (11/2015 - 11/2011)
5.	Efferth, Thomas: 6 articles (02/2014 - 03/2005)
6.	Hsu, Shu-Chun: 5 articles (09/2015 - 07/2014)
7.	Morrell, Dean S: 5 articles (07/2014 - 03/2009)
8.	Han, Xiao: 5 articles (11/2011 - 09/2008)
9.	Wu, Meng-Yao: 4 articles (11/2015 - 08/2014)
10.	Hsia, Te-Chun: 4 articles (09/2015 - 11/2010)

Related Diseases

1.	Warts (Wart) 06/01/2014 - "The majority of studies show that cantharidin is an effective and safe treatment for removal of warts and MC. " 01/01/2009 - "Cantharidin is safe and effective when applied to flat warts without occlusion for 4-6 hours every 3 weeks till clear." 01/01/2009 - "Topical cantharidin has been reported to be effective and safe in the treatment of cutaneous warts but it has not previously been used for the treatment of facial flat warts. " 07/01/1960 - "-six per cent of digital warts and 33 per cent of periungual warts cleared after a single application of cantharidin. " 01/01/2009 - "Cantharidin treatment for recalcitrant facial flat warts: a preliminary study."
2.	Molluscum Contagiosum 03/01/2009 - "The results contribute to the data supporting cantharidin as a safe and effective treatment of molluscum contagiosum. " 08/01/1979 - "Cantharidin in either a 0.9% or 0.7% solution is a safe and effective office treatment for molluscum contagiosum. " 07/01/2014 - "Cantharidin for the treatment of molluscum contagiosum: a prospective, double-blinded, placebo-controlled trial." 03/01/2015 - "The utility of cantharidin for the treatment of molluscum contagiosum." 07/01/2014 - "Safety of cantharidin: a retrospective review of cantharidin treatment in 405 children with molluscum contagiosum."
3.	Blister (Bulla) 01/01/2012 - "Below we describe the materials and methods required to prepare, induce, aspirate and analyse the forearm cantharidin blisters, in preparation for future study design. " 07/01/2003 - "We report the blister induction technique and resolution time in ten volunteers enrolled in a pharmacokinetic study using the cantharidin-induced inflammatory blister technique." 01/01/2002 - "The cantharidin blister method was used to study the permeability of capillary vessels. " 06/01/1988 - "The mode of action of cantharidin, the natural vesicant of blister beetles, is examined by radioligand binding studies with mouse tissues. " 01/01/1969 - "3. Enzyme studies of the blister substance in cantharidin blisters]."
4.	Hepatocellular Carcinoma (Hepatoma) 12/01/2010 - "[Efficacy of cantharidin combined with transcatheter arterial embolization for primary hepatocellular carcinoma]." 09/01/2010 - "In this study, synthetic cantharidin analogues with a structure of aminothiazole compounds 3-9 and a structure of anhydride compounds 10-12 were screened for anticancer activities and cytotoxic effects on human hepatocellular carcinoma cell (HCC) lines HepG2, Sk-Hep1, and primary cultured rat hepatocytes. " 01/01/2014 - "Cantharidin exerts anti-hepatocellular carcinoma by miR-214 modulating macrophage polarization." 06/01/2013 - "Cantharidin (CTD), a natural toxin, can inhibit a variety of tumor cell lines, especially hepatocellular carcinoma cells. " 12/01/2006 - "A synthetic analogue of cantharidin (CAN 037) has been shown to have cytotoxic effect on the SK-Hep 1 hepatoma cell line but its underlying working principle remains undefined. "
5.	Pain (Aches) 08/01/2009 - "Topical cantharidin applications are used for the treatment of severe chronic lumbar pain in traditional European medicine (TEM). " 07/01/2009 - "Ninety-two percent of respondents reported satisfaction with cantharidin's efficacy, but 79% reported side effects, with discomfort/pain and blistering being the most common. " 04/01/2006 - "The case and the potential of topical cantharidin in pain syndromes are discussed." 04/01/2006 - "The multimodal CAM treatment resulted in a rapid clinical and x-ray resolution of pneumonia, and cantharidin treatment effectively relieved pain. " 08/01/2009 - "In this first study on the efficacy of cantharidin blisters, a clinically relevant pain-relieving short-term effect on LSS was observed. "

Related Drugs and Biologics

1.	Sodium
2.	norcantharidin
3.	Doxorubicin (Adriamycin)
4.	Nitrogen
5.	Salicylic Acid (2 Hydroxybenzoic Acid)
6.	Podophyllotoxin (Condylox)
7.	Camptothecin
8.	Mitomycin (Mitomycin-C)
9.	Silicon Dioxide (Sand)
10.	Irritants (Vesicants)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Ambulatory Care (Outpatient Care)
3.	Cryotherapy (Therapy, Cold)
4.	Therapeutics
5.	Heterologous Transplantation (Xenotransplantation)