Cantharidin (Cantharides)

A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.

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Networked: 597 relevant articles (34 outcomes, 100 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chung, Jing-Gung: 13 articles (10/2019 - 11/2010)
2.	Li, Wei: 12 articles (02/2021 - 05/2010)
3.	Tao, Min: 11 articles (02/2021 - 05/2011)
4.	Gong, Fei-Ran: 10 articles (02/2021 - 11/2011)
5.	Zhang, Yalin: 8 articles (12/2021 - 12/2013)
6.	Wu, Meng-Yao: 8 articles (02/2021 - 08/2014)
7.	Chen, Kai: 7 articles (02/2021 - 11/2011)
8.	Liu, Liang: 6 articles (11/2020 - 07/2018)
9.	Zhang, Youyou: 6 articles (11/2020 - 07/2018)
10.	Huang, Yi-Ping: 6 articles (10/2019 - 01/2013)

Related Diseases

1.	Molluscum Contagiosum 03/01/2009 - "The results contribute to the data supporting cantharidin as a safe and effective treatment of molluscum contagiosum. " 05/01/2021 - "An Efficacy of Cantharidin Treatment in Facial Molluscum Contagiosum in Younger Children: A Prospective Interventional Study in 67 Children." 08/01/2018 - "Safety and efficacy of topical cantharidin for the treatment of pediatric molluscum contagiosum: a prospective, randomized, double-blind, placebo-controlled pilot trial." 03/01/2021 - "Video abstract: Pooled Results of Two Randomized Phase III Trials Evaluating VP 102, a Drug Device Combination Product Containing Cantharidin 0.7% (w/v) for the Treatment of Molluscum Contagiosum (MP4 131293 KB)." 07/01/2014 - "Cantharidin for the treatment of molluscum contagiosum: a prospective, double-blinded, placebo-controlled trial."
2.	Warts (Wart) 12/01/2018 - "Significant clearance of warts with maintenance of clearance was demonstrated with topical cantharidin alone. " 06/15/2014 - "The majority of studies show that cantharidin is an effective and safe treatment for removal of warts and MC. " 01/01/2009 - "Cantharidin is safe and effective when applied to flat warts without occlusion for 4-6 hours every 3 weeks till clear." 01/01/2009 - "Topical cantharidin has been reported to be effective and safe in the treatment of cutaneous warts but it has not previously been used for the treatment of facial flat warts. " 03/01/2018 - "In this article, we present a case of a recalcitrant plantar wart that appeared to circumferentially spread from the initial site after first-line treatment and presumed resolution with the product cantharidin. "
3.	Neoplasms (Cancer) 01/01/2023 - "Previous studies showed that cantharidin had satisfactory pharmacological activity on a variety of tumors. " 09/01/2018 - "Several studies have shown that cantharidin has a cytotoxic effect on various cancer cells. " 01/01/2023 - "Cantharidin (CTD) is a highly toxic substance which can be used to treat a variety of cancers. " 11/25/2022 - "Cantharidin (CTD) has been traditionally used in Chinese medicine to induce apoptosis and inhibit cancer cell proliferation; however, the mechanism by which CTD inhibits cell proliferation remains unclear. " 01/01/2021 - "Meanwhile, cantharidin inhibited tumor growth in xenograft-bearing mice with 143B cell injection in tibia. "
4.	Hepatocellular Carcinoma (Hepatoma) 12/01/2010 - "[Efficacy of cantharidin combined with transcatheter arterial embolization for primary hepatocellular carcinoma]." 05/01/2016 - "The present study was designed to investigate the effect of cantharidin on cell proliferation, ability of selfrenewal, cell cycle arrest and induction of apoptosis in HepG2 hepatocellular carcinoma stem cells (HCSCs). " 11/28/2023 - "Integrative analysis of the molecular signature of target genes involved in the antitumor effects of cantharidin on hepatocellular carcinoma." 05/18/2023 - "Cantharidin suppresses hepatocellular carcinoma development by regulating EZH2/H3K27me3-dependent cell cycle progression and antitumour immune response." 01/01/2022 - "Cantharidin can inhibit the growth and promote apoptosis of hepatocellular carcinoma cells. "
5.	Pain (Aches) 08/01/2009 - "Topical cantharidin applications are used for the treatment of severe chronic lumbar pain in traditional European medicine (TEM). " 07/01/2009 - "Ninety-two percent of respondents reported satisfaction with cantharidin's efficacy, but 79% reported side effects, with discomfort/pain and blistering being the most common. " 04/01/2006 - "The case and the potential of topical cantharidin in pain syndromes are discussed." 04/01/2006 - "The multimodal CAM treatment resulted in a rapid clinical and x-ray resolution of pneumonia, and cantharidin treatment effectively relieved pain. " 08/01/2009 - "In this first study on the efficacy of cantharidin blisters, a clinically relevant pain-relieving short-term effect on LSS was observed. "

Related Drugs and Biologics

1.	Salicylic Acid (2 Hydroxybenzoic Acid)
2.	VP-102
3.	Solutions
4.	Podophyllotoxin (Condylox)
5.	Cisplatin (Platino)
6.	norcantharidin
7.	Liposomes (Liposome)
8.	Irritants (Vesicants)
9.	Nitrogen
10.	Therapeutic Uses

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Cryotherapy (Therapy, Cold)
4.	Radiotherapy
5.	Ambulatory Care (Outpatient Care)