Cannabinoids

Compounds having the cannabinoid structure. They were originally extracted from Cannabis sativa L. The most pharmacologically active constituents are TETRAHYDROCANNABINOL; CANNABINOL; and CANNABIDIOL.

Also Known As:

Networked: 5901 relevant articles (494 outcomes, 1154 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Di Marzo, Vincenzo: 58 articles (01/2021 - 03/2002)
2.	Fernández-Ruiz, Javier: 48 articles (12/2021 - 04/2002)
3.	Mechoulam, Raphael: 42 articles (01/2022 - 02/2002)
4.	Guzmán, Manuel: 41 articles (01/2023 - 04/2002)
5.	Makriyannis, Alexandros: 39 articles (10/2022 - 09/2001)
6.	Lichtman, Aron H: 31 articles (10/2022 - 08/2002)
7.	Mackie, Ken: 30 articles (10/2021 - 08/2003)
8.	Parker, Linda A: 29 articles (11/2021 - 04/2002)
9.	Hohmann, Andrea G: 28 articles (10/2021 - 12/2002)
10.	Bifulco, Maurizio: 27 articles (03/2022 - 03/2002)

Related Diseases

1.	Pain (Aches) 01/09/2020 - "In conclusion, synthetic cannabinoids are one of the most promising classes of drugs in pain medicine, and preclinical research should focus on identifying new and improved alternatives for a better clinical and preclinical outcome." 02/01/2016 - "The 13 studies with parallel or cross-over design yielded the following results with 95 % confidence intervals (CI): cannabinoids were superior to placebo in the reduction of mean pain intensity with SMD - 0.10 (95 % CI - 0.20- - 0.00, p = 0.05, 13 studies with 1565 participants), in the frequency of at least a 30 % reduction in pain with an RD of 0.10 [95 % CI 0.03-0.16, p = 0.004, 9 studies with 1346 participants, number needed to treat for additional benefit (NNTB) 14, 95 % CI 8-45] and in the frequency of a large or very large global improvement with an RD of 0.09 (95 % CI 0.01-0.17, p = 0.009, 7 studies with 1092 participants). " 01/01/2023 - "While pain tolerance was significantly improved in animals treated with D8-THC (3.2 and 10 mg/kg-bw/day, day 14), results across minor cannabinoids were inconsistent and warrant further study. " 01/01/2023 - "Meta-analysis of data from eight studies showed a significant reduction in daily pain scores in the cannabinoid (CB) group (SMD: -0.55, 95% CI:-0.69 to -0.19, 95% PI: -1.51 to 0.39, p=0.003, I2=82.49, τ2=0.20, Q-statistic=47.69, GRADE: moderate certainty). " 12/01/2021 - "Modulation of the endo-cannabinoid system has demonstrated significant improvement in both pain and locomotor function in pre-clinical SCI models; however, the risk of bias is unclear in all studies. "
2.	Neoplasms (Cancer) 12/01/2023 - "These findings can help to determine how cannabinoids can be used most effectively to improve the efficacy of cancer treatment." 08/01/2019 - "However, there is very little evidence on safety or efficacy of cannabinoids in children being treated with cancer. " 01/01/2017 - "Results and analysis suggest that INH route may offer more promise for targeting tumor cells with radiosensitizers and cannabinoids from the perspective of maximizing damage to lung tumors cells while minimizing any collateral damage or side effects." 06/01/2004 - "In cancer patients, cannabinoids proved more effective than placebo but less than gestagenes. " 01/01/2019 - "Our analysis showed cannabinoid is effective in increasing appetite in cancer patients. "
3.	Multiple Sclerosis 12/15/2006 - "Many reports have shown that cannabinoids might be beneficial in the symptomatic treatment of multiple sclerosis (MS). " 09/01/2001 - "Data, initially anecdotal, but recently supported on more solid experimental evidence, suggest that cannabinoids might be beneficial in the treatment of some of the symptoms of multiple sclerosis (MS). " 01/01/2023 - "Are Cannabis and Cannabinoids Effective for Symptomatic Treatment in People With Multiple Sclerosis?: A Cochrane Review Summary With Commentary." 12/01/2022 - "Cannabinoids proved to be effective in spasticity in multiple sclerosis, but evidence in other types of spasticity is lacking. " 03/10/2017 - "Are cannabinoids effective in multiple sclerosis?"
4.	Neuralgia (Stump Neuralgia) 04/01/2004 - "Although cannabinoids have anti-hyperalgesic effects in animal models of nerve injury, there are currently very few prospective trials of the efficacy of cannabinoids in neuropathic pain in humans. " 01/01/2024 - "Cannabinoid treatment has been reported to be beneficial for several disease conditions including neuropathic pain. " 01/01/2022 - "Add-on treatment with cannabinoids is effective for treatment of severe neuropathic pain with inadequate response to established treatments. " 01/01/2008 - "The development of cannabinoid drugs to target neuropathic pain with improved therapeutic ratios will depend upon the development of cannabinoid treatments with reduced psychoactivity." 04/01/2004 - "Are oral cannabinoids safe and effective in refractory neuropathic pain?"
5.	Chronic Pain 01/01/2020 - "Results from systematic reviews have demonstrated a statistically significant reduction in chronic pain conditions with cannabinoids, compared with placebo, although the effects might be considered small and did not reach the minimally important difference. " 11/15/2017 - "Although exogenous agonists for cannabinoid (CB) receptors are clinically effective for treating chronic pain, global activation of brain CB receptors causes frequent central nervous system (CNS) side-effects. " 01/01/2021 - "Current evidence suggests that cannabinoids are safe with minimal side effects and are effective in managing chronic pain. " 01/01/2021 - "The efficacy of cannabinoids for the treatment of chronic pain is not well established. " 01/01/2023 - "Meta-analyses and Trial Sequential Analysis showed that cannabinoids reduced chronic pain (mean difference NRS -0.43; 98% CI -0.72 to -0.15; P = 0.0004) and improved quality of sleep (mean difference -0.42; 95% CI -0.65 to -0.20; P = 0.0003). "

Related Drugs and Biologics

1.	Cannabidiol
2.	Cannabinoids
3.	Dronabinol (THC)
4.	Analgesics (Analgesic Drugs)
5.	CB1 Cannabinoid Receptor (CB1 Receptor)
6.	Opioid Analgesics (Opioids)
7.	Medical Marijuana
8.	nabilone (Cesamet)
9.	Endocannabinoids
10.	Ligands

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Pain Management
4.	Oral Administration
5.	Analgesia