Canavanine

05/01/1996 - "3. In conclusion, L-canavanine produced beneficial haemodynamic and metabolic effects and improved survival in rodent endotoxic shock. "
02/01/1999 - "In conclusion, in a rodent model of endotoxinic shock, the continuous infusion of L-canavanine, a selective iNOS inhibitor, improved the systemic hemodynamic parameters and the intracellular bio-energetic patterns estimated by in vivo 31P MRS. "
12/12/1994 - "L-canavanine restores blood pressure in a rat model of endotoxic shock."
03/01/2001 - "This study suggests that L-canavanine induces tissue hypoperfusion and ischemia with concomitant hypersecretion of ET-1 in dogs with endotoxic shock."
03/01/1997 - "To investigate the hemodynamic effects of L-canavanine (an inhibitor of inducible, but not of constitutive, nitric oxide synthase) in endotoxic shock. "

01/01/1995 - "Such hypothesis is confirmed by our in vivo experiments, showing that the administration of the NOS inhibitor L-canavanine to endothelioma-bearing mice significantly reduced both the volume and the relapse time of the tumor."
06/01/1986 - "The reduction in tumor volume, expressed as the percentage of regression, was 22% in animals receiving canavanine, 3.0 g/kg daily for 5 days and 60% in the 3.0-g/kg-daily-for-9-days treatment group. "
06/01/1986 - "When the tumors reached a size of 500 to 1000 mm3, the rats received canavanine, 2.0 g/kg or 3.0 g/kg s.c. "
06/01/1986 - "Growth inhibition of a rat colon tumor by L-canavanine."
09/01/1983 - "Enhancement of human tumor cell killing by L-canavanine in combination with gamma-radiation."

11/01/1972 - "The effects of canavanine and of arginine starvation on macromolecular synthesis in Chlamydomonas reinhardi."
02/01/2011 - "Our data suggest that the incorporation of canavanine into anticancer treatment schemes based on artificially created arginine starvation could be a novel strategy in tumor enzymochemotherapy."
03/01/2016 - "It was previously demonstrated in in vitro experiments that canavanine (Cav), a natural toxic arginine analogue of plant origin, is a promising candidate for augmenting the antineoplastic effects of arginine starvation. "
07/01/1976 - "The rates and extents of protein degradation during starvation for a carbon source or during growth after exposure to the amino acid analogue canavanine do not seem to be affected by apeA mutations. "
05/01/2012 - "In this report, we evaluated, for the first time, the efficacy of arginine deprivation as anticancer therapy in three-dimensional (3D) cultures of human tumor cells, and propose a new combinatorial metabolic-chemo-radio-treatment regime based on arginine starvation, low doses of arginine natural analog canavanine and irradiation. "

03/01/1997 - "L-canavanine significantly increased urine output and reduced the severity of lactic acidosis. "
03/01/2001 - "The LPS-induced lactic acidosis and hypersecretion of ET-1 were aggravated after L-canavanine infusion. "
05/01/1996 - "In contrast to L-canavanine, nitro-L-arginine methyl ester increased blood pressure at the expense of a severe fall in cardiac index, while largely enhancing lactic acidosis. "

05/01/1997 - "In the present study, we evaluated the effects of L-canavanine, a selective iNOS inhibitor, in an animal model of septic shock, with a particular focus on tissue oxidative metabolism and organ functions. "
01/11/1996 - "L-Canavanine is a potential agent in the treatment of endotoxin shock."
05/01/1996 - "The aim of this study was to evaluate the effects of L-canavanine, a potentially selective inhibitor of inducible nitric oxide synthase, in an animal model of septic shock. "
08/15/2003 - "Comparative effects of dexamethasone and L-canavanine in experimental septic shock."
02/01/2002 - "Effect of L-canavanine, an Inhibitor of inducible nitric oxide synthase, on myocardial dysfunction during septic shock."