Camptothecin

An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.

Also Known As:

Networked: 1416 relevant articles (77 outcomes, 234 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Pommier, Yves: 32 articles (09/2015 - 02/2002)
2.	Pisano, Claudio: 11 articles (01/2013 - 12/2002)
3.	Zunino, Franco: 11 articles (07/2012 - 12/2002)
4.	De Cesare, Michelandrea: 8 articles (07/2012 - 12/2002)
5.	Coy, David H: 8 articles (09/2007 - 03/2003)
6.	Sinko, Patrick J: 7 articles (01/2014 - 08/2002)
7.	Davis, Mark E: 7 articles (08/2013 - 05/2004)
8.	Bucci, Federica: 7 articles (12/2012 - 04/2003)
9.	Antony, Smitha: 7 articles (01/2010 - 12/2003)
10.	Pommier, Y: 7 articles (05/2006 - 02/2000)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2002 - "Camptothecin is a potent antineoplastic agent that has shown efficacy against multiple tumor lines in vitro; unfortunately, systemic toxicity has limited its in vivo efficacy. " 11/22/2001 - "Such conjugates have been optimized for enhanced solubility, stabilization of the camptothecin lactone ring, sufficient hydrolytic and proteolytic stability, and for an overall improvement in tumor selectivity. " 01/01/2000 - "Camptothecin (CPT) class of compounds has been demonstrated to be effective against a broad spectrum of tumors. " 04/01/2009 - "A novel camptothecin derivative incorporated in nano-carrier induced distinguished improvement in solubility, stability and anti-tumor activity both in vitro and in vivo." 10/28/2015 - "These NPs showed improved tumor target ability and enhanced aggregation of camptothecin (CPT) in tumor site and prominent suppression of tumor growth. "
2.	Carcinoma (Carcinomatosis) 06/28/2010 - "Following treatment with the camptothecin or ionizing radiation, both inducing double-strand DNA breaks, the ovarian carcinoma A2780 cells exhibited activation of the ATM-Chk2 pathway and early induction of apoptosis. " 08/01/2007 - "After a short dose of camptothecin in human colon carcinoma HT29 cells, DNA replication was inhibited rapidly and did not recover for several hours following drug removal. " 05/11/2006 - "In human colon carcinoma HCT116 cells with wild-type (wt) p53, gammaH2AX reverses after camptothecin removal. " 10/01/2004 - "Cytotoxic effect of different camptothecin formulations on human colon carcinoma in vitro." 11/03/2003 - "Using an isogenic cell system, we demonstrate that c-Myc overexpression in colon carcinoma LoVo cells resulted in sensitisation to camptothecin-induced apoptosis, thus identifying c-Myc as a potential marker predicting response of colorectal tumour cells to camptothecin. "
3.	Breast Neoplasms (Breast Cancer) 01/01/2010 - "A novel camptothecin analog that is effective against breast cancer resistance protein (BCRP)-positive cells was screened, and a water soluble prodrug was generated. " 04/01/2006 - "The purpose of this phase II study was to evaluate the efficacy and tolerability of Orathecin, an oral camptothecin analog that has exhibited antitumor activity in breast cancer patients during preclinical studies. " 01/01/2006 - "Present study is focused on the role of Bid in the control of Bax-GFP and Smac/DIABLO-GFP kinetics in breast cancer MCF-7 cells stimulated to apoptosis with camptothecin (CPT). " 04/01/2015 - "Breast cancer cells grown under hypoxic conditions were treated with the dual topoisomerase-1 (TOPO-1) and HIF-1α inhibitor camptothecin and assessed for their CSC content. " 04/01/2015 - "CRLX101, an investigational camptothecin-containing nanoparticle-drug conjugate, targets cancer stem cells and impedes resistance to antiangiogenic therapy in mouse models of breast cancer."
4.	Colonic Neoplasms (Colon Cancer) 11/01/2013 - "To evaluate the impact of camptothecin (CPT) on MAPKs in human colon cancer, we studied HCT116 and CaCo2 colon cancer cells. " 09/01/2013 - "We previously described the camptothecin-resistant colon cancer cell line DLDSNR6, which has a Gly365Ser missense mutation in Top1. " 03/01/2012 - "Soluplus--solubilized citrated camptothecin--a potential drug delivery strategy in colon cancer." 10/01/2011 - "Camptothecin (CPT), the derivatives of which are used clinically for the treatment of metastatic colon cancer, is isolated from intact plants that can be subjected to environmental fluctuations. " 11/25/2008 - "Anti-proliferative and pro-apoptotic effect of CPT13, a novel camptothecin analog, on human colon cancer HCT8 cell line."
5.	Melanoma (Melanoma, Malignant) 01/01/2011 - "Because of the challenges in treating melanoma and S-phase specificity of camptothecin, we performed a study to search what melanoma cell cycle phases are susceptible to this substance. " 07/15/1992 - "The plant alkaloid camptothecin and three camptothecin derivatives were used to study responses of human malignant melanoma (BRO) cells xenografted in immunodeficient (nude) mice. " 08/01/2013 - "The camptothecin accumulation in melanomas increased by 6.4-fold after incorporation into C-QDNLCs. " 08/01/2013 - "Cytotoxicity of the nanoparticles against melanoma cells was superior to that of free camptothecin. " 11/01/2011 - "Camptothecin induces p53-dependent and -independent apoptogenic signaling in melanoma cells."

Related Drugs and Biologics

1.	Type I DNA Topoisomerases (Topoisomerase I)
2.	irinotecan (Camptosar)
3.	Cisplatin (Platino)
4.	Polymers
5.	Topotecan (Hycamtin)
6.	Doxorubicin (Adriamycin)
7.	DNA (Deoxyribonucleic Acid)
8.	Topoisomerase I Inhibitors
9.	Paclitaxel (Taxol)
10.	belotecan

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Drug Therapy (Chemotherapy)
3.	Microspheres (Microsphere)
4.	Aftercare (After-Treatment)
5.	Therapeutics